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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6K7Y

Intact human mitochondrial calcium uniporter complex with MICU1/MICU2 subunits

Functional Information from GO Data
ChainGOidnamespacecontents
A0051560biological_processmitochondrial calcium ion homeostasis
B0051560biological_processmitochondrial calcium ion homeostasis
C0051560biological_processmitochondrial calcium ion homeostasis
D0051560biological_processmitochondrial calcium ion homeostasis
E0036444biological_processcalcium import into the mitochondrion
E0051560biological_processmitochondrial calcium ion homeostasis
E1990246cellular_componentuniplex complex
F0036444biological_processcalcium import into the mitochondrion
F0051560biological_processmitochondrial calcium ion homeostasis
F1990246cellular_componentuniplex complex
G0036444biological_processcalcium import into the mitochondrion
G0051560biological_processmitochondrial calcium ion homeostasis
G1990246cellular_componentuniplex complex
H0036444biological_processcalcium import into the mitochondrion
H0051560biological_processmitochondrial calcium ion homeostasis
H1990246cellular_componentuniplex complex
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005739cellular_componentmitochondrion
I0005743cellular_componentmitochondrial inner membrane
I0005758cellular_componentmitochondrial intermembrane space
I0006811biological_processmonoatomic ion transport
I0006816biological_processcalcium ion transport
I0006851biological_processmitochondrial calcium ion transmembrane transport
I0006952biological_processdefense response
I0019855molecular_functioncalcium channel inhibitor activity
I0031966cellular_componentmitochondrial membrane
I0034704cellular_componentcalcium channel complex
I0036444biological_processcalcium import into the mitochondrion
I0042802molecular_functionidentical protein binding
I0044284cellular_componentmitochondrial crista junction
I0046872molecular_functionmetal ion binding
I0046982molecular_functionprotein heterodimerization activity
I0051260biological_processprotein homooligomerization
I0051560biological_processmitochondrial calcium ion homeostasis
I0051561biological_processpositive regulation of mitochondrial calcium ion concentration
I0061891molecular_functioncalcium ion sensor activity
I0070509biological_processcalcium ion import
I0071277biological_processcellular response to calcium ion
I0072732biological_processcellular response to calcium ion starvation
I1900069biological_processregulation of cellular hyperosmotic salinity response
I1903852biological_processpositive regulation of cristae formation
I1990246cellular_componentuniplex complex
J0005509molecular_functioncalcium ion binding
J0006851biological_processmitochondrial calcium ion transmembrane transport
N0051560biological_processmitochondrial calcium ion homeostasis
O0051560biological_processmitochondrial calcium ion homeostasis
P0051560biological_processmitochondrial calcium ion homeostasis
Q0051560biological_processmitochondrial calcium ion homeostasis
R0036444biological_processcalcium import into the mitochondrion
R0051560biological_processmitochondrial calcium ion homeostasis
R1990246cellular_componentuniplex complex
S0036444biological_processcalcium import into the mitochondrion
S0051560biological_processmitochondrial calcium ion homeostasis
S1990246cellular_componentuniplex complex
T0036444biological_processcalcium import into the mitochondrion
T0051560biological_processmitochondrial calcium ion homeostasis
T1990246cellular_componentuniplex complex
U0036444biological_processcalcium import into the mitochondrion
U0051560biological_processmitochondrial calcium ion homeostasis
U1990246cellular_componentuniplex complex
V0005509molecular_functioncalcium ion binding
V0005515molecular_functionprotein binding
V0005739cellular_componentmitochondrion
V0005743cellular_componentmitochondrial inner membrane
V0005758cellular_componentmitochondrial intermembrane space
V0006811biological_processmonoatomic ion transport
V0006816biological_processcalcium ion transport
V0006851biological_processmitochondrial calcium ion transmembrane transport
V0006952biological_processdefense response
V0019855molecular_functioncalcium channel inhibitor activity
V0031966cellular_componentmitochondrial membrane
V0034704cellular_componentcalcium channel complex
V0036444biological_processcalcium import into the mitochondrion
V0042802molecular_functionidentical protein binding
V0044284cellular_componentmitochondrial crista junction
V0046872molecular_functionmetal ion binding
V0046982molecular_functionprotein heterodimerization activity
V0051260biological_processprotein homooligomerization
V0051560biological_processmitochondrial calcium ion homeostasis
V0051561biological_processpositive regulation of mitochondrial calcium ion concentration
V0061891molecular_functioncalcium ion sensor activity
V0070509biological_processcalcium ion import
V0071277biological_processcellular response to calcium ion
V0072732biological_processcellular response to calcium ion starvation
V1900069biological_processregulation of cellular hyperosmotic salinity response
V1903852biological_processpositive regulation of cristae formation
V1990246cellular_componentuniplex complex
W0005509molecular_functioncalcium ion binding
W0006851biological_processmitochondrial calcium ion transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLNGDGEVDmeEF
ChainResidueDetails
IASP231-PHE243
IASP421-PHE433
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues488
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32862359","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues48
DetailsTopological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues720
DetailsRegion: {"description":"N-terminal MCU domain","evidences":[{"source":"PubMed","id":"26341627","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues40
DetailsRegion: {"description":"Juxtamembrane helix","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33296646","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues472
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues64
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32862359","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine; by CaMK2","evidences":[{"source":"PubMed","id":"23051746","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsModified residue: {"description":"S-glutathionyl cysteine","evidences":[{"source":"PubMed","id":"28262504","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3UMR5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues88
DetailsTopological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27642048","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues32
DetailsMotif: {"description":"GXXXX[G/A/S]","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues140
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues70
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues6
DetailsRegion: {"description":"K/R-ring","evidences":[{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues20
DetailsRegion: {"description":"C-helix region","evidences":[{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VCX5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"Asymmetric dimethylarginine","evidences":[{"source":"PubMed","id":"27642082","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues70
DetailsDomain: {"description":"EF-hand 3; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues70
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

249697

PDB entries from 2026-02-25

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