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6K7G

Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1 state class1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0005215molecular_functiontransporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005802cellular_componenttrans-Golgi network
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0007612biological_processlearning
A0012505cellular_componentendomembrane system
A0015914biological_processphospholipid transport
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
A0030335biological_processpositive regulation of cell migration
A0030672cellular_componentsynaptic vesicle membrane
A0031090cellular_componentorganelle membrane
A0031410cellular_componentcytoplasmic vesicle
A0034220biological_processmonoatomic ion transmembrane transport
A0035577cellular_componentazurophil granule membrane
A0035579cellular_componentspecific granule membrane
A0042584cellular_componentchromaffin granule membrane
A0043231cellular_componentintracellular membrane-bounded organelle
A0045202cellular_componentsynapse
A0045332biological_processphospholipid translocation
A0046872molecular_functionmetal ion binding
A0061092biological_processpositive regulation of phospholipid translocation
A0070062cellular_componentextracellular exosome
A0090556molecular_functionphosphatidylserine floppase activity
A0098655biological_processmonoatomic cation transmembrane transport
A0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
A0140331biological_processaminophospholipid translocation
A0140346molecular_functionphosphatidylserine flippase activity
A0150104biological_processtransport across blood-brain barrier
A1990531cellular_componentphospholipid-translocating ATPase complex
C0005198molecular_functionstructural molecule activity
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005886cellular_componentplasma membrane
C0006855biological_processxenobiotic transmembrane transport
C0006869biological_processlipid transport
C0010976biological_processpositive regulation of neuron projection development
C0015247molecular_functionaminophospholipid flippase activity
C0015917biological_processaminophospholipid transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0030658cellular_componenttransport vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0031901cellular_componentearly endosome membrane
C0031902cellular_componentlate endosome membrane
C0035577cellular_componentazurophil granule membrane
C0035579cellular_componentspecific granule membrane
C0036010biological_processprotein localization to endosome
C0045332biological_processphospholipid translocation
C0061092biological_processpositive regulation of phospholipid translocation
C0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
C0140331biological_processaminophospholipid translocation
C1990531cellular_componentphospholipid-translocating ATPase complex
Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
AASP409-THR415

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues862
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-LEU65
AGLU116-GLN297
ALYS367-ILE857
ALEU911-LEU940
AILE1000-VAL1005

site_idSWS_FT_FI2
Number of Residues211
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
APRO66-LEU86
AVAL1045-GLN1070
AVAL93-LYS115
AILE298-TRP319
ALEU345-VAL366
AGLU858-ILE878
ALEU891-GLU910
APHE941-TYR962
AVAL977-SER999
APHE1006-GLU1026

site_idSWS_FT_FI3
Number of Residues70
DetailsTOPO_DOM: Exoplasmic loop => ECO:0000255
ChainResidueDetails
ALEU87-ASP92
AASN320-PHE344
AGLY879-PRO890
ALEU963-THR976
AALA1027-PRO1044

site_idSWS_FT_FI4
Number of Residues1
DetailsACT_SITE: 4-aspartylphosphate intermediate => ECO:0000269|PubMed:31416931
ChainResidueDetails
AASP409

site_idSWS_FT_FI5
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:31416931
ChainResidueDetails
AASP409
ALYS410
ATHR411
ASER549
AVAL801
ASER804

site_idSWS_FT_FI6
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04191
ChainResidueDetails
ATHR508
ALYS572
AGLN605
ALYS685
ALEU686
ALEU687
ALYS775
ATHR781

site_idSWS_FT_FI7
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
AGLY741
ALEU1095

site_idSWS_FT_FI8
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q8NB49
ChainResidueDetails
AGLY805

site_idSWS_FT_FI9
Number of Residues1
DetailsSITE: Involved in the recognition of the lipid substrate on the exoplasmic side => ECO:0000250|UniProtKB:C7EXK4
ChainResidueDetails
AASN352

site_idSWS_FT_FI10
Number of Residues1
DetailsSITE: Involved in the release of the transported lipid into the cytosolic leaflet => ECO:0000250|UniProtKB:C7EXK4
ChainResidueDetails
AILE357

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18088087
ChainResidueDetails
ASER25

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P70704
ChainResidueDetails
ATHR28

site_idSWS_FT_FI13
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70704
ChainResidueDetails
ASER29
APHE443
AGLU1126

218853

PDB entries from 2024-04-24

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