6K63

The crystal structure of cytidine deaminase from Klebsiella pneumoniae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0042803	molecular_function	protein homodimerization activity
A	0046135	biological_process	pyrimidine nucleoside catabolic process
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0004126	molecular_function	cytidine deaminase activity
B	0005829	cellular_component	cytosol
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0042803	molecular_function	protein homodimerization activity
B	0046135	biological_process	pyrimidine nucleoside catabolic process
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0004126	molecular_function	cytidine deaminase activity
C	0005829	cellular_component	cytosol
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0042803	molecular_function	protein homodimerization activity
C	0046135	biological_process	pyrimidine nucleoside catabolic process
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0004126	molecular_function	cytidine deaminase activity
D	0005829	cellular_component	cytosol
D	0008270	molecular_function	zinc ion binding
D	0016787	molecular_function	hydrolase activity
D	0042803	molecular_function	protein homodimerization activity
D	0046135	biological_process	pyrimidine nucleoside catabolic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue DIO A 301

Chain	Residue
A	HIS182
A	ALA204
A	HIS208
A	PRO210

---

site_id	AC2
Number of Residues	4
Details	binding site for residue DIO A 302

Chain	Residue
A	TYR126
A	THR127
B	PHE165
B	DIO301

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 303

Chain	Residue
A	CYS129
A	CYS132
A	HOH610
A	HIS102

---

site_id	AC4
Number of Residues	5
Details	binding site for residue DIO B 301

Chain	Residue
A	PHE71
A	DIO302
B	ALA231
B	PHE233
B	HOH438

---

site_id	AC5
Number of Residues	4
Details	binding site for residue DIO B 302

Chain	Residue
B	HIS182
B	ALA204
B	HIS208
B	PRO210

---

site_id	AC6
Number of Residues	4
Details	binding site for residue DIO B 303

Chain	Residue
A	PHE165
B	TYR126
B	THR127
B	HOH542

---

site_id	AC7
Number of Residues	7
Details	binding site for residue DIO B 304

Chain	Residue
A	LEU170
A	ALA231
A	PHE233
B	SER69
B	PHE71
B	HOH404
B	HOH566

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 305

Chain	Residue
B	HIS102
B	CYS129
B	CYS132
B	HOH542

---

site_id	AC9
Number of Residues	4
Details	binding site for residue DIO C 301

Chain	Residue
C	HIS182
C	ALA204
C	HIS208
C	PRO210

---

site_id	AD1
Number of Residues	7
Details	binding site for residue DIO C 302

Chain	Residue
C	LEU170
C	ALA231
C	HOH420
C	HOH597
C	HOH599
D	SER69
D	PHE71

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN C 303

Chain	Residue
C	HIS102
C	CYS129
C	CYS132
C	HOH441

---

site_id	AD3
Number of Residues	4
Details	binding site for residue DIO D 301

Chain	Residue
C	TYR126
C	HOH441
D	PHE165
D	DIO302

---

site_id	AD4
Number of Residues	6
Details	binding site for residue DIO D 302

Chain	Residue
C	SER69
D	LEU170
D	ALA231
D	PHE233
D	DIO301
D	HOH652

---

site_id	AD5
Number of Residues	4
Details	binding site for residue DIO D 303

Chain	Residue
D	HIS182
D	ALA204
D	HIS208
D	PRO210

---

site_id	AD6
Number of Residues	4
Details	binding site for residue DIO D 304

Chain	Residue
C	PHE165
D	HIS102
D	TYR126
D	HOH439

---

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN D 305

Chain	Residue
D	HIS102
D	CYS129
D	CYS132
D	HOH439

---

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	35
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEqsAIshawlrgetslraitvnyt..............PCgh......CrqfM

Chain	Residue	Details
A	HIS102-MET136

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	480
Details	Domain: {"description":"CMP/dCMP-type deaminase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	432
Details	Domain: {"description":"CMP/dCMP-type deaminase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_01558","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01558","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---