Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6K4M

Cryo-EM structure of Holo-bacterioferritin form-II from Streptomyces coelicolor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008199	molecular_function	ferric iron binding
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
B	0004322	molecular_function	ferroxidase activity
B	0005506	molecular_function	iron ion binding
B	0005829	cellular_component	cytosol
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0008199	molecular_function	ferric iron binding
B	0016491	molecular_function	oxidoreductase activity
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
C	0004322	molecular_function	ferroxidase activity
C	0005506	molecular_function	iron ion binding
C	0005829	cellular_component	cytosol
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0008199	molecular_function	ferric iron binding
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
D	0004322	molecular_function	ferroxidase activity
D	0005506	molecular_function	iron ion binding
D	0005829	cellular_component	cytosol
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0008199	molecular_function	ferric iron binding
D	0016491	molecular_function	oxidoreductase activity
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
E	0004322	molecular_function	ferroxidase activity
E	0005506	molecular_function	iron ion binding
E	0005829	cellular_component	cytosol
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0008199	molecular_function	ferric iron binding
E	0016491	molecular_function	oxidoreductase activity
E	0020037	molecular_function	heme binding
E	0046872	molecular_function	metal ion binding
F	0004322	molecular_function	ferroxidase activity
F	0005506	molecular_function	iron ion binding
F	0005829	cellular_component	cytosol
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0008199	molecular_function	ferric iron binding
F	0016491	molecular_function	oxidoreductase activity
F	0020037	molecular_function	heme binding
F	0046872	molecular_function	metal ion binding
G	0004322	molecular_function	ferroxidase activity
G	0005506	molecular_function	iron ion binding
G	0005829	cellular_component	cytosol
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0008199	molecular_function	ferric iron binding
G	0016491	molecular_function	oxidoreductase activity
G	0020037	molecular_function	heme binding
G	0046872	molecular_function	metal ion binding
H	0004322	molecular_function	ferroxidase activity
H	0005506	molecular_function	iron ion binding
H	0005829	cellular_component	cytosol
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0008199	molecular_function	ferric iron binding
H	0016491	molecular_function	oxidoreductase activity
H	0020037	molecular_function	heme binding
H	0046872	molecular_function	metal ion binding
I	0004322	molecular_function	ferroxidase activity
I	0005506	molecular_function	iron ion binding
I	0005829	cellular_component	cytosol
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0008199	molecular_function	ferric iron binding
I	0016491	molecular_function	oxidoreductase activity
I	0020037	molecular_function	heme binding
I	0046872	molecular_function	metal ion binding
J	0004322	molecular_function	ferroxidase activity
J	0005506	molecular_function	iron ion binding
J	0005829	cellular_component	cytosol
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0008199	molecular_function	ferric iron binding
J	0016491	molecular_function	oxidoreductase activity
J	0020037	molecular_function	heme binding
J	0046872	molecular_function	metal ion binding
K	0004322	molecular_function	ferroxidase activity
K	0005506	molecular_function	iron ion binding
K	0005829	cellular_component	cytosol
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0008199	molecular_function	ferric iron binding
K	0016491	molecular_function	oxidoreductase activity
K	0020037	molecular_function	heme binding
K	0046872	molecular_function	metal ion binding
L	0004322	molecular_function	ferroxidase activity
L	0005506	molecular_function	iron ion binding
L	0005829	cellular_component	cytosol
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0008199	molecular_function	ferric iron binding
L	0016491	molecular_function	oxidoreductase activity
L	0020037	molecular_function	heme binding
L	0046872	molecular_function	metal ion binding
M	0004322	molecular_function	ferroxidase activity
M	0005506	molecular_function	iron ion binding
M	0005829	cellular_component	cytosol
M	0006826	biological_process	iron ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0008199	molecular_function	ferric iron binding
M	0016491	molecular_function	oxidoreductase activity
M	0020037	molecular_function	heme binding
M	0046872	molecular_function	metal ion binding
N	0004322	molecular_function	ferroxidase activity
N	0005506	molecular_function	iron ion binding
N	0005829	cellular_component	cytosol
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0008199	molecular_function	ferric iron binding
N	0016491	molecular_function	oxidoreductase activity
N	0020037	molecular_function	heme binding
N	0046872	molecular_function	metal ion binding
O	0004322	molecular_function	ferroxidase activity
O	0005506	molecular_function	iron ion binding
O	0005829	cellular_component	cytosol
O	0006826	biological_process	iron ion transport
O	0006879	biological_process	intracellular iron ion homeostasis
O	0008199	molecular_function	ferric iron binding
O	0016491	molecular_function	oxidoreductase activity
O	0020037	molecular_function	heme binding
O	0046872	molecular_function	metal ion binding
P	0004322	molecular_function	ferroxidase activity
P	0005506	molecular_function	iron ion binding
P	0005829	cellular_component	cytosol
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0008199	molecular_function	ferric iron binding
P	0016491	molecular_function	oxidoreductase activity
P	0020037	molecular_function	heme binding
P	0046872	molecular_function	metal ion binding
Q	0004322	molecular_function	ferroxidase activity
Q	0005506	molecular_function	iron ion binding
Q	0005829	cellular_component	cytosol
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0008199	molecular_function	ferric iron binding
Q	0016491	molecular_function	oxidoreductase activity
Q	0020037	molecular_function	heme binding
Q	0046872	molecular_function	metal ion binding
R	0004322	molecular_function	ferroxidase activity
R	0005506	molecular_function	iron ion binding
R	0005829	cellular_component	cytosol
R	0006826	biological_process	iron ion transport
R	0006879	biological_process	intracellular iron ion homeostasis
R	0008199	molecular_function	ferric iron binding
R	0016491	molecular_function	oxidoreductase activity
R	0020037	molecular_function	heme binding
R	0046872	molecular_function	metal ion binding
S	0004322	molecular_function	ferroxidase activity
S	0005506	molecular_function	iron ion binding
S	0005829	cellular_component	cytosol
S	0006826	biological_process	iron ion transport
S	0006879	biological_process	intracellular iron ion homeostasis
S	0008199	molecular_function	ferric iron binding
S	0016491	molecular_function	oxidoreductase activity
S	0020037	molecular_function	heme binding
S	0046872	molecular_function	metal ion binding
T	0004322	molecular_function	ferroxidase activity
T	0005506	molecular_function	iron ion binding
T	0005829	cellular_component	cytosol
T	0006826	biological_process	iron ion transport
T	0006879	biological_process	intracellular iron ion homeostasis
T	0008199	molecular_function	ferric iron binding
T	0016491	molecular_function	oxidoreductase activity
T	0020037	molecular_function	heme binding
T	0046872	molecular_function	metal ion binding
U	0004322	molecular_function	ferroxidase activity
U	0005506	molecular_function	iron ion binding
U	0005829	cellular_component	cytosol
U	0006826	biological_process	iron ion transport
U	0006879	biological_process	intracellular iron ion homeostasis
U	0008199	molecular_function	ferric iron binding
U	0016491	molecular_function	oxidoreductase activity
U	0020037	molecular_function	heme binding
U	0046872	molecular_function	metal ion binding
V	0004322	molecular_function	ferroxidase activity
V	0005506	molecular_function	iron ion binding
V	0005829	cellular_component	cytosol
V	0006826	biological_process	iron ion transport
V	0006879	biological_process	intracellular iron ion homeostasis
V	0008199	molecular_function	ferric iron binding
V	0016491	molecular_function	oxidoreductase activity
V	0020037	molecular_function	heme binding
V	0046872	molecular_function	metal ion binding
W	0004322	molecular_function	ferroxidase activity
W	0005506	molecular_function	iron ion binding
W	0005829	cellular_component	cytosol
W	0006826	biological_process	iron ion transport
W	0006879	biological_process	intracellular iron ion homeostasis
W	0008199	molecular_function	ferric iron binding
W	0016491	molecular_function	oxidoreductase activity
W	0020037	molecular_function	heme binding
W	0046872	molecular_function	metal ion binding
X	0004322	molecular_function	ferroxidase activity
X	0005506	molecular_function	iron ion binding
X	0005829	cellular_component	cytosol
X	0006826	biological_process	iron ion transport
X	0006879	biological_process	intracellular iron ion homeostasis
X	0008199	molecular_function	ferric iron binding
X	0016491	molecular_function	oxidoreductase activity
X	0020037	molecular_function	heme binding
X	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue FE2 A 201

Chain	Residue
A	GLU51
A	HIS54
A	ILE123
A	GLU127

site_id	AC2
Number of Residues	12
Details	binding site for residue HEM A 202

Chain	Residue
A	MET52
A	TYR71
B	ILE22
B	ASN23
B	ARG45
B	MET52
B	TYR71
A	LEU19
A	ILE22
A	ASN23
A	PHE26
A	PHE49

site_id	AC3
Number of Residues	4
Details	binding site for residue FE2 B 200

Chain	Residue
B	GLU51
B	HIS54
B	ILE123
B	GLU127

site_id	AC4
Number of Residues	4
Details	binding site for residue FE2 C 201

Chain	Residue
C	GLU51
C	HIS54
C	ILE123
C	GLU127

site_id	AC5
Number of Residues	8
Details	binding site for residue HEM C 202

Chain	Residue
C	PHE49
C	MET52
C	ARG53
C	HIS54
C	GLU56
D	ARG45
D	MET52
D	GLU56

site_id	AC6
Number of Residues	4
Details	binding site for residue FE2 D 201

Chain	Residue
D	GLU51
D	HIS54
D	ILE123
D	GLU127

site_id	AC7
Number of Residues	4
Details	binding site for residue FE2 F 201

Chain	Residue
F	GLU51
F	HIS54
F	ILE123
F	GLU127

site_id	AC8
Number of Residues	10
Details	binding site for residue HEM F 202

Chain	Residue
E	ILE22
E	ASN23
E	PHE26
E	MET52
E	GLU56
F	ASN23
F	PHE26
F	ARG45
F	PHE49
F	MET52

site_id	AC9
Number of Residues	4
Details	binding site for residue FE2 E 201

Chain	Residue
E	GLU51
E	HIS54
E	ILE123
E	GLU127

site_id	AD1
Number of Residues	4
Details	binding site for residue FE2 G 201

Chain	Residue
G	GLU51
G	HIS54
G	ILE123
G	GLU127

site_id	AD2
Number of Residues	4
Details	binding site for residue FE2 H 201

Chain	Residue
H	GLU51
H	HIS54
H	ILE123
H	GLU127

site_id	AD3
Number of Residues	10
Details	binding site for residue HEM H 202

Chain	Residue
H	ASN23
H	PHE26
H	MET52
H	ARG53
H	ALA55
H	GLU56
H	THR59
N	PHE26
N	PHE49
N	MET52

site_id	AD4
Number of Residues	3
Details	binding site for residue FE2 I 201

Chain	Residue
I	GLU18
I	GLU51
I	HIS54

site_id	AD5
Number of Residues	3
Details	binding site for residue FE2 J 201

Chain	Residue
J	GLU51
J	HIS54
J	GLU127

site_id	AD6
Number of Residues	8
Details	binding site for residue HEM K 301

Chain	Residue
J	MET52
J	GLU56
K	ILE22
K	ASN23
K	PHE26
K	PHE49
K	MET52
K	GLU56

site_id	AD7
Number of Residues	4
Details	binding site for residue FE2 K 302

Chain	Residue
K	GLU18
K	GLU51
K	HIS54
K	ILE123

site_id	AD8
Number of Residues	5
Details	binding site for residue FE2 L 201

Chain	Residue
L	GLU51
L	HIS54
L	ILE123
L	ASP126
L	GLU127

site_id	AD9
Number of Residues	8
Details	binding site for residue HEM L 202

Chain	Residue
L	TYR71
M	PHE26
M	MET52
M	GLU56
L	PHE26
L	PHE49
L	MET52
L	ARG53

site_id	AE1
Number of Residues	4
Details	binding site for residue FE2 M 201

Chain	Residue
M	GLU51
M	HIS54
M	ILE123
M	GLU127

site_id	AE2
Number of Residues	4
Details	binding site for residue FE2 N 200

Chain	Residue
N	GLU51
N	HIS54
N	ILE123
N	GLU127

site_id	AE3
Number of Residues	4
Details	binding site for residue FE2 O 201

Chain	Residue
O	GLU51
O	HIS54
O	ILE123
O	GLU127

site_id	AE4
Number of Residues	4
Details	binding site for residue FE2 P 201

Chain	Residue
P	GLU51
P	HIS54
P	ILE123
P	GLU127

site_id	AE5
Number of Residues	12
Details	binding site for residue HEM P 202

Chain	Residue
O	ILE22
O	ASN23
O	PHE26
O	PHE49
O	MET52
O	TYR71
P	LEU19
P	ILE22
P	ASN23
P	MET52
P	GLU56
P	TYR71

site_id	AE6
Number of Residues	3
Details	binding site for residue FE2 Q 201

Chain	Residue
Q	ASP126
Q	GLU127
Q	HIS130

site_id	AE7
Number of Residues	10
Details	binding site for residue HEM R 301

Chain	Residue
Q	ILE22
Q	ASN23
Q	PHE49
Q	MET52
Q	GLU56
Q	TYR71
R	ASN23
R	PHE26
R	ARG45
R	MET52

site_id	AE8
Number of Residues	4
Details	binding site for residue FE2 R 302

Chain	Residue
R	GLU51
R	HIS54
R	ILE123
R	GLU127

site_id	AE9
Number of Residues	4
Details	binding site for residue FE2 S 201

Chain	Residue
S	GLU51
S	HIS54
S	ILE123
S	GLU127

site_id	AF1
Number of Residues	10
Details	binding site for residue HEM S 202

Chain	Residue
I	ILE22
I	ASN23
I	PHE26
I	MET52
I	TYR71
S	ASN23
S	PHE26
S	ARG45
S	PHE49
S	MET52

site_id	AF2
Number of Residues	4
Details	binding site for residue FE2 T 201

Chain	Residue
T	GLU51
T	HIS54
T	ILE123
T	GLU127

site_id	AF3
Number of Residues	4
Details	binding site for residue FE2 U 201

Chain	Residue
U	GLU51
U	HIS54
U	ILE123
U	GLU127

site_id	AF4
Number of Residues	7
Details	binding site for residue HEM U 202

Chain	Residue
T	MET52
T	TYR71
U	LEU19
U	ILE22
U	ASN23
U	PHE26
U	MET52

site_id	AF5
Number of Residues	3
Details	binding site for residue FE2 V 201

Chain	Residue
V	GLU18
V	GLU51
V	HIS54

site_id	AF6
Number of Residues	3
Details	binding site for residue FE2 W 201

Chain	Residue
W	GLU51
W	HIS54
W	GLU127

site_id	AF7
Number of Residues	10
Details	binding site for residue HEM W 202

Chain	Residue
V	ILE22
V	ASN23
V	PHE26
V	MET52
V	TYR71
W	ASN23
W	PHE26
W	ARG45
W	PHE49
W	MET52

site_id	AF8
Number of Residues	8
Details	binding site for residue HEM X 301

Chain	Residue
G	ILE22
G	ASN23
G	PHE26
G	MET52
X	ILE22
X	ASN23
X	PHE49
X	MET52

site_id	AF9
Number of Residues	5
Details	binding site for residue FE2 X 302

Chain	Residue
X	GLU18
X	GLU51
X	HIS54
X	ILE123
X	GLU127

Functional Information from PROSITE/UniProt

site_id	PS00549
Number of Residues	19
Details	BACTERIOFERRITIN Bacterioferritin signature. MqGdpeVIefLneqLtaeL

Chain	Residue	Details
A	MET1-LEU19

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3456
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	144
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)