6K3L
Crystal structure of CX-4945 bound Cka1 from C. neoformans
Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005634 | cellular_component | nucleus |
B | 0005829 | cellular_component | cytosol |
B | 0005956 | cellular_component | protein kinase CK2 complex |
B | 0006356 | biological_process | regulation of transcription by RNA polymerase I |
B | 0006359 | biological_process | regulation of transcription by RNA polymerase III |
B | 0006468 | biological_process | protein phosphorylation |
B | 0006974 | biological_process | DNA damage response |
B | 0016310 | biological_process | phosphorylation |
B | 0018105 | biological_process | peptidyl-serine phosphorylation |
B | 0018107 | biological_process | peptidyl-threonine phosphorylation |
B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
B | 0046872 | molecular_function | metal ion binding |
B | 0051726 | biological_process | regulation of cell cycle |
B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | binding site for residue 3NG B 401 |
Chain | Residue |
B | GLY45 |
B | ILE173 |
B | ASP174 |
B | HOH529 |
B | HOH533 |
B | ARG46 |
B | GLY47 |
B | ILE65 |
B | LYS67 |
B | THR112 |
B | TYR114 |
B | VAL115 |
B | MET162 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue SO4 B 402 |
Chain | Residue |
B | LYS76 |
B | ARG79 |
B | ARG154 |
B | ASN188 |
B | HOH527 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGKYSEVFeSihlptdsk..........CIVK |
Chain | Residue | Details |
B | VAL44-LYS67 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
Chain | Residue | Details |
B | ILE151-ILE163 |