6K1L

E53A mutant of a putative cystathionine gamma-lyase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003962	molecular_function	cystathionine gamma-synthase activity
A	0004123	molecular_function	cystathionine gamma-lyase activity
A	0005737	cellular_component	cytoplasm
A	0016829	molecular_function	lyase activity
A	0019343	biological_process	cysteine biosynthetic process via cystathionine
A	0019346	biological_process	transsulfuration
A	0030170	molecular_function	pyridoxal phosphate binding
A	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
A	0080146	molecular_function	L-cysteine desulfhydrase activity
B	0003962	molecular_function	cystathionine gamma-synthase activity
B	0004123	molecular_function	cystathionine gamma-lyase activity
B	0005737	cellular_component	cytoplasm
B	0016829	molecular_function	lyase activity
B	0019343	biological_process	cysteine biosynthetic process via cystathionine
B	0019346	biological_process	transsulfuration
B	0030170	molecular_function	pyridoxal phosphate binding
B	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
B	0080146	molecular_function	L-cysteine desulfhydrase activity
C	0003962	molecular_function	cystathionine gamma-synthase activity
C	0004123	molecular_function	cystathionine gamma-lyase activity
C	0005737	cellular_component	cytoplasm
C	0016829	molecular_function	lyase activity
C	0019343	biological_process	cysteine biosynthetic process via cystathionine
C	0019346	biological_process	transsulfuration
C	0030170	molecular_function	pyridoxal phosphate binding
C	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
C	0080146	molecular_function	L-cysteine desulfhydrase activity
D	0003962	molecular_function	cystathionine gamma-synthase activity
D	0004123	molecular_function	cystathionine gamma-lyase activity
D	0005737	cellular_component	cytoplasm
D	0016829	molecular_function	lyase activity
D	0019343	biological_process	cysteine biosynthetic process via cystathionine
D	0019346	biological_process	transsulfuration
D	0030170	molecular_function	pyridoxal phosphate binding
D	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
D	0080146	molecular_function	L-cysteine desulfhydrase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue PLP A 600

Chain	Residue
A	SER83
B	TYR54
B	ARG56
A	GLY84
A	MET85
A	TYR108
A	ASP181
A	SER203
A	THR205
A	LYS206
A	GLY216

---

site_id	AC2
Number of Residues	11
Details	binding site for residue PLP B 401

Chain	Residue
A	TYR54
A	ARG56
B	SER83
B	GLY84
B	MET85
B	TYR108
B	ASP181
B	SER203
B	THR205
B	LYS206
B	PYR402

---

site_id	AC3
Number of Residues	8
Details	binding site for residue PYR B 402

Chain	Residue
B	TYR108
B	ASN156
B	LYS206
B	GLU334
B	SER335
B	THR350
B	ARG370
B	PLP401

---

site_id	AC4
Number of Residues	12
Details	binding site for residue PLP C 401

Chain	Residue
C	SER83
C	GLY84
C	MET85
C	TYR108
C	GLU152
C	ASP181
C	SER203
C	THR205
C	LYS206
C	PYR402
D	TYR54
D	ARG56

---

site_id	AC5
Number of Residues	9
Details	binding site for residue PYR C 402

Chain	Residue
C	TYR108
C	ASN156
C	LYS206
C	GLU334
C	SER335
C	LEU336
C	THR350
C	ARG370
C	PLP401

---

site_id	AC6
Number of Residues	12
Details	binding site for residue PLP D 600

Chain	Residue
C	TYR54
C	ARG56
D	SER83
D	GLY84
D	MET85
D	TYR108
D	ASN156
D	ASP181
D	SER203
D	THR205
D	LYS206
D	VAL215

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Functional Information from PROSITE/UniProt

site_id	PS00868
Number of Residues	15
Details	CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DLvlhSATKYLnGHS

Chain	Residue	Details
A	ASP198-SER212

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