6K1L
E53A mutant of a putative cystathionine gamma-lyase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000096 | biological_process | sulfur amino acid metabolic process |
| A | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| A | 0004123 | molecular_function | cystathionine gamma-lyase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016846 | molecular_function | carbon-sulfur lyase activity |
| A | 0019346 | biological_process | transsulfuration |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0000096 | biological_process | sulfur amino acid metabolic process |
| B | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| B | 0004123 | molecular_function | cystathionine gamma-lyase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016846 | molecular_function | carbon-sulfur lyase activity |
| B | 0019346 | biological_process | transsulfuration |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0000096 | biological_process | sulfur amino acid metabolic process |
| C | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| C | 0004123 | molecular_function | cystathionine gamma-lyase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016846 | molecular_function | carbon-sulfur lyase activity |
| C | 0019346 | biological_process | transsulfuration |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0000096 | biological_process | sulfur amino acid metabolic process |
| D | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| D | 0004123 | molecular_function | cystathionine gamma-lyase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016846 | molecular_function | carbon-sulfur lyase activity |
| D | 0019346 | biological_process | transsulfuration |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue PLP A 600 |
| Chain | Residue |
| A | SER83 |
| B | TYR54 |
| B | ARG56 |
| A | GLY84 |
| A | MET85 |
| A | TYR108 |
| A | ASP181 |
| A | SER203 |
| A | THR205 |
| A | LYS206 |
| A | GLY216 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue PLP B 401 |
| Chain | Residue |
| A | TYR54 |
| A | ARG56 |
| B | SER83 |
| B | GLY84 |
| B | MET85 |
| B | TYR108 |
| B | ASP181 |
| B | SER203 |
| B | THR205 |
| B | LYS206 |
| B | PYR402 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue PYR B 402 |
| Chain | Residue |
| B | TYR108 |
| B | ASN156 |
| B | LYS206 |
| B | GLU334 |
| B | SER335 |
| B | THR350 |
| B | ARG370 |
| B | PLP401 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue PLP C 401 |
| Chain | Residue |
| C | SER83 |
| C | GLY84 |
| C | MET85 |
| C | TYR108 |
| C | GLU152 |
| C | ASP181 |
| C | SER203 |
| C | THR205 |
| C | LYS206 |
| C | PYR402 |
| D | TYR54 |
| D | ARG56 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue PYR C 402 |
| Chain | Residue |
| C | TYR108 |
| C | ASN156 |
| C | LYS206 |
| C | GLU334 |
| C | SER335 |
| C | LEU336 |
| C | THR350 |
| C | ARG370 |
| C | PLP401 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue PLP D 600 |
| Chain | Residue |
| C | TYR54 |
| C | ARG56 |
| D | SER83 |
| D | GLY84 |
| D | MET85 |
| D | TYR108 |
| D | ASN156 |
| D | ASP181 |
| D | SER203 |
| D | THR205 |
| D | LYS206 |
| D | VAL215 |
Functional Information from PROSITE/UniProt
| site_id | PS00868 |
| Number of Residues | 15 |
| Details | CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DLvlhSATKYLnGHS |
| Chain | Residue | Details |
| A | ASP198-SER212 |
