6K0X

Structure of N6AMT1-TRMT112 Complex with SAM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0006325	biological_process	chromatin organization
A	0008168	molecular_function	methyltransferase activity
A	0008276	molecular_function	protein methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
A	0009404	biological_process	toxin metabolic process
A	0016740	molecular_function	transferase activity
A	0018364	biological_process	peptidyl-glutamine methylation
A	0018872	biological_process	arsonoacetate metabolic process
A	0030307	biological_process	positive regulation of cell growth
A	0030791	molecular_function	arsenite methyltransferase activity
A	0032259	biological_process	methylation
A	0032775	biological_process	obsolete DNA methylation on adenine
A	0032991	cellular_component	protein-containing complex
A	0035657	cellular_component	eRF1 methyltransferase complex
A	0036009	molecular_function	protein-glutamine N-methyltransferase activity
A	0042054	molecular_function	histone methyltransferase activity
A	0045814	biological_process	negative regulation of gene expression, epigenetic
A	0045815	biological_process	transcription initiation-coupled chromatin remodeling
A	0140984	molecular_function	histone H4K12 methyltransferase activity
A	1904047	molecular_function	S-adenosyl-L-methionine binding
B	0000470	biological_process	maturation of LSU-rRNA
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006364	biological_process	rRNA processing
B	0008276	molecular_function	protein methyltransferase activity
B	0018364	biological_process	peptidyl-glutamine methylation
B	0030488	biological_process	tRNA methylation
B	0030490	biological_process	maturation of SSU-rRNA
B	0031167	biological_process	rRNA methylation
B	0032991	cellular_component	protein-containing complex
B	0043528	cellular_component	tRNA (m2G10) methyltransferase complex
B	0045815	biological_process	transcription initiation-coupled chromatin remodeling
B	0046982	molecular_function	protein heterodimerization activity
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0070476	biological_process	rRNA (guanine-N7)-methylation
B	0141106	molecular_function	tRNA methyltransferase activator activity
B	2000234	biological_process	positive regulation of rRNA processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue SAM A 301

Chain	Residue
A	TYR23
A	THR102
A	ASP103
A	LEU104
A	ASN122
A	PRO123
A	PRO124
A	ALA140
A	ALA141
A	HOH403
A	HOH415
A	THR29
A	HOH430
A	HOH435
A	GLU51
A	GLY53
A	SER54
A	GLY55
A	VAL59
A	ASP77
A	ILE78

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Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. LVFNPPY

Chain	Residue	Details
A	LEU119-TYR125

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31636962","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32969463","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K0X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KMS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31636962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KMS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	117
Details	Domain: {"description":"TRM112"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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