Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JVB

Crystal Structure of Human CRMP2 1-532, AGE-modified

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004157	molecular_function	dihydropyrimidinase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006208	biological_process	pyrimidine nucleobase catabolic process
A	0006897	biological_process	endocytosis
A	0007010	biological_process	cytoskeleton organization
A	0007165	biological_process	signal transduction
A	0007399	biological_process	nervous system development
A	0015630	cellular_component	microtubule cytoskeleton
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A	0030154	biological_process	cell differentiation
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
A	0072686	cellular_component	mitotic spindle
A	0120025	cellular_component	plasma membrane bounded cell projection
B	0004157	molecular_function	dihydropyrimidinase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006208	biological_process	pyrimidine nucleobase catabolic process
B	0006897	biological_process	endocytosis
B	0007010	biological_process	cytoskeleton organization
B	0007165	biological_process	signal transduction
B	0007399	biological_process	nervous system development
B	0015630	cellular_component	microtubule cytoskeleton
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B	0030154	biological_process	cell differentiation
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
B	0072686	cellular_component	mitotic spindle
B	0120025	cellular_component	plasma membrane bounded cell projection
C	0004157	molecular_function	dihydropyrimidinase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006208	biological_process	pyrimidine nucleobase catabolic process
C	0006897	biological_process	endocytosis
C	0007010	biological_process	cytoskeleton organization
C	0007165	biological_process	signal transduction
C	0007399	biological_process	nervous system development
C	0015630	cellular_component	microtubule cytoskeleton
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C	0030154	biological_process	cell differentiation
C	0042802	molecular_function	identical protein binding
C	0070062	cellular_component	extracellular exosome
C	0072686	cellular_component	mitotic spindle
C	0120025	cellular_component	plasma membrane bounded cell projection
D	0004157	molecular_function	dihydropyrimidinase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006208	biological_process	pyrimidine nucleobase catabolic process
D	0006897	biological_process	endocytosis
D	0007010	biological_process	cytoskeleton organization
D	0007165	biological_process	signal transduction
D	0007399	biological_process	nervous system development
D	0015630	cellular_component	microtubule cytoskeleton
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D	0030154	biological_process	cell differentiation
D	0042802	molecular_function	identical protein binding
D	0070062	cellular_component	extracellular exosome
D	0072686	cellular_component	mitotic spindle
D	0120025	cellular_component	plasma membrane bounded cell projection

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by FYN","evidences":[{"source":"PubMed","id":"19652227","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O08553","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P47942","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O08553","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O08553","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P47942","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)