Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JTK

Crystal structure of NagZ from Neisseria gonorrhoeae in complex with N-trifluoroacetyl-D-glucosamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004563	molecular_function	beta-N-acetylhexosaminidase activity
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0008360	biological_process	regulation of cell shape
A	0009252	biological_process	peptidoglycan biosynthetic process
A	0009254	biological_process	peptidoglycan turnover
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0051301	biological_process	cell division
A	0071555	biological_process	cell wall organization
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0004563	molecular_function	beta-N-acetylhexosaminidase activity
B	0005737	cellular_component	cytoplasm
B	0005975	biological_process	carbohydrate metabolic process
B	0008360	biological_process	regulation of cell shape
B	0009252	biological_process	peptidoglycan biosynthetic process
B	0009254	biological_process	peptidoglycan turnover
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0051301	biological_process	cell division
B	0071555	biological_process	cell wall organization
C	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
C	0004563	molecular_function	beta-N-acetylhexosaminidase activity
C	0005737	cellular_component	cytoplasm
C	0005975	biological_process	carbohydrate metabolic process
C	0008360	biological_process	regulation of cell shape
C	0009252	biological_process	peptidoglycan biosynthetic process
C	0009254	biological_process	peptidoglycan turnover
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0051301	biological_process	cell division
C	0071555	biological_process	cell wall organization
D	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
D	0004563	molecular_function	beta-N-acetylhexosaminidase activity
D	0005737	cellular_component	cytoplasm
D	0005975	biological_process	carbohydrate metabolic process
D	0008360	biological_process	regulation of cell shape
D	0009252	biological_process	peptidoglycan biosynthetic process
D	0009254	biological_process	peptidoglycan turnover
D	0016787	molecular_function	hydrolase activity
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0051301	biological_process	cell division
D	0071555	biological_process	cell wall organization
E	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
E	0004563	molecular_function	beta-N-acetylhexosaminidase activity
E	0005737	cellular_component	cytoplasm
E	0005975	biological_process	carbohydrate metabolic process
E	0008360	biological_process	regulation of cell shape
E	0009252	biological_process	peptidoglycan biosynthetic process
E	0009254	biological_process	peptidoglycan turnover
E	0016787	molecular_function	hydrolase activity
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0051301	biological_process	cell division
E	0071555	biological_process	cell wall organization
F	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
F	0004563	molecular_function	beta-N-acetylhexosaminidase activity
F	0005737	cellular_component	cytoplasm
F	0005975	biological_process	carbohydrate metabolic process
F	0008360	biological_process	regulation of cell shape
F	0009252	biological_process	peptidoglycan biosynthetic process
F	0009254	biological_process	peptidoglycan turnover
F	0016787	molecular_function	hydrolase activity
F	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
F	0051301	biological_process	cell division
F	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue C76 A 401

Chain	Residue
A	ILE37
C	ASP185
C	SER186
A	ASP69
A	ILE141
A	ARG144
A	LYS174
A	HIS175
A	HIS179
A	ASP258
A	HOH526

site_id	AC2
Number of Residues	13
Details	binding site for residue C76 B 401

Chain	Residue
B	ASP69
B	ILE141
B	ARG144
B	LYS174
B	HIS175
B	HIS179
B	HOH508
B	HOH551
B	HOH641
B	HOH650
B	HOH662
F	ASP185
F	SER186

site_id	AC3
Number of Residues	9
Details	binding site for residue C76 C 401

Chain	Residue
A	ASP185
C	ASP69
C	ILE141
C	ARG144
C	LYS174
C	HIS175
C	HIS179
C	HOH510
C	HOH523

site_id	AC4
Number of Residues	10
Details	binding site for residue C76 D 401

Chain	Residue
D	ILE37
D	ASP69
D	ILE141
D	ARG144
D	LYS174
D	HIS175
D	HIS179
D	HOH529
E	ASP185
E	SER186

Functional Information from PROSITE/UniProt

site_id	PS00775
Number of Residues	18
Details	GLYCOSYL_HYDROL_F3 Glycosyl hydrolases family 3 active site. ILRrDigfkGVIFSDdlT

Chain	Residue	Details
A	ILE244-THR261

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00364","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00364","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_00364","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	5
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00364","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)