Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JT9

Crystal Structure of D464A mutant of FGAM Synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 1301

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP1316
A	HOH1598
A	HOH1610

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 1302

Chain	Residue
A	HOH1655
A	HOH1696
A	HOH1784
A	GLU718
A	ADP1316
A	HOH1477

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 1303

Chain	Residue
A	ADP1316
A	HOH1457
A	HOH1508
A	HOH1745
A	HOH1857

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 1304

Chain	Residue
A	ARG812
A	LYS1228
A	VAL1229
A	HOH1429
A	HOH1550
A	HOH1777

site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 A 1305

Chain	Residue
A	GLN1176
A	GLN1183
A	GLY1184
A	MET1185
A	VAL1186
A	HOH1453
A	HOH1487

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 A 1306

Chain	Residue
A	PRO1040
A	LYS1041
A	HIS1086
A	HOH1507
A	HOH1666
A	HOH1808
A	HOH2078

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 A 1307

Chain	Residue
A	HIS1086
A	ARG1126
A	PRO1127
A	GLN1128
A	THR1129
A	HOH1642
A	HOH1960

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 A 1308

Chain	Residue
A	THR632
A	ILE633
A	HOH1449
A	HOH1800

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 A 1309

Chain	Residue
A	LYS833
A	HIS835
A	ARG858
A	HOH1623

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 A 1310

Chain	Residue
A	ASN1251
A	ARG1253
A	HOH1455

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 A 1311

Chain	Residue
A	ALA911
A	HIS953
A	TYR954
A	GOL1323
A	HOH1533
A	HOH1731

site_id	AD3
Number of Residues	5
Details	binding site for residue SO4 A 1312

Chain	Residue
A	SER12
A	ALA13
A	PHE14
A	ASN998
A	HIS1161

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 A 1313

Chain	Residue
A	PRO356
A	GLU357
A	ARG358
A	HOH1426

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 A 1314

Chain	Residue
A	THR295
A	ASN297
A	HIS298
A	PRO299
A	LYS409
A	SER778

site_id	AD6
Number of Residues	2
Details	binding site for residue SO4 A 1315

Chain	Residue
A	HIS153
A	GLN154

site_id	AD7
Number of Residues	33
Details	binding site for residue ADP A 1316

Chain	Residue
A	HOH1508
A	HOH1598
A	HOH1610
A	HOH1641
A	HOH1655
A	HOH1659
A	HOH1696
A	HOH1722
A	HOH1745
A	HOH1784
A	HOH1857
A	HOH1962
A	VAL333
A	THR386
A	GLY387
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	VAL653
A	GLN668
A	PRO676
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	MG1301
A	MG1302
A	MG1303
A	HOH1457
A	HOH1490
A	HOH1493

site_id	AD8
Number of Residues	5
Details	binding site for residue GOL A 1317

Chain	Residue
A	ASN836
A	GLY913
A	ASP914
A	ASP915
A	HOH1583

site_id	AD9
Number of Residues	4
Details	binding site for residue GOL A 1318

Chain	Residue
A	HIS1125
A	PRO1149
A	GLY1150
A	GLU1152

site_id	AE1
Number of Residues	5
Details	binding site for residue GOL A 1319

Chain	Residue
A	GLN767
A	ASP859
A	VAL860
A	ALA861
A	HOH1518

site_id	AE2
Number of Residues	5
Details	binding site for residue GOL A 1320

Chain	Residue
A	ARG1159
A	ARG1164
A	PHE1165
A	HOH1541
A	HOH1870

site_id	AE3
Number of Residues	4
Details	binding site for residue GOL A 1321

Chain	Residue
A	LEU626
A	ARG628
A	ASP852
A	HOH1961

site_id	AE4
Number of Residues	6
Details	binding site for residue GOL A 1322

Chain	Residue
A	PHE282
A	ALA1058
A	HIS1061
A	ARG1062
A	HOH1654
A	HOH1973

site_id	AE5
Number of Residues	4
Details	binding site for residue GOL A 1323

Chain	Residue
A	ARG936
A	TYR954
A	SO41311
A	HOH2050

site_id	AE6
Number of Residues	4
Details	binding site for residue GOL A 1324

Chain	Residue
A	HIS746
A	PRO747
A	ARG784
A	GLU793

site_id	AE7
Number of Residues	2
Details	binding site for residue CL A 1325

Chain	Residue
A	ASN1018
A	VAL1019

site_id	AE8
Number of Residues	1
Details	binding site for residue CL A 1326

Chain	Residue
A	HIS68

site_id	AE9
Number of Residues	1
Details	binding site for residue CL A 1327

Chain	Residue
A	ARG1115

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	CYG1135

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	HIS1260
A	GLU1262

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	GLY307

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	THR386
A	ALA678
A	SER886

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419, ECO:0000269\|PubMed:15301531, ECO:0000269\|PubMed:22683785, ECO:0000269\|PubMed:24223728

Chain	Residue	Details
A	ASP679
A	GLU718
A	ASN722
A	ASP884

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)