Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JOD

Angiotensin II type 2 receptor with ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004945	molecular_function	angiotensin type II receptor activity
A	0006954	biological_process	inflammatory response
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0042981	biological_process	regulation of apoptotic process
A	0097746	biological_process	blood vessel diameter maintenance
C	0005506	molecular_function	iron ion binding
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0022900	biological_process	electron transport chain
C	0042597	cellular_component	periplasmic space

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIfFITCMSVDRYQsV

Chain	Residue	Details
A	ALA130-VAL146

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR191-HIS197

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	51
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	45
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	9
Details	Region: {"description":"Helix VIII","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	7
Details	Peptide: {"description":"Angiotensin-2","featureId":"PRO_0000032458","evidences":[{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9492317","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	6
Details	Peptide: {"description":"Angiotensin 1-7","featureId":"PRO_0000420660","evidences":[{"source":"PubMed","id":"15283675","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Peptide: {"description":"Angiotensin 1-5","featureId":"PRO_0000420661","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	3
Details	Peptide: {"description":"Angiotensin 1-4","featureId":"PRO_0000420662","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	6
Details	Peptide: {"description":"Angiotensin-3","featureId":"PRO_0000032459","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"1132082","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	5
Details	Peptide: {"description":"Angiotensin-4","featureId":"PRO_0000420663","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Beta-decarboxylated aspartate; in form angiotensin-A","evidences":[{"source":"PubMed","id":"17138938","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)