6JMF
Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 4
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 901 |
| Chain | Residue |
| A | ARG682 |
| A | ARG706 |
| A | TYR713 |
| A | ALA715 |
| A | SER716 |
| A | HOH1110 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 902 |
| Chain | Residue |
| A | LYS488 |
| A | ARG467 |
| A | ARG483 |
| A | SER485 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue 9FC A 903 |
| Chain | Residue |
| A | ILE567 |
| A | ARG569 |
| A | ALA588 |
| A | LYS590 |
| A | MET636 |
| A | GLU637 |
| A | LEU638 |
| A | VAL639 |
| A | GLN640 |
| A | GLY642 |
| A | ARG687 |
| A | ASN688 |
| A | LEU690 |
| A | SER700 |
| A | ASP701 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGNFGEVFsGrlradntl..........VAVK |
| Chain | Residue | Details |
| A | ILE567-LYS590 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNCLV |
| Chain | Residue | Details |
| A | CYS679-VAL691 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 89 |
| Details | Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"15485904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18046454","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18775312","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19382747","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7687763","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
