6JLQ
Crystal structure of human USP46-WDR48-WDR20 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016579 | biological_process | protein deubiquitination |
| A | 0031647 | biological_process | regulation of protein stability |
| A | 0032228 | biological_process | regulation of synaptic transmission, GABAergic |
| A | 0045202 | cellular_component | synapse |
| A | 0090263 | biological_process | positive regulation of canonical Wnt signaling pathway |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099149 | biological_process | regulation of postsynaptic neurotransmitter receptor internalization |
| A | 0101005 | molecular_function | deubiquitinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS182 |
| A | CYS185 |
| A | CYS229 |
| A | THR231 |
| A | CYS232 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | LYS256 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 601 |
| Chain | Residue |
| B | ARG193 |
| B | LYS202 |
| B | LYS205 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 602 |
| Chain | Residue |
| B | SER238 |
| B | GLN241 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| B | MET110 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| B | HIS105 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | ASN261 |
| B | HIS266 |
| B | TYR268 |
| B | PRO309 |
| B | HIS330 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 606 |
| Chain | Residue |
| B | ARG139 |
| B | LEU164 |
| B | SER165 |
| B | GLY166 |
| B | ASN167 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue GOL B 607 |
| Chain | Residue |
| B | ARG274 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 601 |
| Chain | Residue |
| C | ASP63 |
| C | LEU542 |
| C | ASP544 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LISAssDtTVKVWNA |
| Chain | Residue | Details |
| B | LEU90-ALA104 | |
| B | VAL132-VAL146 |
| site_id | PS00972 |
| Number of Residues | 16 |
| Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLvnfGNtCYCNSvLQ |
| Chain | Residue | Details |
| A | GLY36-GLN51 |
| site_id | PS00973 |
| Number of Residues | 19 |
| Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YdLvAVvvHcGsgpnr.GHY |
| Chain | Residue | Details |
| A | TYR296-TYR314 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26388029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22043315","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5CVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L8H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BH57","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 71 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
