6JK6

Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 2-8-s2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process
A	0008061	molecular_function	chitin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue BV0 A 501

Chain	Residue
A	TRP99
A	GLY373
A	BV0502
A	HOH610
A	HOH622
A	HOH647
A	HOH745
A	HOH751
A	ASP138
A	GLU140
A	TYR141
A	TYR190
A	MET210
A	TYR212
A	GLU297
A	TRP358

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site_id	AC2
Number of Residues	5
Details	binding site for residue BV0 A 502

Chain	Residue
A	TYR190
A	ASP213
A	TRP218
A	ASN371
A	BV0501

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Functional Information from PROSITE/UniProt

site_id	PS01095
Number of Residues	9
Details	GH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. FDGLDLDwE

Chain	Residue	Details
A	PHE132-GLU140

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01258

Chain	Residue	Details
A	GLU140

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01258

Chain	Residue	Details
A	GLU70
A	GLY97
A	TYR141
A	MET210
A	TRP358

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; in variant S-102 => ECO:0000269|PubMed:19725875

Chain	Residue	Details
A	ASN100

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