6JI0

Structure of RyR2 (F/A/C/Ca2+ dataset)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005102	molecular_function	signaling receptor binding
B	0005246	molecular_function	calcium channel regulator activity
B	0005515	molecular_function	protein binding
B	0005528	molecular_function	FK506 binding
B	0005737	cellular_component	cytoplasm
B	0006457	biological_process	protein folding
B	0006458	biological_process	'de novo' protein folding
B	0010459	biological_process	negative regulation of heart rate
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0016853	molecular_function	isomerase activity
B	0019722	biological_process	calcium-mediated signaling
B	0019855	molecular_function	calcium channel inhibitor activity
B	0030018	cellular_component	Z disc
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0034704	cellular_component	calcium channel complex
B	0042026	biological_process	protein refolding
B	0044325	molecular_function	transmembrane transporter binding
B	0050849	biological_process	negative regulation of calcium-mediated signaling
B	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
B	0051604	biological_process	protein maturation
B	0051775	biological_process	response to redox state
B	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
C	0005262	molecular_function	calcium channel activity
C	0005509	molecular_function	calcium ion binding
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0005102	molecular_function	signaling receptor binding
D	0005246	molecular_function	calcium channel regulator activity
D	0005515	molecular_function	protein binding
D	0005528	molecular_function	FK506 binding
D	0005737	cellular_component	cytoplasm
D	0006457	biological_process	protein folding
D	0006458	biological_process	'de novo' protein folding
D	0010459	biological_process	negative regulation of heart rate
D	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D	0016020	cellular_component	membrane
D	0016529	cellular_component	sarcoplasmic reticulum
D	0016853	molecular_function	isomerase activity
D	0019722	biological_process	calcium-mediated signaling
D	0019855	molecular_function	calcium channel inhibitor activity
D	0030018	cellular_component	Z disc
D	0033017	cellular_component	sarcoplasmic reticulum membrane
D	0034704	cellular_component	calcium channel complex
D	0042026	biological_process	protein refolding
D	0044325	molecular_function	transmembrane transporter binding
D	0050849	biological_process	negative regulation of calcium-mediated signaling
D	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
D	0051604	biological_process	protein maturation
D	0051775	biological_process	response to redox state
D	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
E	0005262	molecular_function	calcium channel activity
E	0005509	molecular_function	calcium ion binding
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0006874	biological_process	intracellular calcium ion homeostasis
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport
E	0070588	biological_process	calcium ion transmembrane transport
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005102	molecular_function	signaling receptor binding
F	0005246	molecular_function	calcium channel regulator activity
F	0005515	molecular_function	protein binding
F	0005528	molecular_function	FK506 binding
F	0005737	cellular_component	cytoplasm
F	0006457	biological_process	protein folding
F	0006458	biological_process	'de novo' protein folding
F	0010459	biological_process	negative regulation of heart rate
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0016529	cellular_component	sarcoplasmic reticulum
F	0016853	molecular_function	isomerase activity
F	0019722	biological_process	calcium-mediated signaling
F	0019855	molecular_function	calcium channel inhibitor activity
F	0030018	cellular_component	Z disc
F	0033017	cellular_component	sarcoplasmic reticulum membrane
F	0034704	cellular_component	calcium channel complex
F	0042026	biological_process	protein refolding
F	0044325	molecular_function	transmembrane transporter binding
F	0050849	biological_process	negative regulation of calcium-mediated signaling
F	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
F	0051604	biological_process	protein maturation
F	0051775	biological_process	response to redox state
F	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
G	0005262	molecular_function	calcium channel activity
G	0005509	molecular_function	calcium ion binding
G	0006811	biological_process	monoatomic ion transport
G	0006816	biological_process	calcium ion transport
G	0006874	biological_process	intracellular calcium ion homeostasis
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport
G	0070588	biological_process	calcium ion transmembrane transport
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005102	molecular_function	signaling receptor binding
H	0005246	molecular_function	calcium channel regulator activity
H	0005515	molecular_function	protein binding
H	0005528	molecular_function	FK506 binding
H	0005737	cellular_component	cytoplasm
H	0006457	biological_process	protein folding
H	0006458	biological_process	'de novo' protein folding
H	0010459	biological_process	negative regulation of heart rate
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016529	cellular_component	sarcoplasmic reticulum
H	0016853	molecular_function	isomerase activity
H	0019722	biological_process	calcium-mediated signaling
H	0019855	molecular_function	calcium channel inhibitor activity
H	0030018	cellular_component	Z disc
H	0033017	cellular_component	sarcoplasmic reticulum membrane
H	0034704	cellular_component	calcium channel complex
H	0042026	biological_process	protein refolding
H	0044325	molecular_function	transmembrane transporter binding
H	0050849	biological_process	negative regulation of calcium-mediated signaling
H	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
H	0051604	biological_process	protein maturation
H	0051775	biological_process	response to redox state
H	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 5100

Chain	Residue
A	CYS4889
A	ILE4891
A	CYS4892
A	HIS4909
A	HIS4914

---

site_id	AC2
Number of Residues	11
Details	binding site for residue ATP A 5101

Chain	Residue
A	GLU4886
A	CYS4889
A	PHE4890
A	ILE4891
A	PHE4906
A	THR4910
A	LEU4916
A	LYS4167
A	LYS4170
A	ARG4171
A	MET4885

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CA A 5102

Chain	Residue
A	GLU3849
A	GLU3923
A	THR4932

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CFF A 5103

Chain	Residue
A	PHE3715
A	TRP4646
A	ILE4927
A	TRP4942
A	TYR4945

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN C 5100

Chain	Residue
C	CYS4889
C	ILE4891
C	CYS4892
C	HIS4909
C	HIS4914

---

site_id	AC6
Number of Residues	11
Details	binding site for residue ATP C 5101

Chain	Residue
C	LYS4167
C	LYS4170
C	ARG4171
C	MET4885
C	GLU4886
C	CYS4889
C	PHE4890
C	ILE4891
C	PHE4906
C	THR4910
C	LEU4916

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CA C 5102

Chain	Residue
C	GLU3849
C	GLU3923
C	THR4932

---

site_id	AC8
Number of Residues	5
Details	binding site for residue CFF C 5103

Chain	Residue
C	PHE3715
C	TRP4646
C	ILE4927
C	TRP4942
C	TYR4945

---

site_id	AC9
Number of Residues	5
Details	binding site for residue ZN E 5100

Chain	Residue
E	CYS4889
E	ILE4891
E	CYS4892
E	HIS4909
E	HIS4914

---

site_id	AD1
Number of Residues	11
Details	binding site for residue ATP E 5101

Chain	Residue
E	LYS4167
E	LYS4170
E	ARG4171
E	MET4885
E	GLU4886
E	CYS4889
E	PHE4890
E	ILE4891
E	PHE4906
E	THR4910
E	LEU4916

---

site_id	AD2
Number of Residues	3
Details	binding site for residue CA E 5102

Chain	Residue
E	GLU3849
E	GLU3923
E	THR4932

---

site_id	AD3
Number of Residues	5
Details	binding site for residue CFF E 5103

Chain	Residue
E	PHE3715
E	TRP4646
E	ILE4927
E	TRP4942
E	TYR4945

---

site_id	AD4
Number of Residues	5
Details	binding site for residue ZN G 5100

Chain	Residue
G	CYS4889
G	ILE4891
G	CYS4892
G	HIS4909
G	HIS4914

---

site_id	AD5
Number of Residues	11
Details	binding site for residue ATP G 5101

Chain	Residue
G	LYS4167
G	LYS4170
G	ARG4171
G	MET4885
G	GLU4886
G	CYS4889
G	PHE4890
G	ILE4891
G	PHE4906
G	THR4910
G	LEU4916

---

site_id	AD6
Number of Residues	3
Details	binding site for residue CA G 5102

Chain	Residue
G	GLU3849
G	GLU3923
G	THR4932

---

site_id	AD7
Number of Residues	5
Details	binding site for residue CFF G 5103

Chain	Residue
G	PHE3715
G	TRP4646
G	ILE4927
G	TRP4942
G	TYR4945

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	352
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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