6JD2
Crystal structure of Sulfolobus solfataricus ketol-acid reductoisomerase (Sso-KARI) in complex with Mg2+ at pH8.5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0009099 | biological_process | L-valine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0009099 | biological_process | L-valine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| C | 0009097 | biological_process | isoleucine biosynthetic process |
| C | 0009099 | biological_process | L-valine biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| D | 0009097 | biological_process | isoleucine biosynthetic process |
| D | 0009099 | biological_process | L-valine biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| E | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| E | 0009097 | biological_process | isoleucine biosynthetic process |
| E | 0009099 | biological_process | L-valine biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| F | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| F | 0009097 | biological_process | isoleucine biosynthetic process |
| F | 0009099 | biological_process | L-valine biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| G | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| G | 0009097 | biological_process | isoleucine biosynthetic process |
| G | 0009099 | biological_process | L-valine biosynthetic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| H | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| H | 0009097 | biological_process | isoleucine biosynthetic process |
| H | 0009099 | biological_process | L-valine biosynthetic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| I | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| I | 0008652 | biological_process | amino acid biosynthetic process |
| I | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| I | 0009097 | biological_process | isoleucine biosynthetic process |
| I | 0009099 | biological_process | L-valine biosynthetic process |
| I | 0016491 | molecular_function | oxidoreductase activity |
| J | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| J | 0008652 | biological_process | amino acid biosynthetic process |
| J | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| J | 0009097 | biological_process | isoleucine biosynthetic process |
| J | 0009099 | biological_process | L-valine biosynthetic process |
| J | 0016491 | molecular_function | oxidoreductase activity |
| K | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| K | 0008652 | biological_process | amino acid biosynthetic process |
| K | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| K | 0009097 | biological_process | isoleucine biosynthetic process |
| K | 0009099 | biological_process | L-valine biosynthetic process |
| K | 0016491 | molecular_function | oxidoreductase activity |
| L | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| L | 0008652 | biological_process | amino acid biosynthetic process |
| L | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| L | 0009097 | biological_process | isoleucine biosynthetic process |
| L | 0009099 | biological_process | L-valine biosynthetic process |
| L | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue BME A 401 |
| Chain | Residue |
| A | GLU279 |
| A | HOH605 |
| B | ARG264 |
| B | LYS267 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ASP191 |
| A | GLU195 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | GLU227 |
| A | GLU233 |
| B | ASP191 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 404 |
| Chain | Residue |
| A | ASP191 |
| B | GLU227 |
| B | GLU233 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue BME B 401 |
| Chain | Residue |
| A | ARG264 |
| A | LYS267 |
| A | HOH620 |
| B | GLU279 |
| B | HOH505 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | ASP191 |
| B | GLU195 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue BME C 500 |
| Chain | Residue |
| C | GLU279 |
| D | ARG264 |
| D | LYS267 |
| D | HOH522 |
| D | HOH533 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 501 |
| Chain | Residue |
| C | ASP191 |
| C | GLU195 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue MG C 502 |
| Chain | Residue |
| C | GLU227 |
| C | GLU233 |
| D | ASP191 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 401 |
| Chain | Residue |
| C | ASP191 |
| D | GLU227 |
| D | GLU233 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue BME D 402 |
| Chain | Residue |
| C | ARG264 |
| C | LYS267 |
| D | GLU279 |
| D | TYR282 |
| D | HOH518 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 403 |
| Chain | Residue |
| C | SER254 |
| D | ASP191 |
| D | GLU195 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue BME E 500 |
| Chain | Residue |
| E | GLU279 |
| E | HOH602 |
| F | ARG264 |
| F | LYS267 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue MG E 501 |
| Chain | Residue |
| E | ASP191 |
| E | GLU195 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue MG E 502 |
| Chain | Residue |
| E | GLU227 |
| E | GLU233 |
| E | HOH601 |
| E | HOH613 |
| F | ASP191 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue MG F 401 |
| Chain | Residue |
| E | ASP191 |
| F | GLU227 |
| F | GLU233 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue BME F 402 |
| Chain | Residue |
| E | ARG264 |
| E | LYS267 |
| E | HOH625 |
| F | GLU279 |
| F | TYR282 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue MG F 403 |
| Chain | Residue |
| E | SER254 |
| F | ASP191 |
| F | GLU195 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue BME G 500 |
| Chain | Residue |
| G | GLU279 |
| G | HOH604 |
| G | HOH627 |
| H | ARG264 |
| H | LYS267 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue MG G 501 |
| Chain | Residue |
| G | ASP191 |
| G | GLU195 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue MG G 502 |
| Chain | Residue |
| G | GLU227 |
| G | GLU233 |
| H | ASP191 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue MG H 401 |
| Chain | Residue |
| G | ASP191 |
| H | GLU227 |
| H | GLU233 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue BME H 402 |
| Chain | Residue |
| G | ARG264 |
| H | ASN278 |
| H | GLU279 |
| H | TYR282 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue MG H 403 |
| Chain | Residue |
| H | ASP191 |
| H | GLU195 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue BME I 500 |
| Chain | Residue |
| I | GLU279 |
| I | HOH603 |
| J | ARG264 |
| J | LYS267 |
| site_id | AE8 |
| Number of Residues | 2 |
| Details | binding site for residue MG I 501 |
| Chain | Residue |
| I | ASP191 |
| I | GLU195 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue MG I 502 |
| Chain | Residue |
| I | GLU227 |
| I | GLU233 |
| J | ASP191 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue MG J 401 |
| Chain | Residue |
| I | ASP191 |
| J | GLU227 |
| J | GLU233 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue BME J 402 |
| Chain | Residue |
| I | ARG264 |
| I | LYS267 |
| J | GLU279 |
| J | HOH533 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue MG J 403 |
| Chain | Residue |
| J | ASP191 |
| J | GLU195 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue BME K 500 |
| Chain | Residue |
| K | GLU279 |
| K | HOH660 |
| L | ARG264 |
| L | LYS267 |
| L | HOH554 |
| site_id | AF5 |
| Number of Residues | 2 |
| Details | binding site for residue MG K 501 |
| Chain | Residue |
| K | ASP191 |
| K | GLU195 |
| site_id | AF6 |
| Number of Residues | 3 |
| Details | binding site for residue MG K 502 |
| Chain | Residue |
| K | GLU227 |
| K | GLU233 |
| L | ASP191 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue MG L 401 |
| Chain | Residue |
| K | ASP191 |
| L | GLU227 |
| L | GLU233 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue BME L 402 |
| Chain | Residue |
| K | ARG264 |
| K | LYS267 |
| K | HOH632 |
| L | GLU279 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue MG L 403 |
| Chain | Residue |
| K | SER254 |
| L | ASP191 |
| L | GLU195 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 730 |
| Details | Domain: {"description":"KARI C-terminal knotted","evidences":[{"source":"PROSITE-ProRule","id":"PRU01198","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
