Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JCL

Crystal structure of cofactor-bound Rv0187 from MTB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008168	molecular_function	methyltransferase activity
A	0008171	molecular_function	O-methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0016206	molecular_function	catechol O-methyltransferase activity
A	0032259	biological_process	methylation
A	0046872	molecular_function	metal ion binding
B	0005886	cellular_component	plasma membrane
B	0008168	molecular_function	methyltransferase activity
B	0008171	molecular_function	O-methyltransferase activity
B	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
B	0016206	molecular_function	catechol O-methyltransferase activity
B	0032259	biological_process	methylation
B	0046872	molecular_function	metal ion binding
C	0005886	cellular_component	plasma membrane
C	0008168	molecular_function	methyltransferase activity
C	0008171	molecular_function	O-methyltransferase activity
C	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
C	0016206	molecular_function	catechol O-methyltransferase activity
C	0032259	biological_process	methylation
C	0046872	molecular_function	metal ion binding
D	0005886	cellular_component	plasma membrane
D	0008168	molecular_function	methyltransferase activity
D	0008171	molecular_function	O-methyltransferase activity
D	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
D	0016206	molecular_function	catechol O-methyltransferase activity
D	0032259	biological_process	methylation
D	0046872	molecular_function	metal ion binding
E	0005886	cellular_component	plasma membrane
E	0008168	molecular_function	methyltransferase activity
E	0008171	molecular_function	O-methyltransferase activity
E	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
E	0016206	molecular_function	catechol O-methyltransferase activity
E	0032259	biological_process	methylation
E	0046872	molecular_function	metal ion binding
F	0005886	cellular_component	plasma membrane
F	0008168	molecular_function	methyltransferase activity
F	0008171	molecular_function	O-methyltransferase activity
F	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
F	0016206	molecular_function	catechol O-methyltransferase activity
F	0032259	biological_process	methylation
F	0046872	molecular_function	metal ion binding
G	0005886	cellular_component	plasma membrane
G	0008168	molecular_function	methyltransferase activity
G	0008171	molecular_function	O-methyltransferase activity
G	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
G	0016206	molecular_function	catechol O-methyltransferase activity
G	0032259	biological_process	methylation
G	0046872	molecular_function	metal ion binding
H	0005886	cellular_component	plasma membrane
H	0008168	molecular_function	methyltransferase activity
H	0008171	molecular_function	O-methyltransferase activity
H	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
H	0016206	molecular_function	catechol O-methyltransferase activity
H	0032259	biological_process	methylation
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue SAH A 301

Chain	Residue
A	ALA43
A	GLN94
A	HIS97
A	GLY119
A	PRO120
A	ALA121
A	ASP139
A	ALA140
A	ASP141
A	TYR148
A	HOH431
A	VAL44
A	HOH438
A	HOH464
A	HOH473
A	HOH487
C	HOH476
A	GLY68
A	THR69
A	LEU70
A	PHE73
A	SER74
A	GLU92
A	TYR93

site_id	AC2
Number of Residues	6
Details	binding site for residue SR A 302

Chain	Residue
A	ASP139
A	ASP165
A	ASN166
A	HOH438
C	ASP178
C	HOH444

site_id	AC3
Number of Residues	9
Details	binding site for residue MPD A 303

Chain	Residue
A	VAL44
A	GLN48
A	PHE51
A	LEU52
A	VAL163
A	ASP165
A	PHE214
A	HOH428
A	HOH443

site_id	AC4
Number of Residues	6
Details	binding site for residue SR A 304

Chain	Residue
A	ASP179
A	ASP181
C	ASP179
C	ASP181
C	HOH421
C	HOH508

site_id	AC5
Number of Residues	6
Details	binding site for residue SR A 305

Chain	Residue
A	ASP178
A	HOH475
C	ASP139
C	ASP165
C	ASN166
C	HOH424

site_id	AC6
Number of Residues	21
Details	binding site for residue SAH B 301

Chain	Residue
B	ALA43
B	VAL44
B	GLY68
B	THR69
B	LEU70
B	PHE73
B	SER74
B	GLU92
B	TYR93
B	GLN94
B	HIS97
B	PRO120
B	ALA121
B	ASP139
B	ALA140
B	ASP141
B	TYR148
B	HOH450
B	HOH464
B	HOH466
B	HOH479

site_id	AC7
Number of Residues	6
Details	binding site for residue SR B 302

Chain	Residue
B	ASP139
B	ASP165
B	ASN166
B	HOH450
E	ASP178
E	HOH417

site_id	AC8
Number of Residues	9
Details	binding site for residue MPD B 303

Chain	Residue
A	ILE203
B	VAL44
B	GLN48
B	LEU52
B	VAL163
B	ASP165
B	PHE214
B	HOH424
B	HOH451

site_id	AC9
Number of Residues	3
Details	binding site for residue MPD B 304

Chain	Residue
A	GLN106
B	GLN150
B	TRP151

site_id	AD1
Number of Residues	5
Details	binding site for residue NA B 305

Chain	Residue
B	MET192
B	GLY193
B	HIS195
B	LEU198
B	HOH401

site_id	AD2
Number of Residues	6
Details	binding site for residue SR B 306

Chain	Residue
E	ASN166
E	HOH439
B	ASP178
B	HOH433
E	ASP139
E	ASP165

site_id	AD3
Number of Residues	21
Details	binding site for residue SAH C 301

Chain	Residue
A	GLU143
C	ALA43
C	VAL44
C	GLY68
C	LEU70
C	PHE73
C	SER74
C	GLU92
C	TYR93
C	GLN94
C	HIS97
C	ALA121
C	ASP139
C	ALA140
C	ASP141
C	TYR148
C	HOH424
C	HOH434
C	HOH447
C	HOH453
C	HOH492

site_id	AD4
Number of Residues	10
Details	binding site for residue MPD C 302

Chain	Residue
C	VAL44
C	GLN48
C	PHE51
C	LEU52
C	VAL163
C	ASP165
C	PHE214
C	HOH428
C	HOH443
D	ILE203

site_id	AD5
Number of Residues	20
Details	binding site for residue SAH D 301

Chain	Residue
D	ILE42
D	ALA43
D	VAL44
D	GLY68
D	THR69
D	LEU70
D	PHE73
D	SER74
D	GLU92
D	TYR93
D	GLN94
D	HIS97
D	ALA121
D	ASP139
D	ALA140
D	ASP141
D	TYR148
D	HOH430
D	HOH449
D	HOH456

site_id	AD6
Number of Residues	6
Details	binding site for residue SR D 302

Chain	Residue
D	ASP139
D	ASP165
D	ASN166
D	HOH430
H	ASP178
H	HOH427

site_id	AD7
Number of Residues	10
Details	binding site for residue MPD D 303

Chain	Residue
C	ILE203
D	VAL44
D	GLN48
D	PHE51
D	PHE137
D	VAL163
D	ASP165
D	PHE214
D	HOH428
D	HOH463

site_id	AD8
Number of Residues	6
Details	binding site for residue SR D 304

Chain	Residue
D	ASP178
D	HOH406
H	ASP139
H	ASP165
H	ASN166
H	HOH433

site_id	AD9
Number of Residues	19
Details	binding site for residue SAH G 301

Chain	Residue
G	ALA43
G	VAL44
G	GLY68
G	THR69
G	LEU70
G	PHE73
G	SER74
G	GLU92
G	TYR93
G	HIS97
G	ALA121
G	ASP139
G	ALA140
G	ASP141
G	TYR148
G	HOH422
G	HOH426
G	HOH441
G	HOH450

site_id	AE1
Number of Residues	6
Details	binding site for residue SR G 302

Chain	Residue
F	ASP178
F	HOH415
G	ASP139
G	ASP165
G	ASN166
G	HOH426

site_id	AE2
Number of Residues	11
Details	binding site for residue MPD G 303

Chain	Residue
G	VAL44
G	GLN48
G	PHE51
G	LEU52
G	PHE137
G	VAL163
G	ASP165
G	PHE214
G	HOH432
G	HOH435
H	ILE203

site_id	AE3
Number of Residues	6
Details	binding site for residue SR G 304

Chain	Residue
F	ASP179
F	ASP181
F	HOH482
G	ASP179
G	ASP181
G	HOH445

site_id	AE4
Number of Residues	6
Details	binding site for residue SR G 305

Chain	Residue
F	ASP139
F	ASP165
F	ASN166
F	HOH413
G	ASP178
G	HOH423

site_id	AE5
Number of Residues	19
Details	binding site for residue SAH H 301

Chain	Residue
H	ALA43
H	VAL44
H	GLY68
H	THR69
H	LEU70
H	PHE73
H	SER74
H	GLU92
H	TYR93
H	HIS97
H	GLY119
H	PRO120
H	ALA121
H	ASP139
H	ALA140
H	ASP141
H	TYR148
H	HOH424
H	HOH433

site_id	AE6
Number of Residues	8
Details	binding site for residue MPD H 302

Chain	Residue
G	ILE203
H	GLN48
H	PHE137
H	VAL163
H	ASP165
H	PHE214
H	HOH405
H	HOH453

site_id	AE7
Number of Residues	20
Details	binding site for residue SAH E 301

Chain	Residue
E	ALA43
E	VAL44
E	GLY68
E	LEU70
E	PHE73
E	SER74
E	GLU92
E	TYR93
E	GLN94
E	HIS97
E	GLY119
E	PRO120
E	ALA121
E	ASP139
E	ALA140
E	ASP141
E	TYR148
E	HOH439
E	HOH455
E	HOH477

site_id	AE8
Number of Residues	6
Details	binding site for residue MPD E 302

Chain	Residue
E	GLN48
E	ASP165
E	PHE214
E	HOH423
E	HOH473
F	ILE203

site_id	AE9
Number of Residues	24
Details	binding site for residue SAH F 301

Chain	Residue
F	ILE42
F	ALA43
F	VAL44
F	GLY68
F	THR69
F	LEU70
F	PHE73
F	SER74
F	GLU92
F	TYR93
F	GLN94
F	HIS97
F	GLY119
F	PRO120
F	ALA121
F	ASP139
F	ALA140
F	ASP141
F	TYR148
F	HOH413
F	HOH441
F	HOH453
F	HOH481
G	GLU143

site_id	AF1
Number of Residues	10
Details	binding site for residue MPD F 302

Chain	Residue
E	ILE203
F	VAL44
F	GLN48
F	PHE51
F	LEU52
F	VAL163
F	ASP165
F	PHE214
F	HOH421
F	HOH439

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01019, ECO:0000305\|PubMed:31147608

Chain	Residue	Details
A	VAL44
B	GLU92
B	ALA121
B	ASP141
C	VAL44
C	GLY68
C	SER74
C	GLU92
C	ALA121
C	ASP141
D	VAL44
A	GLY68
D	GLY68
D	SER74
D	GLU92
D	ALA121
D	ASP141
G	VAL44
G	GLY68
G	SER74
G	GLU92
G	ALA121
A	SER74
G	ASP141
H	VAL44
H	GLY68
H	SER74
H	GLU92
H	ALA121
H	ASP141
E	VAL44
E	GLY68
E	SER74
A	GLU92
E	GLU92
E	ALA121
E	ASP141
F	VAL44
F	GLY68
F	SER74
F	GLU92
F	ALA121
F	ASP141
A	ALA121
A	ASP141
B	VAL44
B	GLY68
B	SER74

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01019

Chain	Residue	Details
A	GLU66
B	GLU66
C	GLU66
D	GLU66
G	GLU66
H	GLU66
E	GLU66
F	GLU66

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01019, ECO:0000269\|PubMed:31147608

Chain	Residue	Details
A	ASP139
D	ASP139
D	ASP165
D	ASN166
G	ASP139
G	ASP165
G	ASN166
H	ASP139
H	ASP165
H	ASN166
E	ASP139
A	ASP165
E	ASP165
E	ASN166
F	ASP139
F	ASP165
F	ASN166
A	ASN166
B	ASP139
B	ASP165
B	ASN166
C	ASP139
C	ASP165
C	ASN166

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)