6JAT

Crystal structure of SETD3 bound to Actin peptide and SFG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0018064	molecular_function	protein-L-histidine N-tele-methyltransferase activity
A	0030047	biological_process	actin modification
C	0018064	molecular_function	protein-L-histidine N-tele-methyltransferase activity
C	0030047	biological_process	actin modification

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue SFG A 501

Chain	Residue
A	ARG74
A	ASN277
A	HIS278
A	TYR312
A	SER324
A	PHE326
A	PHE328
B	HIS73
A	GLU103
A	PHE105
A	PRO179
A	THR252
A	ARG253
A	ASP274
A	MET275
A	CYS276

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 502

Chain	Residue
A	TYR195
A	THR442
A	ARG467
A	SO4503

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 503

Chain	Residue
A	ARG194
A	LYS441
A	SO4502

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 504

Chain	Residue
A	PHE367
A	ALA368
A	SER377
A	GLN379

---

site_id	AC5
Number of Residues	15
Details	binding site for residue SFG C 501

Chain	Residue
C	ARG74
C	GLU102
C	GLU103
C	PHE105
C	PRO179
C	ARG253
C	ASP274
C	MET275
C	ASN277
C	HIS278
C	TYR312
C	SER324
C	PHE326
C	PHE328
D	HIS73

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 C 502

Chain	Residue
C	PHE367
C	ALA368
C	SER377
C	GLN379

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 C 503

Chain	Residue
C	ARG347
C	ALA350
C	MET351

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EPE C 504

Chain	Residue
C	TRP46
C	GLN197
C	SER198
C	ILE202
C	PHE206

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	440
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31911441","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31993215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"Crystal structure of human SET domain-containing protein 3.","authors":["Zeng H.","Dong A.","Walker J.R.","Loppnau P.","Bountra C.","Weigelt J.","Arrowsmith C.H.","Edwards A.M.","Min J.","Wu H."]}},{"source":"PDB","id":"3SMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JAT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31993215","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---