6J8G
Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (Y1755 up)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0009791 | biological_process | post-embryonic development |
| A | 0016020 | cellular_component | membrane |
| A | 0019228 | biological_process | neuronal action potential |
| A | 0019233 | biological_process | sensory perception of pain |
| A | 0030424 | cellular_component | axon |
| A | 0033268 | cellular_component | node of Ranvier |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042995 | cellular_component | cell projection |
| A | 0043679 | cellular_component | axon terminus |
| A | 0048266 | biological_process | behavioral response to pain |
| A | 0050965 | biological_process | detection of temperature stimulus involved in sensory perception of pain |
| A | 0050974 | biological_process | detection of mechanical stimulus involved in sensory perception |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
| A | 0098870 | biological_process | action potential propagation |
| B | 0001518 | cellular_component | voltage-gated sodium channel complex |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0017080 | molecular_function | sodium channel regulator activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:30190309 |
| Chain | Residue | Details |
| B | GLY19-ILE157 | |
| A | GLY1454-ALA1516 | |
| A | LYS1565-VAL1576 | |
| A | LYS1625-ALA1643 | |
| A | LEU1760-LYS1988 | |
| A | ARG174-PRO187 | |
| A | PRO229-ASP247 | |
| A | VAL400-PRO744 | |
| A | LEU795-TRP808 | |
| A | TRP849-GLY864 | |
| A | LEU968-TRP1193 | |
| A | LYS1244-ALA1257 | |
| A | PHE1304-SER1320 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:30190309, ECO:0007744|PDB:6AGF |
| Chain | Residue | Details |
| B | VAL158-ILE179 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:30190309 |
| Chain | Residue | Details |
| B | TYR180-GLU218 | |
| A | THR1277-GLY1284 | |
| A | ASN1341-VAL1392 | |
| A | ALA1415-LEU1431 | |
| A | GLU1535-GLU1545 | |
| A | LEU1595-THR1607 | |
| A | GLY1662-THR1683 | |
| A | ILE1707-GLY1736 | |
| A | ASN206-SER211 | |
| A | MET268-THR346 | |
| A | ARG372-TYR378 | |
| A | GLU764-ASN774 | |
| A | GLU829-GLY830 | |
| A | GLY884-ASP912 | |
| A | ASP934-ILE946 | |
| A | GLU1212-ILE1224 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30765606, ECO:0000269|PubMed:36696443, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J, ECO:0007744|PDB:8FHD |
| Chain | Residue | Details |
| B | ASN93 | |
| C | ARG135 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30190309, ECO:0000269|PubMed:30765606, ECO:0000269|PubMed:36696443, ECO:0007744|PDB:6AGF, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J, ECO:0007744|PDB:8FHD |
| Chain | Residue | Details |
| B | ASN110 | |
| B | ASN114 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30765606, ECO:0000269|PubMed:36696443, ECO:0000269|PubMed:36823201, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J, ECO:0007744|PDB:8FHD, ECO:0007744|PDB:8GZ1, ECO:0007744|PDB:8GZ2 |
| Chain | Residue | Details |
| B | ASN135 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL248-PHE267 | |
| C | ASN74 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 87 |
| Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE347-LEU371 | |
| A | PHE913-TRP933 | |
| A | GLY1393-ALA1414 | |
| A | PHE1684-PRO1706 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | MET379-ALA399 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE745-MET763 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL775-LYS794 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ASN809-VAL828 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU831-SER848 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ALA865-VAL883 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL947-LEU967 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE1194-PHE1211 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1225-LEU1243 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | TRP1258-ASN1276 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PRO1285-ARG1303 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1321-VAL1340 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | TYR1432-ILE1453 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE1517-VAL1534 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL1546-LEU1564 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | GLY1577-PHE1594 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU1608-VAL1624 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU1644-PHE1661 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1737-ILE1759 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 2 |
| Details | SITE: Is directly targeted by the spider protoxin-II => ECO:0000269|PubMed:30661758 |
| Chain | Residue | Details |
| A | GLU822 | |
| A | ASP827 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:25240195 |
| Chain | Residue | Details |
| A | SER1490 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN209 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30765606, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J |
| Chain | Residue | Details |
| A | ASN283 | |
| A | ASN1352 | |
| A | ASN1366 | |
| A | ASN1375 |
