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6J8G

Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (Y1755 up)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001518cellular_componentvoltage-gated sodium channel complex
A0005216molecular_functionmonoatomic ion channel activity
A0005248molecular_functionvoltage-gated sodium channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005272molecular_functionsodium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006814biological_processsodium ion transport
A0006954biological_processinflammatory response
A0007623biological_processcircadian rhythm
A0009636biological_processresponse to toxic substance
A0009791biological_processpost-embryonic development
A0016020cellular_componentmembrane
A0019228biological_processneuronal action potential
A0019233biological_processsensory perception of pain
A0030424cellular_componentaxon
A0033268cellular_componentnode of Ranvier
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0035725biological_processsodium ion transmembrane transport
A0042995cellular_componentcell projection
A0043679cellular_componentaxon terminus
A0048266biological_processbehavioral response to pain
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050974biological_processdetection of mechanical stimulus involved in sensory perception
A0055085biological_processtransmembrane transport
A0086002biological_processcardiac muscle cell action potential involved in contraction
A0098870biological_processaction potential propagation
B0001518cellular_componentvoltage-gated sodium channel complex
B0006814biological_processsodium ion transport
B0017080molecular_functionsodium channel regulator activity
C0016020cellular_componentmembrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues138
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:30190309
ChainResidueDetails
BGLY19-ILE157
AASP1458-ASN1514
ASER1568-VAL1576
ALYS1628-SER1640
ALEU1760-LYS1988
AALA173-ARG185
AILE228-SER241
AMET403-PHE745
AALA797-GLN805
ATRP849-ALA865
ALEU968-LYS1187
ALYS1251-THR1252
AGLU1305-ALA1317

site_idSWS_FT_FI2
Number of Residues21
DetailsTRANSMEM: Helical => ECO:0000305|PubMed:30190309, ECO:0007744|PDB:6AGF
ChainResidueDetails
BVAL158-ILE179

site_idSWS_FT_FI3
Number of Residues38
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:30190309
ChainResidueDetails
BTYR180-GLU218
AGLY1279-LYS1287
APHE1343-LEU1394
ALYS1406-LEU1431
AGLU1535-GLU1545
AILE1599-THR1607
ASER1664-ASN1686
ATRP1700-PRO1733
AVAL205-VAL210
AMET268-THR346
AGLU364-LYS376
AMET763-GLU771
ALEU823-LEU831
AGLY889-HIS915
AILE929-GLY940
AASP1213-ILE1224

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30765606, ECO:0000269|PubMed:36696443, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J, ECO:0007744|PDB:8FHD
ChainResidueDetails
BASN93
CARG135

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30190309, ECO:0000269|PubMed:30765606, ECO:0000269|PubMed:36696443, ECO:0007744|PDB:6AGF, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J, ECO:0007744|PDB:8FHD
ChainResidueDetails
BASN110
BASN114

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30765606, ECO:0000269|PubMed:36696443, ECO:0000269|PubMed:36823201, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J, ECO:0007744|PDB:8FHD, ECO:0007744|PDB:8GZ1, ECO:0007744|PDB:8GZ2
ChainResidueDetails
BASN135

site_idSWS_FT_FI7
Number of Residues25
DetailsTRANSMEM: Helical; Name=S5 of repeat I => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
AVAL242-PHE267
CASN74

site_idSWS_FT_FI8
Number of Residues50
DetailsINTRAMEM: Pore-forming => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
APHE347-TRP363
ASER916-TRP928
AGLY1395-PHE1405
ASER1687-GLY1699

site_idSWS_FT_FI9
Number of Residues25
DetailsTRANSMEM: Helical; Name=S6 of repeat I => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
ATHR377-ALA402

site_idSWS_FT_FI10
Number of Residues16
DetailsTRANSMEM: Helical; Name=S1 of repeat II => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
AVAL746-ALA762

site_idSWS_FT_FI11
Number of Residues24
DetailsTRANSMEM: Helical; Name=S2 of repeat II => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
APHE772-ILE796

site_idSWS_FT_FI12
Number of Residues16
DetailsTRANSMEM: Helical; Name=S3 of repeat II => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
AVAL806-GLU822

site_idSWS_FT_FI13
Number of Residues16
DetailsTRANSMEM: Helical; Name=S4 of repeat II => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
ASER832-SER848

site_idSWS_FT_FI14
Number of Residues22
DetailsTRANSMEM: Helical; Name=S5 of repeat II => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
ALEU866-PHE888

site_idSWS_FT_FI15
Number of Residues26
DetailsTRANSMEM: Helical; Name=S6 of repeat II => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
AGLN941-LEU967

site_idSWS_FT_FI16
Number of Residues24
DetailsTRANSMEM: Helical; Name=S1 of repeat III => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
AILE1188-GLU1212

site_idSWS_FT_FI17
Number of Residues25
DetailsTRANSMEM: Helical; Name=S2 of repeat III => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
AILE1225-TYR1250

site_idSWS_FT_FI18
Number of Residues25
DetailsTRANSMEM: Helical; Name=S3 of repeat III => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
ATYR1253-LEU1278

site_idSWS_FT_FI19
Number of Residues16
DetailsTRANSMEM: Helical; Name=S4 of repeat III => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
ASER1288-PHE1304

site_idSWS_FT_FI20
Number of Residues24
DetailsTRANSMEM: Helical; Name=S5 of repeat III => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
AILE1318-LEU1342

site_idSWS_FT_FI21
Number of Residues25
DetailsTRANSMEM: Helical; Name=S6 of repeat III => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
ATYR1432-ILE1457

site_idSWS_FT_FI22
Number of Residues19
DetailsTRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
AGLN1515-VAL1534

site_idSWS_FT_FI23
Number of Residues21
DetailsTRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
AVAL1546-ILE1567

site_idSWS_FT_FI24
Number of Residues21
DetailsTRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
AGLY1577-LEU1598

site_idSWS_FT_FI25
Number of Residues19
DetailsTRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
ALEU1608-ALA1627

site_idSWS_FT_FI26
Number of Residues22
DetailsTRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
ALEU1641-MET1663

site_idSWS_FT_FI27
Number of Residues25
DetailsTRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000305|PubMed:30765606, ECO:0007744|PDB:6J8I
ChainResidueDetails
ASER1734-ILE1759

site_idSWS_FT_FI28
Number of Residues2
DetailsSITE: Is directly targeted by the spider protoxin-II => ECO:0000269|PubMed:30661758
ChainResidueDetails
AGLU822
AASP827

site_idSWS_FT_FI29
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:25240195
ChainResidueDetails
ASER1490

site_idSWS_FT_FI30
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN209

site_idSWS_FT_FI31
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30765606, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J
ChainResidueDetails
AASN283
AASN1352
AASN1366
AASN1375

229183

PDB entries from 2024-12-18

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