6J74

Complex of GGTaseIII and full-length Ykt6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008318	molecular_function	protein prenyltransferase activity
A	0018342	biological_process	protein prenylation
B	0003824	molecular_function	catalytic activity
B	0004659	molecular_function	prenyltransferase activity
B	0004661	molecular_function	protein geranylgeranyltransferase activity
B	0004663	molecular_function	Rab geranylgeranyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0007601	biological_process	visual perception
B	0008270	molecular_function	zinc ion binding
B	0008318	molecular_function	protein prenyltransferase activity
B	0016740	molecular_function	transferase activity
B	0018344	biological_process	protein geranylgeranylation
B	0031267	molecular_function	small GTPase binding
B	0036211	biological_process	protein modification process
B	0046872	molecular_function	metal ion binding
C	0000139	cellular_component	Golgi membrane
C	0000421	cellular_component	autophagosome membrane
C	0005484	molecular_function	SNAP receptor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005768	cellular_component	endosome
C	0005783	cellular_component	endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006903	biological_process	vesicle targeting
C	0006904	biological_process	vesicle docking involved in exocytosis
C	0006906	biological_process	vesicle fusion
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0016192	biological_process	vesicle-mediated transport
C	0016740	molecular_function	transferase activity
C	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
C	0030133	cellular_component	transport vesicle
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0031201	cellular_component	SNARE complex
C	0031410	cellular_component	cytoplasmic vesicle
C	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
C	0042147	biological_process	retrograde transport, endosome to Golgi
C	0043025	cellular_component	neuronal cell body
C	0045296	molecular_function	cadherin binding
C	0097440	cellular_component	apical dendrite
C	0097441	cellular_component	basal dendrite

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PO4 A 401

Chain	Residue
A	LYS135
A	TYR191
B	LYS235
B	TYR241
B	ARG281
B	PO4401

---

site_id	AC2
Number of Residues	6
Details	binding site for residue PO4 B 401

Chain	Residue
B	HIS190
B	ARG232
B	TYR241
A	LYS135
A	TYR195
A	PO4401

---

site_id	AC3
Number of Residues	3
Details	binding site for residue ZN B 402

Chain	Residue
B	ASP238
B	CYS240
B	HIS290

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Repeat: {"description":"PFTA 1","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Repeat: {"description":"PFTA 2","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	39
Details	Repeat: {"description":"PFTA 3","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	39
Details	Repeat: {"description":"PFTA 4","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	Repeat: {"description":"PFTA 5","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	43
Details	Repeat: {"description":"PFTB 1","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	47
Details	Repeat: {"description":"PFTB 2","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	46
Details	Repeat: {"description":"PFTB 3","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	48
Details	Repeat: {"description":"PFTB 4","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	47
Details	Repeat: {"description":"PFTB 5","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	48
Details	Repeat: {"description":"PFTB 6","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q08603","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	118
Details	Domain: {"description":"Longin","evidences":[{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---