6J6X

Crystal structure of apo GGTaseIII

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008318	molecular_function	protein prenyltransferase activity
A	0018342	biological_process	protein prenylation
B	0003824	molecular_function	catalytic activity
B	0004659	molecular_function	prenyltransferase activity
B	0004661	molecular_function	protein geranylgeranyltransferase activity
B	0004663	molecular_function	Rab geranylgeranyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0007601	biological_process	visual perception
B	0008270	molecular_function	zinc ion binding
B	0008318	molecular_function	protein prenyltransferase activity
B	0016740	molecular_function	transferase activity
B	0018344	biological_process	protein geranylgeranylation
B	0031267	molecular_function	small GTPase binding
B	0036211	biological_process	protein modification process
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue MPD A 401

Chain	Residue
A	GLU7

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site_id	AC2
Number of Residues	3
Details	binding site for residue MG B 401

Chain	Residue
B	ASP109
B	GLU318
B	VAL319

---

site_id	AC3
Number of Residues	1
Details	binding site for residue MPD B 402

Chain	Residue
B	ARG46

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	39
Details	Repeat: {"description":"PFTA 3","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	43
Details	Repeat: {"description":"PFTB 1","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	47
Details	Repeat: {"description":"PFTB 2","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	46
Details	Repeat: {"description":"PFTB 3","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	48
Details	Repeat: {"description":"PFTB 4","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	48
Details	Repeat: {"description":"PFTB 6","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q08603","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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