6J4S

Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001938	biological_process	positive regulation of endothelial cell proliferation
A	0003779	molecular_function	actin binding
A	0004180	molecular_function	carboxypeptidase activity
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006508	biological_process	proteolysis
A	0008017	molecular_function	microtubule binding
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0045765	biological_process	regulation of angiogenesis
A	0045766	biological_process	positive regulation of angiogenesis
A	0061564	biological_process	axon development
A	0106423	molecular_function	tubulin-tyrosine carboxypeptidase
A	0140253	biological_process	cell-cell fusion
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0006508	biological_process	proteolysis
B	0008017	molecular_function	microtubule binding
B	0009306	biological_process	protein secretion
B	0010596	biological_process	negative regulation of endothelial cell migration
B	0016504	molecular_function	peptidase activator activity
B	0031397	biological_process	negative regulation of protein ubiquitination
B	0045177	cellular_component	apical part of cell
B	0061564	biological_process	axon development
B	1905048	biological_process	regulation of metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue GOL A 401

Chain	Residue
A	GLU176
A	HIS254
A	GLU255

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site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 402

Chain	Residue
A	TYR123
A	HIS125
A	SER210
A	ARG211
A	ALA213
A	HOH537

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site_id	AC3
Number of Residues	2
Details	binding site for residue GOL A 403

Chain	Residue
A	HIS241
A	HOH527

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site_id	AC4
Number of Residues	3
Details	binding site for residue PO4 A 404

Chain	Residue
A	LYS183
A	HIS192
A	LYS247

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"29146869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26794318","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"26794318","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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