6J44

Crystal structure of the redefined DNA-binding domain of human XPA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0006289	biological_process	nucleotide-excision repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	CYS105
A	CYS108
A	CYS126
A	CYS129

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Functional Information from PROSITE/UniProt

site_id	PS00752
Number of Residues	25
Details	XPA_1 XPA protein signature 1. CeECgkeFm.DsyLmnhFdlptCdnC

Chain	Residue	Details
A	CYS105-CYS129

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site_id	PS00753
Number of Residues	17
Details	XPA_2 XPA protein signature 2. LITKTEaKqEYLLkDcD

Chain	Residue	Details
A	LEU138-ASP154

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ZN_FING: ZN_FING => ECO:0000305|PubMed:2234061, ECO:0000305|PubMed:31253769

Chain	Residue	Details
A	CYS105-CYS129

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:31253769, ECO:0007744|PDB:1D4U, ECO:0007744|PDB:1XPA, ECO:0007744|PDB:6RO4

Chain	Residue	Details
A	CYS105
A	CYS108
A	CYS126
A	CYS129

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:16540648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER196

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447

Chain	Residue	Details
A	LYS145

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