6IZ3
Structural basis for activity of TRIC counter-ion channels in calcium release
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005267 | molecular_function | potassium channel activity |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0016020 | cellular_component | membrane |
A | 0042802 | molecular_function | identical protein binding |
A | 0051279 | biological_process | regulation of release of sequestered calcium ion into cytosol |
A | 0071805 | biological_process | potassium ion transmembrane transport |
B | 0005267 | molecular_function | potassium channel activity |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005789 | cellular_component | endoplasmic reticulum membrane |
B | 0016020 | cellular_component | membrane |
B | 0042802 | molecular_function | identical protein binding |
B | 0051279 | biological_process | regulation of release of sequestered calcium ion into cytosol |
B | 0071805 | biological_process | potassium ion transmembrane transport |
C | 0005267 | molecular_function | potassium channel activity |
C | 0005783 | cellular_component | endoplasmic reticulum |
C | 0005789 | cellular_component | endoplasmic reticulum membrane |
C | 0016020 | cellular_component | membrane |
C | 0042802 | molecular_function | identical protein binding |
C | 0051279 | biological_process | regulation of release of sequestered calcium ion into cytosol |
C | 0071805 | biological_process | potassium ion transmembrane transport |
D | 0005267 | molecular_function | potassium channel activity |
D | 0005783 | cellular_component | endoplasmic reticulum |
D | 0005789 | cellular_component | endoplasmic reticulum membrane |
D | 0016020 | cellular_component | membrane |
D | 0042802 | molecular_function | identical protein binding |
D | 0051279 | biological_process | regulation of release of sequestered calcium ion into cytosol |
D | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 192 |
Details | TOPO_DOM: Lumenal => ECO:0000305 |
Chain | Residue | Details |
A | MET1-SER15 | |
C | ALA69-THR79 | |
C | THR122-ALA139 | |
C | GLY197-ARG204 | |
D | MET1-SER15 | |
D | ALA69-THR79 | |
D | THR122-ALA139 | |
D | GLY197-ARG204 | |
A | ALA69-THR79 | |
A | THR122-ALA139 | |
A | GLY197-ARG204 | |
B | MET1-SER15 | |
B | ALA69-THR79 | |
B | THR122-ALA139 | |
B | GLY197-ARG204 | |
C | MET1-SER15 |
site_id | SWS_FT_FI2 |
Number of Residues | 64 |
Details | TRANSMEM: Helical;Name=1 => ECO:0000255 |
Chain | Residue | Details |
A | MET16-ALA32 | |
B | MET16-ALA32 | |
C | MET16-ALA32 | |
D | MET16-ALA32 |
site_id | SWS_FT_FI3 |
Number of Residues | 364 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
A | ARG33-HIS44 | |
C | PHE100-ASN102 | |
C | SER158-MET178 | |
C | HIS226-LYS284 | |
D | ARG33-HIS44 | |
D | PHE100-ASN102 | |
D | SER158-MET178 | |
D | HIS226-LYS284 | |
A | PHE100-ASN102 | |
A | SER158-MET178 | |
A | HIS226-LYS284 | |
B | ARG33-HIS44 | |
B | PHE100-ASN102 | |
B | SER158-MET178 | |
B | HIS226-LYS284 | |
C | ARG33-HIS44 |
site_id | SWS_FT_FI4 |
Number of Residues | 92 |
Details | TRANSMEM: Helical;Name=2 => ECO:0000255 |
Chain | Residue | Details |
A | SER45-LEU68 | |
B | SER45-LEU68 | |
C | SER45-LEU68 | |
D | SER45-LEU68 |
site_id | SWS_FT_FI5 |
Number of Residues | 76 |
Details | TRANSMEM: Helical;Name=3 => ECO:0000255 |
Chain | Residue | Details |
A | THR80-LEU99 | |
B | THR80-LEU99 | |
C | THR80-LEU99 | |
D | THR80-LEU99 |
site_id | SWS_FT_FI6 |
Number of Residues | 72 |
Details | TRANSMEM: Helical;Name=4 => ECO:0000255 |
Chain | Residue | Details |
A | CYS103-ARG121 | |
B | CYS103-ARG121 | |
C | CYS103-ARG121 | |
D | CYS103-ARG121 |
site_id | SWS_FT_FI7 |
Number of Residues | 68 |
Details | TRANSMEM: Helical;Name=5 => ECO:0000255 |
Chain | Residue | Details |
A | TRP140-ILE157 | |
B | TRP140-ILE157 | |
C | TRP140-ILE157 | |
D | TRP140-ILE157 |
site_id | SWS_FT_FI8 |
Number of Residues | 68 |
Details | TRANSMEM: Helical;Name=6 => ECO:0000255 |
Chain | Residue | Details |
A | SER179-HIS196 | |
B | SER179-HIS196 | |
C | SER179-HIS196 | |
D | SER179-HIS196 |
site_id | SWS_FT_FI9 |
Number of Residues | 80 |
Details | TRANSMEM: Helical;Name=7 => ECO:0000255 |
Chain | Residue | Details |
A | HIS205-THR225 | |
B | HIS205-THR225 | |
C | HIS205-THR225 | |
D | HIS205-THR225 |
site_id | SWS_FT_FI10 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9NA73 |
Chain | Residue | Details |
A | LYS117 | |
A | ARG121 | |
B | LYS117 | |
B | ARG121 | |
C | LYS117 | |
C | ARG121 | |
D | LYS117 | |
D | ARG121 |