Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6IUR

A phosphatase complex STRN3-PP2Aa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000159	cellular_component	protein phosphatase type 2A complex
A	0000775	cellular_component	chromosome, centromeric region
A	0000785	cellular_component	chromatin
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0007059	biological_process	chromosome segregation
A	0008287	cellular_component	protein serine/threonine phosphatase complex
A	0015630	cellular_component	microtubule cytoskeleton
A	0016020	cellular_component	membrane
A	0016180	biological_process	snRNA processing
A	0016328	cellular_component	lateral plasma membrane
A	0019888	molecular_function	protein phosphatase regulator activity
A	0030425	cellular_component	dendrite
A	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
A	0035330	biological_process	regulation of hippo signaling
A	0035331	biological_process	negative regulation of hippo signaling
A	0035556	biological_process	intracellular signal transduction
A	0040008	biological_process	regulation of growth
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043029	biological_process	T cell homeostasis
A	0045595	biological_process	regulation of cell differentiation
A	0046982	molecular_function	protein heterodimerization activity
A	0051225	biological_process	spindle assembly
A	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
A	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0065003	biological_process	protein-containing complex assembly
A	0070062	cellular_component	extracellular exosome
A	0090443	cellular_component	FAR/SIN/STRIPAK complex
A	0160232	cellular_component	INTAC complex
A	0160240	biological_process	RNA polymerase II transcription initiation surveillance
A	1990405	molecular_function	protein antigen binding
B	0000159	cellular_component	protein phosphatase type 2A complex
B	0000775	cellular_component	chromosome, centromeric region
B	0000785	cellular_component	chromatin
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0007059	biological_process	chromosome segregation
B	0008287	cellular_component	protein serine/threonine phosphatase complex
B	0015630	cellular_component	microtubule cytoskeleton
B	0016020	cellular_component	membrane
B	0016180	biological_process	snRNA processing
B	0016328	cellular_component	lateral plasma membrane
B	0019888	molecular_function	protein phosphatase regulator activity
B	0030425	cellular_component	dendrite
B	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
B	0035330	biological_process	regulation of hippo signaling
B	0035331	biological_process	negative regulation of hippo signaling
B	0035556	biological_process	intracellular signal transduction
B	0040008	biological_process	regulation of growth
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0043029	biological_process	T cell homeostasis
B	0045595	biological_process	regulation of cell differentiation
B	0046982	molecular_function	protein heterodimerization activity
B	0051225	biological_process	spindle assembly
B	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
B	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0065003	biological_process	protein-containing complex assembly
B	0070062	cellular_component	extracellular exosome
B	0090443	cellular_component	FAR/SIN/STRIPAK complex
B	0160232	cellular_component	INTAC complex
B	0160240	biological_process	RNA polymerase II transcription initiation surveillance
B	1990405	molecular_function	protein antigen binding
E	0000159	cellular_component	protein phosphatase type 2A complex
E	0000775	cellular_component	chromosome, centromeric region
E	0000785	cellular_component	chromatin
E	0004721	molecular_function	phosphoprotein phosphatase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0007059	biological_process	chromosome segregation
E	0008287	cellular_component	protein serine/threonine phosphatase complex
E	0015630	cellular_component	microtubule cytoskeleton
E	0016020	cellular_component	membrane
E	0016180	biological_process	snRNA processing
E	0016328	cellular_component	lateral plasma membrane
E	0019888	molecular_function	protein phosphatase regulator activity
E	0030425	cellular_component	dendrite
E	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
E	0035330	biological_process	regulation of hippo signaling
E	0035331	biological_process	negative regulation of hippo signaling
E	0035556	biological_process	intracellular signal transduction
E	0040008	biological_process	regulation of growth
E	0043005	cellular_component	neuron projection
E	0043025	cellular_component	neuronal cell body
E	0043029	biological_process	T cell homeostasis
E	0045595	biological_process	regulation of cell differentiation
E	0046982	molecular_function	protein heterodimerization activity
E	0051225	biological_process	spindle assembly
E	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
E	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E	0065003	biological_process	protein-containing complex assembly
E	0070062	cellular_component	extracellular exosome
E	0090443	cellular_component	FAR/SIN/STRIPAK complex
E	0160232	cellular_component	INTAC complex
E	0160240	biological_process	RNA polymerase II transcription initiation surveillance
E	1990405	molecular_function	protein antigen binding
F	0000159	cellular_component	protein phosphatase type 2A complex
F	0000775	cellular_component	chromosome, centromeric region
F	0000785	cellular_component	chromatin
F	0004721	molecular_function	phosphoprotein phosphatase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0007059	biological_process	chromosome segregation
F	0008287	cellular_component	protein serine/threonine phosphatase complex
F	0015630	cellular_component	microtubule cytoskeleton
F	0016020	cellular_component	membrane
F	0016180	biological_process	snRNA processing
F	0016328	cellular_component	lateral plasma membrane
F	0019888	molecular_function	protein phosphatase regulator activity
F	0030425	cellular_component	dendrite
F	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
F	0035330	biological_process	regulation of hippo signaling
F	0035331	biological_process	negative regulation of hippo signaling
F	0035556	biological_process	intracellular signal transduction
F	0040008	biological_process	regulation of growth
F	0043005	cellular_component	neuron projection
F	0043025	cellular_component	neuronal cell body
F	0043029	biological_process	T cell homeostasis
F	0045595	biological_process	regulation of cell differentiation
F	0046982	molecular_function	protein heterodimerization activity
F	0051225	biological_process	spindle assembly
F	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
F	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F	0065003	biological_process	protein-containing complex assembly
F	0070062	cellular_component	extracellular exosome
F	0090443	cellular_component	FAR/SIN/STRIPAK complex
F	0160232	cellular_component	INTAC complex
F	0160240	biological_process	RNA polymerase II transcription initiation surveillance
F	1990405	molecular_function	protein antigen binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue TME B 601

Chain	Residue
E	GLU23

site_id	AC2
Number of Residues	1
Details	binding site for residue TME C 201

Chain	Residue
C	LYS126

site_id	AC3
Number of Residues	4
Details	binding site for residue TME F 601

Chain	Residue
F	LEU55
F	ASP57
F	ILE59
F	SER95

site_id	AC4
Number of Residues	1
Details	binding site for residue TME F 602

Chain	Residue
F	TME603

site_id	AC5
Number of Residues	1
Details	binding site for residue TME F 603

Chain	Residue
F	TME602

site_id	AC6
Number of Residues	1
Details	binding site for residue TME F 604

Chain	Residue
F	GLU64

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	152
Details	Repeat: {"description":"HEAT 1","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	148
Details	Repeat: {"description":"HEAT 2","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	152
Details	Repeat: {"description":"HEAT 3","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	148
Details	Repeat: {"description":"HEAT 4","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	152
Details	Repeat: {"description":"HEAT 5","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	152
Details	Repeat: {"description":"HEAT 6","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	152
Details	Repeat: {"description":"HEAT 7","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	168
Details	Repeat: {"description":"HEAT 8","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	152
Details	Repeat: {"description":"HEAT 9","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	152
Details	Repeat: {"description":"HEAT 10","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	152
Details	Repeat: {"description":"HEAT 11","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	152
Details	Repeat: {"description":"HEAT 12","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	152
Details	Repeat: {"description":"HEAT 13","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	152
Details	Repeat: {"description":"HEAT 14","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1564
Details	Region: {"description":"PP2A subunit B binding"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1096
Details	Region: {"description":"Polyoma small and medium T antigens Binding"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	616
Details	Region: {"description":"SV40 small T antigen binding"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)