6ITE

Crystal structure of group A Streptococcal surface dehydrogenase (SDH)

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0000166	molecular_function	nucleotide binding
O	0002020	molecular_function	protease binding
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0005737	cellular_component	cytoplasm
O	0006006	biological_process	glucose metabolic process
O	0006096	biological_process	glycolytic process
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
P	0000166	molecular_function	nucleotide binding
P	0002020	molecular_function	protease binding
P	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P	0005737	cellular_component	cytoplasm
P	0006006	biological_process	glucose metabolic process
P	0006096	biological_process	glycolytic process
P	0016491	molecular_function	oxidoreductase activity
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0050661	molecular_function	NADP binding
P	0051287	molecular_function	NAD binding
Q	0000166	molecular_function	nucleotide binding
Q	0002020	molecular_function	protease binding
Q	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Q	0005737	cellular_component	cytoplasm
Q	0006006	biological_process	glucose metabolic process
Q	0006096	biological_process	glycolytic process
Q	0016491	molecular_function	oxidoreductase activity
Q	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Q	0050661	molecular_function	NADP binding
Q	0051287	molecular_function	NAD binding
R	0000166	molecular_function	nucleotide binding
R	0002020	molecular_function	protease binding
R	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
R	0005737	cellular_component	cytoplasm
R	0006006	biological_process	glucose metabolic process
R	0006096	biological_process	glycolytic process
R	0016491	molecular_function	oxidoreductase activity
R	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
R	0050661	molecular_function	NADP binding
R	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	35
Details	binding site for residue NAD P 401

Chain	Residue
P	ASN8
P	ALA96
P	THR97
P	GLY98
P	PHE99
P	PHE100
P	THR121
P	ALA122
P	ASN316
P	TYR320
P	SO4402
P	GLY9
P	HOH520
P	HOH535
P	HOH549
P	HOH567
P	HOH581
P	HOH583
P	HOH587
P	HOH604
P	HOH625
P	HOH656
P	GLY11
P	HOH658
P	HOH663
P	HOH681
P	HOH724
Q	PRO191
Q	HOH560
P	ARG12
P	ILE13
P	ASN33
P	ASP34
P	LEU35
P	ARG78

---

site_id	AC2
Number of Residues	9
Details	binding site for residue SO4 P 402

Chain	Residue
P	THR182
P	ASP184
P	ARG199
P	ARG235
P	NAD401
P	HOH535
P	HOH658
P	HOH661
P	HOH694

---

site_id	AC3
Number of Residues	36
Details	binding site for residue NAD Q 401

Chain	Residue
P	PRO191
P	HOH559
Q	ASN8
Q	GLY9
Q	GLY11
Q	ARG12
Q	ILE13
Q	ASN33
Q	ASP34
Q	LEU35
Q	GLU77
Q	ARG78
Q	ALA96
Q	THR97
Q	GLY98
Q	PHE99
Q	PHE100
Q	THR121
Q	ALA122
Q	ASN316
Q	TYR320
Q	SO4402
Q	HOH516
Q	HOH540
Q	HOH564
Q	HOH566
Q	HOH577
Q	HOH587
Q	HOH591
Q	HOH596
Q	HOH601
Q	HOH621
Q	HOH641
Q	HOH646
Q	HOH651
Q	HOH702

---

site_id	AC4
Number of Residues	10
Details	binding site for residue SO4 Q 402

Chain	Residue
Q	THR182
Q	ASP184
Q	ARG199
Q	ARG235
Q	NAD401
Q	HOH566
Q	HOH580
Q	HOH628
Q	HOH636
Q	HOH641

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 Q 403

Chain	Residue
Q	LYS172
Q	HOH505
Q	HOH530
Q	HOH538
R	LYS172

---

site_id	AC6
Number of Residues	33
Details	binding site for residue NAD R 401

Chain	Residue
R	GLY11
R	ARG12
R	ILE13
R	ASN33
R	ASP34
R	LEU35
R	GLU77
R	ARG78
R	ALA96
R	THR97
R	GLY98
R	PHE99
R	PHE100
R	THR121
R	ALA122
R	ASN316
R	TYR320
R	SO4402
R	HOH514
R	HOH518
R	HOH526
R	HOH531
R	HOH546
R	HOH568
R	HOH588
R	HOH600
R	HOH622
R	HOH629
R	HOH642
O	PRO191
O	HOH535
R	ASN8
R	GLY9

---

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 R 402

Chain	Residue
R	THR182
R	ARG199
R	ARG235
R	NAD401
R	HOH517
R	HOH591

---

site_id	AC8
Number of Residues	35
Details	binding site for residue NAD O 401

Chain	Residue
O	ASN8
O	GLY9
O	GLY11
O	ARG12
O	ILE13
O	ASN33
O	ASP34
O	LEU35
O	GLU77
O	ARG78
O	ALA96
O	THR97
O	GLY98
O	PHE99
O	PHE100
O	THR121
O	ALA122
O	ASN316
O	TYR320
O	SO4402
O	HOH514
O	HOH537
O	HOH546
O	HOH558
O	HOH562
O	HOH572
O	HOH590
O	HOH597
O	HOH617
O	HOH638
O	HOH645
O	HOH646
O	HOH677
R	PRO191
R	HOH569

---

site_id	AC9
Number of Residues	8
Details	binding site for residue SO4 O 402

Chain	Residue
O	THR182
O	ASP184
O	ARG199
O	ARG235
O	NAD401
O	HOH514
O	HOH601
O	HOH628

---

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 O 403

Chain	Residue
O	LYS172
O	HOH505
O	HOH534
O	HOH568
P	LYS172

---

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
P	ALA150-LEU157

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P00362","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00362","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Activates thiol group during catalysis","evidences":[{"source":"UniProtKB","id":"Q6GIL8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---