6IRY

Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016422	molecular_function	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
A	0099122	molecular_function	RNA polymerase II C-terminal domain binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue SAH A 701

Chain	Residue
A	GLN495
A	CYS529
A	SER530
A	PRO544
A	PHE545
A	GLU556
A	ASN558
A	PRO560
A	HOH819
A	HOH856
A	HOH898
A	LEU498
A	HOH964
A	PHE503
A	GLU515
A	CYS516
A	PHE517
A	ALA518
A	SER519
A	ASN522

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site_id	AC2
Number of Residues	8
Details	binding site for residue EDO A 702

Chain	Residue
A	LEU241
A	LYS245
A	PRO253
A	LEU254
A	ALA531
A	PHE532
A	HOH819
A	HOH831

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site_id	AC3
Number of Residues	8
Details	binding site for residue EDO A 703

Chain	Residue
A	PRO201
A	HIS202
A	PRO203
A	PRO419
A	PRO420
A	LYS468
A	SER471
A	HOH915

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:30467178, ECO:0007744|PDB:6IRZ, ECO:0007744|PDB:6IS0

Chain	Residue	Details
A	ARG239
A	ARG269
A	GLU563
A	TRP593

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:30467178, ECO:0007744|PDB:6IRY, ECO:0007744|PDB:6IRZ, ECO:0007744|PDB:6IS0

Chain	Residue	Details
A	ASN558
A	PHE619

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