6IRG

Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1400
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ

Chain	Residue	Details
B	PRO23-SER557
B	ALA647-ILE814
D	PRO23-SER557
D	ALA647-ILE814

---

site_id	SWS_FT_FI2
Number of Residues	118
Details	TRANSMEM: Helical => ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ

Chain	Residue	Details
B	VAL558-PHE577
B	THR626-THR646
B	ASP815-PHE835
D	VAL558-PHE577
D	THR626-THR646
D	ASP815-PHE835

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ

Chain	Residue	Details
B	GLU578-THR600
B	SER616-THR625
D	GLU578-THR600
D	SER616-THR625

---

site_id	SWS_FT_FI4
Number of Residues	28
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:34186027

Chain	Residue	Details
B	ILE601-ASN615
D	ILE601-ASN615

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q00959

Chain	Residue	Details
B	HIS44
B	HIS128
B	GLU266
B	ASP282
D	HIS44
D	HIS128
D	GLU266
D	ASP282

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA

Chain	Residue	Details
B	SER511
D	THR690
B	THR513
B	ARG518
B	SER689
B	THR690
D	SER511
D	THR513
D	ARG518
D	SER689

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9

Chain	Residue	Details
B	ASP731
D	ASP731

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	SITE: Functional determinant of NMDA receptors => ECO:0000250

Chain	Residue	Details
B	ASN614
D	ASN614

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN75
D	ASN542
B	ASN380
B	ASN443
B	ASN444
B	ASN542
D	ASN75
D	ASN380
D	ASN443
D	ASN444

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOS

Chain	Residue	Details
B	ASN340
D	ASN340

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ, ECO:0007744|PDB:7EOR, ECO:0007744|PDB:7EOT, ECO:0007744|PDB:7EOU

Chain	Residue	Details
B	ASN687
D	ASN687

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97, ECO:0007744|PDB:7EOQ

Chain	Residue	Details
C	ASN276
A	ASN276

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN300
C	ASN440
C	ASN491
C	ASN674
A	ASN300
A	ASN440
A	ASN491
A	ASN674

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97

Chain	Residue	Details
C	ASN350
A	ASN350

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97

Chain	Residue	Details
C	ASN368
A	ASN368

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0007744|PDB:7EOQ, ECO:0007744|PDB:7YFR

Chain	Residue	Details
C	ASN471
A	ASN471

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0000312|PDB:8E99, ECO:0007744|PDB:7EOQ

Chain	Residue	Details
C	ASN771
A	ASN771

---