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6IOK

Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state)

Functional Information from GO Data
ChainGOidnamespacecontents
A0009279cellular_componentcell outer membrane
A0015562molecular_functionefflux transmembrane transporter activity
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0046677biological_processresponse to antibiotic
A0055085biological_processtransmembrane transport
B0009279cellular_componentcell outer membrane
B0015562molecular_functionefflux transmembrane transporter activity
B0016020cellular_componentmembrane
B0022857molecular_functiontransmembrane transporter activity
B0046677biological_processresponse to antibiotic
B0055085biological_processtransmembrane transport
C0009279cellular_componentcell outer membrane
C0015562molecular_functionefflux transmembrane transporter activity
C0016020cellular_componentmembrane
C0022857molecular_functiontransmembrane transporter activity
C0046677biological_processresponse to antibiotic
C0055085biological_processtransmembrane transport
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0015562molecular_functionefflux transmembrane transporter activity
E0016020cellular_componentmembrane
E0022857molecular_functiontransmembrane transporter activity
E0042908biological_processxenobiotic transport
E0042910molecular_functionxenobiotic transmembrane transporter activity
E0046677biological_processresponse to antibiotic
E0055085biological_processtransmembrane transport
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0015562molecular_functionefflux transmembrane transporter activity
F0016020cellular_componentmembrane
F0022857molecular_functiontransmembrane transporter activity
F0042908biological_processxenobiotic transport
F0042910molecular_functionxenobiotic transmembrane transporter activity
F0046677biological_processresponse to antibiotic
F0055085biological_processtransmembrane transport
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0015562molecular_functionefflux transmembrane transporter activity
G0016020cellular_componentmembrane
G0022857molecular_functiontransmembrane transporter activity
G0042908biological_processxenobiotic transport
G0042910molecular_functionxenobiotic transmembrane transporter activity
G0046677biological_processresponse to antibiotic
G0055085biological_processtransmembrane transport
I0005886cellular_componentplasma membrane
I0015562molecular_functionefflux transmembrane transporter activity
I0016020cellular_componentmembrane
I0022857molecular_functiontransmembrane transporter activity
I0042802molecular_functionidentical protein binding
I0046677biological_processresponse to antibiotic
I0051260biological_processprotein homooligomerization
I0055085biological_processtransmembrane transport
J0005886cellular_componentplasma membrane
J0015562molecular_functionefflux transmembrane transporter activity
J0016020cellular_componentmembrane
J0022857molecular_functiontransmembrane transporter activity
J0042802molecular_functionidentical protein binding
J0046677biological_processresponse to antibiotic
J0051260biological_processprotein homooligomerization
J0055085biological_processtransmembrane transport
K0005886cellular_componentplasma membrane
K0015562molecular_functionefflux transmembrane transporter activity
K0016020cellular_componentmembrane
K0022857molecular_functiontransmembrane transporter activity
K0042802molecular_functionidentical protein binding
K0046677biological_processresponse to antibiotic
K0051260biological_processprotein homooligomerization
K0055085biological_processtransmembrane transport
L0005886cellular_componentplasma membrane
L0015562molecular_functionefflux transmembrane transporter activity
L0016020cellular_componentmembrane
L0022857molecular_functiontransmembrane transporter activity
L0042802molecular_functionidentical protein binding
L0046677biological_processresponse to antibiotic
L0051260biological_processprotein homooligomerization
L0055085biological_processtransmembrane transport
M0005886cellular_componentplasma membrane
M0015562molecular_functionefflux transmembrane transporter activity
M0016020cellular_componentmembrane
M0022857molecular_functiontransmembrane transporter activity
M0042802molecular_functionidentical protein binding
M0046677biological_processresponse to antibiotic
M0051260biological_processprotein homooligomerization
M0055085biological_processtransmembrane transport
N0005886cellular_componentplasma membrane
N0015562molecular_functionefflux transmembrane transporter activity
N0016020cellular_componentmembrane
N0022857molecular_functiontransmembrane transporter activity
N0042802molecular_functionidentical protein binding
N0046677biological_processresponse to antibiotic
N0051260biological_processprotein homooligomerization
N0055085biological_processtransmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues390
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10187844
ChainResidueDetails
FMET1-PRO9
GGLU414-ALA441
GLEU497-ARG538
GGLU892-PRO897
GGLU946-PRO972
GSER1028-GLN1046
EMET1-PRO9
EGLN360-THR365
EGLU414-ALA441
ELEU497-ARG538
EGLU892-PRO897
FGLN360-THR365
EGLU946-PRO972
ESER1028-GLN1046
FGLU414-ALA441
FLEU497-ARG538
FGLU892-PRO897
FGLU946-PRO972
FSER1028-GLN1046
GMET1-PRO9
GGLN360-THR365

site_idSWS_FT_FI2
Number of Residues702
DetailsTRANSMEM: Helical
ChainResidueDetails
FILE10-LEU28
FVAL924-VAL945
FILE973-THR991
FVAL1005-VAL1027
GILE10-LEU28
GVAL340-LEU359
GLEU366-ALA385
GTHR392-VAL413
GLEU442-GLY460
GILE474-MET496
GALA539-THR557
FVAL340-LEU359
GALA872-TYR891
GPHE898-MET917
GVAL924-VAL945
GILE973-THR991
GVAL1005-VAL1027
EILE10-LEU28
EVAL340-LEU359
ELEU366-ALA385
ETHR392-VAL413
ELEU442-GLY460
FLEU366-ALA385
EILE474-MET496
EALA539-THR557
EALA872-TYR891
EPHE898-MET917
EVAL924-VAL945
EILE973-THR991
EVAL1005-VAL1027
FTHR392-VAL413
FLEU442-GLY460
FILE474-MET496
FALA539-THR557
FALA872-TYR891
FPHE898-MET917

site_idSWS_FT_FI3
Number of Residues1971
DetailsTOPO_DOM: Periplasmic => ECO:0000269|PubMed:10187844
ChainResidueDetails
FSER29-GLU339
GARG558-GLN871
GARG918-ASP923
GGLY992-GLY1004
ESER29-GLU339
EPHE386-ASN391
EGLY461-THR473
EARG558-GLN871
EARG918-ASP923
EGLY992-GLY1004
FPHE386-ASN391
FGLY461-THR473
FARG558-GLN871
FARG918-ASP923
FGLY992-GLY1004
GSER29-GLU339
GPHE386-ASN391
GGLY461-THR473

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PDB entries from 2024-11-06

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