Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6IO4

Silver-bound Glyceraldehyde-3-phosphate dehydrogenase A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006096	biological_process	glycolytic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0042802	molecular_function	identical protein binding
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0000166	molecular_function	nucleotide binding
B	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006096	biological_process	glycolytic process
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0042802	molecular_function	identical protein binding
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
C	0000166	molecular_function	nucleotide binding
C	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006096	biological_process	glycolytic process
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0042802	molecular_function	identical protein binding
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
D	0000166	molecular_function	nucleotide binding
D	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0006096	biological_process	glycolytic process
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0042802	molecular_function	identical protein binding
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding
E	0000166	molecular_function	nucleotide binding
E	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006006	biological_process	glucose metabolic process
E	0006096	biological_process	glycolytic process
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0042802	molecular_function	identical protein binding
E	0050661	molecular_function	NADP binding
E	0051287	molecular_function	NAD binding
F	0000166	molecular_function	nucleotide binding
F	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006006	biological_process	glucose metabolic process
F	0006096	biological_process	glycolytic process
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0042802	molecular_function	identical protein binding
F	0050661	molecular_function	NADP binding
F	0051287	molecular_function	NAD binding
G	0000166	molecular_function	nucleotide binding
G	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006006	biological_process	glucose metabolic process
G	0006096	biological_process	glycolytic process
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0042802	molecular_function	identical protein binding
G	0050661	molecular_function	NADP binding
G	0051287	molecular_function	NAD binding
H	0000166	molecular_function	nucleotide binding
H	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006006	biological_process	glucose metabolic process
H	0006096	biological_process	glycolytic process
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0042802	molecular_function	identical protein binding
H	0050661	molecular_function	NADP binding
H	0051287	molecular_function	NAD binding
I	0000166	molecular_function	nucleotide binding
I	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006006	biological_process	glucose metabolic process
I	0006096	biological_process	glycolytic process
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
I	0042802	molecular_function	identical protein binding
I	0050661	molecular_function	NADP binding
I	0051287	molecular_function	NAD binding
J	0000166	molecular_function	nucleotide binding
J	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006006	biological_process	glucose metabolic process
J	0006096	biological_process	glycolytic process
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
J	0042802	molecular_function	identical protein binding
J	0050661	molecular_function	NADP binding
J	0051287	molecular_function	NAD binding
K	0000166	molecular_function	nucleotide binding
K	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006006	biological_process	glucose metabolic process
K	0006096	biological_process	glycolytic process
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
K	0042802	molecular_function	identical protein binding
K	0050661	molecular_function	NADP binding
K	0051287	molecular_function	NAD binding
L	0000166	molecular_function	nucleotide binding
L	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006006	biological_process	glucose metabolic process
L	0006096	biological_process	glycolytic process
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
L	0042802	molecular_function	identical protein binding
L	0050661	molecular_function	NADP binding
L	0051287	molecular_function	NAD binding
M	0000166	molecular_function	nucleotide binding
M	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006006	biological_process	glucose metabolic process
M	0006096	biological_process	glycolytic process
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
M	0042802	molecular_function	identical protein binding
M	0050661	molecular_function	NADP binding
M	0051287	molecular_function	NAD binding
N	0000166	molecular_function	nucleotide binding
N	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006006	biological_process	glucose metabolic process
N	0006096	biological_process	glycolytic process
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
N	0042802	molecular_function	identical protein binding
N	0050661	molecular_function	NADP binding
N	0051287	molecular_function	NAD binding
O	0000166	molecular_function	nucleotide binding
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006006	biological_process	glucose metabolic process
O	0006096	biological_process	glycolytic process
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0042802	molecular_function	identical protein binding
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
P	0000166	molecular_function	nucleotide binding
P	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006006	biological_process	glucose metabolic process
P	0006096	biological_process	glycolytic process
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0042802	molecular_function	identical protein binding
P	0050661	molecular_function	NADP binding
P	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue AG A 401

Chain	Residue
A	CYS149
A	THR150
A	HIS176
A	ASN313

site_id	AC2
Number of Residues	4
Details	binding site for residue AG B 401

Chain	Residue
B	CYS149
B	THR150
B	HIS176
B	ASN313

site_id	AC3
Number of Residues	3
Details	binding site for residue AG C 401

Chain	Residue
C	THR150
C	HIS176
C	CYS149

site_id	AC4
Number of Residues	4
Details	binding site for residue AG D 401

Chain	Residue
D	CYS149
D	THR150
D	HIS176
D	ASN313

site_id	AC5
Number of Residues	3
Details	binding site for residue AG E 401

Chain	Residue
E	CYS149
E	THR150
E	HIS176

site_id	AC6
Number of Residues	4
Details	binding site for residue AG F 401

Chain	Residue
F	CYS149
F	THR150
F	HIS176
F	ASN313

site_id	AC7
Number of Residues	3
Details	binding site for residue AG G 401

Chain	Residue
G	CYS149
G	THR150
G	HIS176

site_id	AC8
Number of Residues	4
Details	binding site for residue AG H 401

Chain	Residue
H	CYS149
H	THR150
H	HIS176
H	ASN313

site_id	AC9
Number of Residues	3
Details	binding site for residue AG I 401

Chain	Residue
I	CYS149
I	THR150
I	HIS176

site_id	AD1
Number of Residues	4
Details	binding site for residue AG J 401

Chain	Residue
J	CYS149
J	THR150
J	HIS176
J	ASN313

site_id	AD2
Number of Residues	4
Details	binding site for residue AG K 401

Chain	Residue
K	CYS149
K	THR150
K	HIS176
K	TYR311

site_id	AD3
Number of Residues	4
Details	binding site for residue AG L 401

Chain	Residue
L	CYS149
L	THR150
L	HIS176
L	ASN313

site_id	AD4
Number of Residues	3
Details	binding site for residue AG M 401

Chain	Residue
M	CYS149
M	THR150
M	HIS176

site_id	AD5
Number of Residues	4
Details	binding site for residue AG N 401

Chain	Residue
N	CYS149
N	THR150
N	HIS176
N	TYR311

site_id	AD6
Number of Residues	4
Details	binding site for residue AG O 401

Chain	Residue
O	CYS149
O	THR150
O	HIS176
O	ASN313

site_id	AD7
Number of Residues	4
Details	binding site for residue AG P 401

Chain	Residue
P	CYS149
P	THR150
P	HIS176
P	ASN313

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
A	ALA147-LEU154

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: Nucleophile => ECO:0000305\|PubMed:10978154

Chain	Residue	Details
A	CYS149
J	CYS149
K	CYS149
L	CYS149
M	CYS149
N	CYS149
O	CYS149
P	CYS149
B	CYS149
C	CYS149
D	CYS149
E	CYS149
F	CYS149
G	CYS149
H	CYS149
I	CYS149

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:10978154, ECO:0000269\|PubMed:19542219, ECO:0000269\|PubMed:8636984, ECO:0000269\|Ref.18

Chain	Residue	Details
A	ARG10
J	ARG10
K	ARG10
L	ARG10
M	ARG10
N	ARG10
O	ARG10
P	ARG10
B	ARG10
C	ARG10
D	ARG10
E	ARG10
F	ARG10
G	ARG10
H	ARG10
I	ARG10

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:10978154, ECO:0000269\|PubMed:19542219, ECO:0000269\|PubMed:8636984

Chain	Residue	Details
A	ASP32
E	ASN313
F	ASP32
F	ASN313
G	ASP32
G	ASN313
H	ASP32
H	ASN313
I	ASP32
I	ASN313
J	ASP32
A	ASN313
J	ASN313
K	ASP32
K	ASN313
L	ASP32
L	ASN313
M	ASP32
M	ASN313
N	ASP32
N	ASN313
O	ASP32
B	ASP32
O	ASN313
P	ASP32
P	ASN313
B	ASN313
C	ASP32
C	ASN313
D	ASP32
D	ASN313
E	ASP32

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:10978154, ECO:0000269\|PubMed:19542219

Chain	Residue	Details
A	ARG77
J	ARG77
K	ARG77
L	ARG77
M	ARG77
N	ARG77
O	ARG77
P	ARG77
B	ARG77
C	ARG77
D	ARG77
E	ARG77
F	ARG77
G	ARG77
H	ARG77
I	ARG77

site_id	SWS_FT_FI5
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:19542219

Chain	Residue	Details
A	THR119
J	THR119
K	THR119
L	THR119
M	THR119
N	THR119
O	THR119
P	THR119
B	THR119
C	THR119
D	THR119
E	THR119
F	THR119
G	THR119
H	THR119
I	THR119

site_id	SWS_FT_FI6
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:10978154

Chain	Residue	Details
A	SER148
E	THR208
F	SER148
F	THR208
G	SER148
G	THR208
H	SER148
H	THR208
I	SER148
I	THR208
J	SER148
A	THR208
J	THR208
K	SER148
K	THR208
L	SER148
L	THR208
M	SER148
M	THR208
N	SER148
N	THR208
O	SER148
B	SER148
O	THR208
P	SER148
P	THR208
B	THR208
C	SER148
C	THR208
D	SER148
D	THR208
E	SER148

site_id	SWS_FT_FI7
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00362

Chain	Residue	Details
A	THR179
J	THR179
K	THR179
L	THR179
M	THR179
N	THR179
O	THR179
P	THR179
B	THR179
C	THR179
D	THR179
E	THR179
F	THR179
G	THR179
H	THR179
I	THR179

site_id	SWS_FT_FI8
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:19542219, ECO:0000269\|Ref.18, ECO:0000305\|PubMed:10978154

Chain	Residue	Details
A	ARG231
J	ARG231
K	ARG231
L	ARG231
M	ARG231
N	ARG231
O	ARG231
P	ARG231
B	ARG231
C	ARG231
D	ARG231
E	ARG231
F	ARG231
G	ARG231
H	ARG231
I	ARG231

site_id	SWS_FT_FI9
Number of Residues	16
Details	SITE: Activates thiol group during catalysis => ECO:0000269\|PubMed:2659073

Chain	Residue	Details
A	HIS176
J	HIS176
K	HIS176
L	HIS176
M	HIS176
N	HIS176
O	HIS176
P	HIS176
B	HIS176
C	HIS176
D	HIS176
E	HIS176
F	HIS176
G	HIS176
H	HIS176
I	HIS176

site_id	SWS_FT_FI10
Number of Residues	128
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
A	LYS114
B	LYS123
M	LYS216
M	LYS224
M	LYS248
M	LYS256
M	LYS260
N	LYS114
N	LYS123
N	LYS212
N	LYS216
N	LYS224
B	LYS212
N	LYS248
N	LYS256
N	LYS260
O	LYS114
O	LYS123
O	LYS212
O	LYS216
O	LYS224
O	LYS248
O	LYS256
B	LYS216
O	LYS260
P	LYS114
P	LYS123
P	LYS212
P	LYS216
P	LYS224
P	LYS248
P	LYS256
P	LYS260
B	LYS224
B	LYS248
B	LYS256
B	LYS260
C	LYS114
C	LYS123
C	LYS212
A	LYS123
C	LYS216
C	LYS224
C	LYS248
C	LYS256
C	LYS260
D	LYS114
D	LYS123
D	LYS212
D	LYS216
D	LYS224
A	LYS212
D	LYS248
D	LYS256
D	LYS260
E	LYS114
E	LYS123
E	LYS212
E	LYS216
E	LYS224
E	LYS248
E	LYS256
A	LYS216
E	LYS260
F	LYS114
F	LYS123
F	LYS212
F	LYS216
F	LYS224
F	LYS248
F	LYS256
F	LYS260
G	LYS114
A	LYS224
G	LYS123
G	LYS212
G	LYS216
G	LYS224
G	LYS248
G	LYS256
G	LYS260
H	LYS114
H	LYS123
H	LYS212
A	LYS248
H	LYS216
H	LYS224
H	LYS248
H	LYS256
H	LYS260
I	LYS114
I	LYS123
I	LYS212
I	LYS216
I	LYS224
A	LYS256
I	LYS248
I	LYS256
I	LYS260
J	LYS114
J	LYS123
J	LYS212
J	LYS216
J	LYS224
J	LYS248
J	LYS256
A	LYS260
J	LYS260
K	LYS114
K	LYS123
K	LYS212
K	LYS216
K	LYS224
K	LYS248
K	LYS256
K	LYS260
L	LYS114
B	LYS114
L	LYS123
L	LYS212
L	LYS216
L	LYS224
L	LYS248
L	LYS256
L	LYS260
M	LYS114
M	LYS123
M	LYS212

site_id	SWS_FT_FI11
Number of Residues	48
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
A	LYS131
D	LYS131
D	LYS191
D	LYS330
E	LYS131
E	LYS191
E	LYS330
F	LYS131
F	LYS191
F	LYS330
G	LYS131
A	LYS191
G	LYS191
G	LYS330
H	LYS131
H	LYS191
H	LYS330
I	LYS131
I	LYS191
I	LYS330
J	LYS131
J	LYS191
A	LYS330
J	LYS330
K	LYS131
K	LYS191
K	LYS330
L	LYS131
L	LYS191
L	LYS330
M	LYS131
M	LYS191
M	LYS330
B	LYS131
N	LYS131
N	LYS191
N	LYS330
O	LYS131
O	LYS191
O	LYS330
P	LYS131
P	LYS191
P	LYS330
B	LYS191
B	LYS330
C	LYS131
C	LYS191
C	LYS330

site_id	SWS_FT_FI12
Number of Residues	16
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:18723842

Chain	Residue	Details
A	LYS137
J	LYS137
K	LYS137
L	LYS137
M	LYS137
N	LYS137
O	LYS137
P	LYS137
B	LYS137
C	LYS137
D	LYS137
E	LYS137
F	LYS137
G	LYS137
H	LYS137
I	LYS137

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)