6IO4

Silver-bound Glyceraldehyde-3-phosphate dehydrogenase A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006096	biological_process	glycolytic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0042802	molecular_function	identical protein binding
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
A	0072524	biological_process	pyridine-containing compound metabolic process
B	0000166	molecular_function	nucleotide binding
B	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006096	biological_process	glycolytic process
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0042802	molecular_function	identical protein binding
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
B	0072524	biological_process	pyridine-containing compound metabolic process
C	0000166	molecular_function	nucleotide binding
C	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006096	biological_process	glycolytic process
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0042802	molecular_function	identical protein binding
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
C	0072524	biological_process	pyridine-containing compound metabolic process
D	0000166	molecular_function	nucleotide binding
D	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0006096	biological_process	glycolytic process
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0042802	molecular_function	identical protein binding
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding
D	0072524	biological_process	pyridine-containing compound metabolic process
E	0000166	molecular_function	nucleotide binding
E	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006006	biological_process	glucose metabolic process
E	0006096	biological_process	glycolytic process
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0042802	molecular_function	identical protein binding
E	0050661	molecular_function	NADP binding
E	0051287	molecular_function	NAD binding
E	0072524	biological_process	pyridine-containing compound metabolic process
F	0000166	molecular_function	nucleotide binding
F	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006006	biological_process	glucose metabolic process
F	0006096	biological_process	glycolytic process
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0042802	molecular_function	identical protein binding
F	0050661	molecular_function	NADP binding
F	0051287	molecular_function	NAD binding
F	0072524	biological_process	pyridine-containing compound metabolic process
G	0000166	molecular_function	nucleotide binding
G	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006006	biological_process	glucose metabolic process
G	0006096	biological_process	glycolytic process
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0042802	molecular_function	identical protein binding
G	0050661	molecular_function	NADP binding
G	0051287	molecular_function	NAD binding
G	0072524	biological_process	pyridine-containing compound metabolic process
H	0000166	molecular_function	nucleotide binding
H	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006006	biological_process	glucose metabolic process
H	0006096	biological_process	glycolytic process
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0042802	molecular_function	identical protein binding
H	0050661	molecular_function	NADP binding
H	0051287	molecular_function	NAD binding
H	0072524	biological_process	pyridine-containing compound metabolic process
I	0000166	molecular_function	nucleotide binding
I	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006006	biological_process	glucose metabolic process
I	0006096	biological_process	glycolytic process
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
I	0042802	molecular_function	identical protein binding
I	0050661	molecular_function	NADP binding
I	0051287	molecular_function	NAD binding
I	0072524	biological_process	pyridine-containing compound metabolic process
J	0000166	molecular_function	nucleotide binding
J	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006006	biological_process	glucose metabolic process
J	0006096	biological_process	glycolytic process
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
J	0042802	molecular_function	identical protein binding
J	0050661	molecular_function	NADP binding
J	0051287	molecular_function	NAD binding
J	0072524	biological_process	pyridine-containing compound metabolic process
K	0000166	molecular_function	nucleotide binding
K	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006006	biological_process	glucose metabolic process
K	0006096	biological_process	glycolytic process
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
K	0042802	molecular_function	identical protein binding
K	0050661	molecular_function	NADP binding
K	0051287	molecular_function	NAD binding
K	0072524	biological_process	pyridine-containing compound metabolic process
L	0000166	molecular_function	nucleotide binding
L	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006006	biological_process	glucose metabolic process
L	0006096	biological_process	glycolytic process
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
L	0042802	molecular_function	identical protein binding
L	0050661	molecular_function	NADP binding
L	0051287	molecular_function	NAD binding
L	0072524	biological_process	pyridine-containing compound metabolic process
M	0000166	molecular_function	nucleotide binding
M	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006006	biological_process	glucose metabolic process
M	0006096	biological_process	glycolytic process
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
M	0042802	molecular_function	identical protein binding
M	0050661	molecular_function	NADP binding
M	0051287	molecular_function	NAD binding
M	0072524	biological_process	pyridine-containing compound metabolic process
N	0000166	molecular_function	nucleotide binding
N	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006006	biological_process	glucose metabolic process
N	0006096	biological_process	glycolytic process
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
N	0042802	molecular_function	identical protein binding
N	0050661	molecular_function	NADP binding
N	0051287	molecular_function	NAD binding
N	0072524	biological_process	pyridine-containing compound metabolic process
O	0000166	molecular_function	nucleotide binding
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006006	biological_process	glucose metabolic process
O	0006096	biological_process	glycolytic process
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0042802	molecular_function	identical protein binding
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
O	0072524	biological_process	pyridine-containing compound metabolic process
P	0000166	molecular_function	nucleotide binding
P	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006006	biological_process	glucose metabolic process
P	0006096	biological_process	glycolytic process
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0042802	molecular_function	identical protein binding
P	0050661	molecular_function	NADP binding
P	0051287	molecular_function	NAD binding
P	0072524	biological_process	pyridine-containing compound metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue AG A 401

Chain	Residue
A	CYS149
A	THR150
A	HIS176
A	ASN313

---

site_id	AC2
Number of Residues	4
Details	binding site for residue AG B 401

Chain	Residue
B	CYS149
B	THR150
B	HIS176
B	ASN313

---

site_id	AC3
Number of Residues	3
Details	binding site for residue AG C 401

Chain	Residue
C	THR150
C	HIS176
C	CYS149

---

site_id	AC4
Number of Residues	4
Details	binding site for residue AG D 401

Chain	Residue
D	CYS149
D	THR150
D	HIS176
D	ASN313

---

site_id	AC5
Number of Residues	3
Details	binding site for residue AG E 401

Chain	Residue
E	CYS149
E	THR150
E	HIS176

---

site_id	AC6
Number of Residues	4
Details	binding site for residue AG F 401

Chain	Residue
F	CYS149
F	THR150
F	HIS176
F	ASN313

---

site_id	AC7
Number of Residues	3
Details	binding site for residue AG G 401

Chain	Residue
G	CYS149
G	THR150
G	HIS176

---

site_id	AC8
Number of Residues	4
Details	binding site for residue AG H 401

Chain	Residue
H	CYS149
H	THR150
H	HIS176
H	ASN313

---

site_id	AC9
Number of Residues	3
Details	binding site for residue AG I 401

Chain	Residue
I	CYS149
I	THR150
I	HIS176

---

site_id	AD1
Number of Residues	4
Details	binding site for residue AG J 401

Chain	Residue
J	CYS149
J	THR150
J	HIS176
J	ASN313

---

site_id	AD2
Number of Residues	4
Details	binding site for residue AG K 401

Chain	Residue
K	CYS149
K	THR150
K	HIS176
K	TYR311

---

site_id	AD3
Number of Residues	4
Details	binding site for residue AG L 401

Chain	Residue
L	CYS149
L	THR150
L	HIS176
L	ASN313

---

site_id	AD4
Number of Residues	3
Details	binding site for residue AG M 401

Chain	Residue
M	CYS149
M	THR150
M	HIS176

---

site_id	AD5
Number of Residues	4
Details	binding site for residue AG N 401

Chain	Residue
N	CYS149
N	THR150
N	HIS176
N	TYR311

---

site_id	AD6
Number of Residues	4
Details	binding site for residue AG O 401

Chain	Residue
O	CYS149
O	THR150
O	HIS176
O	ASN313

---

site_id	AD7
Number of Residues	4
Details	binding site for residue AG P 401

Chain	Residue
P	CYS149
P	THR150
P	HIS176
P	ASN313

---

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
A	ALA147-LEU154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"10978154","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10978154","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19542219","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8636984","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2004","submissionDatabase":"PDB data bank","title":"Crystal structure of MES buffer bound form of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli.","authors":["Shin D.H.","Thor J.","Yokota H.","Kim R.","Kim S.H."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10978154","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19542219","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8636984","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10978154","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19542219","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19542219","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10978154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00362","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19542219","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2004","submissionDatabase":"PDB data bank","title":"Crystal structure of MES buffer bound form of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli.","authors":["Shin D.H.","Thor J.","Yokota H.","Kim R.","Kim S.H."]}},{"source":"PubMed","id":"10978154","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	Site: {"description":"Activates thiol group during catalysis","evidences":[{"source":"PubMed","id":"2659073","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	128
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	48
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---