6IMJ

The crystal structure of Se-AsfvLIG:DNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003909	molecular_function	DNA ligase activity
A	0003910	molecular_function	DNA ligase (ATP) activity
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0016874	molecular_function	ligase activity
A	0044423	cellular_component	virion component
A	0046872	molecular_function	metal ion binding
A	0051301	biological_process	cell division
B	0000166	molecular_function	nucleotide binding
B	0003909	molecular_function	DNA ligase activity
B	0003910	molecular_function	DNA ligase (ATP) activity
B	0005524	molecular_function	ATP binding
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0016874	molecular_function	ligase activity
B	0044423	cellular_component	virion component
B	0046872	molecular_function	metal ion binding
B	0051301	biological_process	cell division

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue ATP A 501

Chain	Residue
A	LEU128
A	PHE232
A	ILE294
A	ARG296
A	LYS316
A	CD503
A	CD504
A	HOH630
A	VAL129
A	GLN149
A	ARG150
A	LYS151
A	ARG152
A	ARG156
A	ARG172
A	GLU203

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CD A 502

Chain	Residue
A	LYS380
A	HIS381
A	ILE419

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CD A 503

Chain	Residue
A	ARG172
A	HIS310
A	ATP501

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CD A 504

Chain	Residue
A	LYS151
A	GLU291
A	ATP501

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CL A 505

Chain	Residue
A	ARG150
A	ARG152
A	GLU268

---

site_id	AC6
Number of Residues	17
Details	binding site for residue ATP B 501

Chain	Residue
B	LEU128
B	VAL129
B	GLN149
B	ARG150
B	LYS151
B	ARG152
B	ARG156
B	ARG172
B	GLU203
B	PHE232
B	ILE294
B	ARG296
B	LYS316
B	CD503
B	CD504
B	HOH602
B	HOH621

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CD B 502

Chain	Residue
B	LEU377
B	HIS381
B	ILE419

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CD B 503

Chain	Residue
B	HIS310
B	ATP501

---

site_id	AC9
Number of Residues	1
Details	binding site for residue CD B 504

Chain	Residue
B	ATP501

---

Functional Information from PROSITE/UniProt

site_id	PS00333
Number of Residues	28
Details	DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGAIVRnangp...YEpgynnyHsahlaKLK

Chain	Residue	Details
A	GLU291-LYS318

---

site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. QRKRNGVRA

Chain	Residue	Details
A	GLN149-ALA157

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"N6-AMP-lysine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10135","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30674878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Important for the catalytic efficiency","evidences":[{"source":"PubMed","id":"30674878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---