6IJR

Human PPARgamma ligand binding domain complexed with SB1495

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue A9C A 501

Chain	Residue
A	HIS266
A	ILE341
A	SER342
A	LEU353
A	MET364
A	THR268
A	ILE281
A	PHE282
A	CYS285
A	ARG288
A	SER289
A	TYR327
A	LEU330

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site_id	AC2
Number of Residues	17
Details	binding site for Di-peptide A9C C 501 and CYS C 285

Chain	Residue
C	HIS266
C	THR268
C	ILE281
C	PHE282
C	GLN283
C	GLY284
C	GLN286
C	PHE287
C	ARG288
C	SER289
C	TYR327
C	LEU330
C	ILE341
C	SER342
C	LEU353
C	PHE363
C	MET364

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER698
D	SER698
A	HIS449
A	TYR473
C	GLN286
C	HIS323
C	HIS449
C	TYR473

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649

Chain	Residue	Details
A	LYS224
C	LYS224

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