6IEN
Substrate/product bound Argininosuccinate lyase from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004056 | molecular_function | argininosuccinate lyase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016829 | molecular_function | lyase activity |
| A | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004056 | molecular_function | argininosuccinate lyase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006526 | biological_process | arginine biosynthetic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016829 | molecular_function | lyase activity |
| B | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004056 | molecular_function | argininosuccinate lyase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006526 | biological_process | arginine biosynthetic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009274 | cellular_component | peptidoglycan-based cell wall |
| C | 0016829 | molecular_function | lyase activity |
| C | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004056 | molecular_function | argininosuccinate lyase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006526 | biological_process | arginine biosynthetic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009274 | cellular_component | peptidoglycan-based cell wall |
| D | 0016829 | molecular_function | lyase activity |
| D | 0042450 | biological_process | arginine biosynthetic process via ornithine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue AS1 A 501 |
| Chain | Residue |
| A | SER113 |
| C | SER283 |
| C | MET285 |
| C | LYS288 |
| C | ASN290 |
| A | ARG114 |
| A | ASN115 |
| A | TYR322 |
| A | GLN327 |
| A | LYS330 |
| B | THR160 |
| B | HIS161 |
| C | SER282 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue FUM A 502 |
| Chain | Residue |
| A | SER282 |
| A | SER283 |
| A | LYS288 |
| A | ASN290 |
| C | SER113 |
| C | ARG114 |
| C | ASN115 |
| C | ARG501 |
| D | THR160 |
| D | HIS161 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | ALA90 |
| A | GLU93 |
| A | ILE97 |
| B | ARG387 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 504 |
| Chain | Residue |
| A | GLU86 |
| A | ARG114 |
| C | THR280 |
| C | GLY281 |
| C | SER282 |
| C | SER283 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue AS1 B 501 |
| Chain | Residue |
| A | THR160 |
| A | HIS161 |
| B | SER113 |
| B | ARG114 |
| B | ASN115 |
| B | VAL118 |
| B | TYR322 |
| B | GLN327 |
| B | LYS330 |
| B | HOH648 |
| D | SER282 |
| D | SER283 |
| D | MET285 |
| D | LYS288 |
| D | ASN290 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | ASP38 |
| B | SER42 |
| B | LEU92 |
| B | GLU93 |
| B | LEU108 |
| B | ARG112 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | GLU268 |
| B | ARG360 |
| C | ARG360 |
| C | EDO502 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | PHE79 |
| B | GLY80 |
| B | ARG94 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue ARG C 501 |
| Chain | Residue |
| A | FUM502 |
| C | ARG114 |
| C | ASN115 |
| C | VAL118 |
| C | TYR322 |
| C | GLN327 |
| C | LYS330 |
| C | HOH632 |
| D | HIS161 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 502 |
| Chain | Residue |
| B | ARG360 |
| B | EDO503 |
| C | GLU268 |
| C | ARG360 |
| site_id | AD2 |
| Number of Residues | 13 |
| Details | binding site for residue AS1 D 501 |
| Chain | Residue |
| B | SER282 |
| B | SER283 |
| B | MET285 |
| B | LYS288 |
| B | ASN290 |
| C | THR160 |
| C | HIS161 |
| D | SER113 |
| D | ARG114 |
| D | ASN115 |
| D | TYR322 |
| D | GLN327 |
| D | LYS330 |
Functional Information from PROSITE/UniProt
| site_id | PS00163 |
| Number of Residues | 10 |
| Details | FUMARATE_LYASES Fumarate lyases signature. GSsiMpQKkN |
| Chain | Residue | Details |
| A | GLY281-ASN290 |
