6IEH
Crystal structures of the hMTR4-NRDE2 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000176 | cellular_component | nuclear exosome (RNase complex) |
| B | 0000178 | cellular_component | exosome (RNase complex) |
| B | 0000398 | biological_process | mRNA splicing, via spliceosome |
| B | 0000460 | biological_process | maturation of 5.8S rRNA |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003689 | molecular_function | DNA clamp loader activity |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003724 | molecular_function | RNA helicase activity |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005681 | cellular_component | spliceosomal complex |
| B | 0005730 | cellular_component | nucleolus |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0006364 | biological_process | rRNA processing |
| B | 0006397 | biological_process | mRNA processing |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008380 | biological_process | RNA splicing |
| B | 0016076 | biological_process | snRNA catabolic process |
| B | 0016607 | cellular_component | nuclear speck |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0031499 | cellular_component | TRAMP complex |
| B | 0061775 | molecular_function | cohesin loader activity |
| B | 0071013 | cellular_component | catalytic step 2 spliceosome |
| B | 0140584 | molecular_function | chromatin extrusion motor activity |
| B | 0140588 | biological_process | chromatin looping |
| B | 0140665 | molecular_function | ATP-dependent H3-H4 histone complex chaperone activity |
| B | 0140849 | molecular_function | ATP-dependent H2AZ histone chaperone activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 1101 |
| Chain | Residue |
| B | MET726 |
| B | LEU750 |
| B | ARG756 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue ATP B 1102 |
| Chain | Residue |
| B | LYS167 |
| B | THR168 |
| B | LYS198 |
| B | ASP252 |
| B | GLU253 |
| B | ARG527 |
| B | PHE138 |
| B | ILE139 |
| B | GLN144 |
| B | THR163 |
| B | SER164 |
| B | GLY166 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31358741, ECO:0007744|PDB:6RO1 |
| Chain | Residue | Details |
| B | ILE139 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 |
| Chain | Residue | Details |
| B | ALA161 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29844170, ECO:0000269|PubMed:31358741, ECO:0007744|PDB:6C90, ECO:0007744|PDB:6RO1 |
| Chain | Residue | Details |
| B | SER164 | |
| B | GLY166 | |
| B | LYS167 | |
| B | THR168 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9CZU3 |
| Chain | Residue | Details |
| B | LYS78 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS358 | |
| B | LYS723 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS684 |
