Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6IE2

Crystal structure of methyladenine demethylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000791	cellular_component	euchromatin
A	0001701	biological_process	in utero embryonic development
A	0001764	biological_process	neuron migration
A	0001890	biological_process	placenta development
A	0002101	biological_process	tRNA wobble cytosine modification
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0006281	biological_process	DNA repair
A	0006307	biological_process	DNA alkylation repair
A	0006417	biological_process	regulation of translation
A	0006446	biological_process	regulation of translational initiation
A	0006448	biological_process	regulation of translational elongation
A	0008198	molecular_function	ferrous iron binding
A	0010468	biological_process	regulation of gene expression
A	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
A	0016829	molecular_function	lyase activity
A	0030154	biological_process	cell differentiation
A	0031175	biological_process	neuron projection development
A	0035513	biological_process	oxidative RNA demethylation
A	0035515	molecular_function	oxidative RNA demethylase activity
A	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
A	0042056	molecular_function	chemoattractant activity
A	0042245	biological_process	RNA repair
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0046872	molecular_function	metal ion binding
A	0048589	biological_process	developmental growth
A	0050918	biological_process	positive chemotaxis
A	0051213	molecular_function	dioxygenase activity
A	0070129	biological_process	regulation of mitochondrial translation
A	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0141131	molecular_function	DNA N6-methyladenine demethylase activity
A	0141137	biological_process	positive regulation of gene expression, epigenetic
A	1990983	biological_process	regulation of translational initiation by tRNA modification
A	1990984	molecular_function	tRNA demethylase activity
B	0000049	molecular_function	tRNA binding
B	0000791	cellular_component	euchromatin
B	0001701	biological_process	in utero embryonic development
B	0001764	biological_process	neuron migration
B	0001890	biological_process	placenta development
B	0002101	biological_process	tRNA wobble cytosine modification
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0006281	biological_process	DNA repair
B	0006307	biological_process	DNA alkylation repair
B	0006417	biological_process	regulation of translation
B	0006446	biological_process	regulation of translational initiation
B	0006448	biological_process	regulation of translational elongation
B	0008198	molecular_function	ferrous iron binding
B	0010468	biological_process	regulation of gene expression
B	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
B	0016829	molecular_function	lyase activity
B	0030154	biological_process	cell differentiation
B	0031175	biological_process	neuron projection development
B	0035513	biological_process	oxidative RNA demethylation
B	0035515	molecular_function	oxidative RNA demethylase activity
B	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
B	0042056	molecular_function	chemoattractant activity
B	0042245	biological_process	RNA repair
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0046872	molecular_function	metal ion binding
B	0048589	biological_process	developmental growth
B	0050918	biological_process	positive chemotaxis
B	0051213	molecular_function	dioxygenase activity
B	0070129	biological_process	regulation of mitochondrial translation
B	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0141131	molecular_function	DNA N6-methyladenine demethylase activity
B	0141137	biological_process	positive regulation of gene expression, epigenetic
B	1990983	biological_process	regulation of translational initiation by tRNA modification
B	1990984	molecular_function	tRNA demethylase activity
C	0000049	molecular_function	tRNA binding
C	0000791	cellular_component	euchromatin
C	0001701	biological_process	in utero embryonic development
C	0001764	biological_process	neuron migration
C	0001890	biological_process	placenta development
C	0002101	biological_process	tRNA wobble cytosine modification
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0006281	biological_process	DNA repair
C	0006307	biological_process	DNA alkylation repair
C	0006417	biological_process	regulation of translation
C	0006446	biological_process	regulation of translational initiation
C	0006448	biological_process	regulation of translational elongation
C	0008198	molecular_function	ferrous iron binding
C	0010468	biological_process	regulation of gene expression
C	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
C	0016829	molecular_function	lyase activity
C	0030154	biological_process	cell differentiation
C	0031175	biological_process	neuron projection development
C	0035513	biological_process	oxidative RNA demethylation
C	0035515	molecular_function	oxidative RNA demethylase activity
C	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
C	0042056	molecular_function	chemoattractant activity
C	0042245	biological_process	RNA repair
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0046872	molecular_function	metal ion binding
C	0048589	biological_process	developmental growth
C	0050918	biological_process	positive chemotaxis
C	0051213	molecular_function	dioxygenase activity
C	0070129	biological_process	regulation of mitochondrial translation
C	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C	0141131	molecular_function	DNA N6-methyladenine demethylase activity
C	0141137	biological_process	positive regulation of gene expression, epigenetic
C	1990983	biological_process	regulation of translational initiation by tRNA modification
C	1990984	molecular_function	tRNA demethylase activity
D	0000049	molecular_function	tRNA binding
D	0000791	cellular_component	euchromatin
D	0001701	biological_process	in utero embryonic development
D	0001764	biological_process	neuron migration
D	0001890	biological_process	placenta development
D	0002101	biological_process	tRNA wobble cytosine modification
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0006281	biological_process	DNA repair
D	0006307	biological_process	DNA alkylation repair
D	0006417	biological_process	regulation of translation
D	0006446	biological_process	regulation of translational initiation
D	0006448	biological_process	regulation of translational elongation
D	0008198	molecular_function	ferrous iron binding
D	0010468	biological_process	regulation of gene expression
D	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
D	0016829	molecular_function	lyase activity
D	0030154	biological_process	cell differentiation
D	0031175	biological_process	neuron projection development
D	0035513	biological_process	oxidative RNA demethylation
D	0035515	molecular_function	oxidative RNA demethylase activity
D	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
D	0042056	molecular_function	chemoattractant activity
D	0042245	biological_process	RNA repair
D	0043524	biological_process	negative regulation of neuron apoptotic process
D	0046872	molecular_function	metal ion binding
D	0048589	biological_process	developmental growth
D	0050918	biological_process	positive chemotaxis
D	0051213	molecular_function	dioxygenase activity
D	0070129	biological_process	regulation of mitochondrial translation
D	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D	0141131	molecular_function	DNA N6-methyladenine demethylase activity
D	0141137	biological_process	positive regulation of gene expression, epigenetic
D	1990983	biological_process	regulation of translational initiation by tRNA modification
D	1990984	molecular_function	tRNA demethylase activity
E	0000049	molecular_function	tRNA binding
E	0000791	cellular_component	euchromatin
E	0001701	biological_process	in utero embryonic development
E	0001764	biological_process	neuron migration
E	0001890	biological_process	placenta development
E	0002101	biological_process	tRNA wobble cytosine modification
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005783	cellular_component	endoplasmic reticulum
E	0006281	biological_process	DNA repair
E	0006307	biological_process	DNA alkylation repair
E	0006417	biological_process	regulation of translation
E	0006446	biological_process	regulation of translational initiation
E	0006448	biological_process	regulation of translational elongation
E	0008198	molecular_function	ferrous iron binding
E	0010468	biological_process	regulation of gene expression
E	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
E	0016829	molecular_function	lyase activity
E	0030154	biological_process	cell differentiation
E	0031175	biological_process	neuron projection development
E	0035513	biological_process	oxidative RNA demethylation
E	0035515	molecular_function	oxidative RNA demethylase activity
E	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
E	0042056	molecular_function	chemoattractant activity
E	0042245	biological_process	RNA repair
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0046872	molecular_function	metal ion binding
E	0048589	biological_process	developmental growth
E	0050918	biological_process	positive chemotaxis
E	0051213	molecular_function	dioxygenase activity
E	0070129	biological_process	regulation of mitochondrial translation
E	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E	0141131	molecular_function	DNA N6-methyladenine demethylase activity
E	0141137	biological_process	positive regulation of gene expression, epigenetic
E	1990983	biological_process	regulation of translational initiation by tRNA modification
E	1990984	molecular_function	tRNA demethylase activity
F	0000049	molecular_function	tRNA binding
F	0000791	cellular_component	euchromatin
F	0001701	biological_process	in utero embryonic development
F	0001764	biological_process	neuron migration
F	0001890	biological_process	placenta development
F	0002101	biological_process	tRNA wobble cytosine modification
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005783	cellular_component	endoplasmic reticulum
F	0006281	biological_process	DNA repair
F	0006307	biological_process	DNA alkylation repair
F	0006417	biological_process	regulation of translation
F	0006446	biological_process	regulation of translational initiation
F	0006448	biological_process	regulation of translational elongation
F	0008198	molecular_function	ferrous iron binding
F	0010468	biological_process	regulation of gene expression
F	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
F	0016829	molecular_function	lyase activity
F	0030154	biological_process	cell differentiation
F	0031175	biological_process	neuron projection development
F	0035513	biological_process	oxidative RNA demethylation
F	0035515	molecular_function	oxidative RNA demethylase activity
F	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
F	0042056	molecular_function	chemoattractant activity
F	0042245	biological_process	RNA repair
F	0043524	biological_process	negative regulation of neuron apoptotic process
F	0046872	molecular_function	metal ion binding
F	0048589	biological_process	developmental growth
F	0050918	biological_process	positive chemotaxis
F	0051213	molecular_function	dioxygenase activity
F	0070129	biological_process	regulation of mitochondrial translation
F	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F	0141131	molecular_function	DNA N6-methyladenine demethylase activity
F	0141137	biological_process	positive regulation of gene expression, epigenetic
F	1990983	biological_process	regulation of translational initiation by tRNA modification
F	1990984	molecular_function	tRNA demethylase activity
G	0000049	molecular_function	tRNA binding
G	0000791	cellular_component	euchromatin
G	0001701	biological_process	in utero embryonic development
G	0001764	biological_process	neuron migration
G	0001890	biological_process	placenta development
G	0002101	biological_process	tRNA wobble cytosine modification
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005783	cellular_component	endoplasmic reticulum
G	0006281	biological_process	DNA repair
G	0006307	biological_process	DNA alkylation repair
G	0006417	biological_process	regulation of translation
G	0006446	biological_process	regulation of translational initiation
G	0006448	biological_process	regulation of translational elongation
G	0008198	molecular_function	ferrous iron binding
G	0010468	biological_process	regulation of gene expression
G	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
G	0016829	molecular_function	lyase activity
G	0030154	biological_process	cell differentiation
G	0031175	biological_process	neuron projection development
G	0035513	biological_process	oxidative RNA demethylation
G	0035515	molecular_function	oxidative RNA demethylase activity
G	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
G	0042056	molecular_function	chemoattractant activity
G	0042245	biological_process	RNA repair
G	0043524	biological_process	negative regulation of neuron apoptotic process
G	0046872	molecular_function	metal ion binding
G	0048589	biological_process	developmental growth
G	0050918	biological_process	positive chemotaxis
G	0051213	molecular_function	dioxygenase activity
G	0070129	biological_process	regulation of mitochondrial translation
G	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G	0141131	molecular_function	DNA N6-methyladenine demethylase activity
G	0141137	biological_process	positive regulation of gene expression, epigenetic
G	1990983	biological_process	regulation of translational initiation by tRNA modification
G	1990984	molecular_function	tRNA demethylase activity
H	0000049	molecular_function	tRNA binding
H	0000791	cellular_component	euchromatin
H	0001701	biological_process	in utero embryonic development
H	0001764	biological_process	neuron migration
H	0001890	biological_process	placenta development
H	0002101	biological_process	tRNA wobble cytosine modification
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005783	cellular_component	endoplasmic reticulum
H	0006281	biological_process	DNA repair
H	0006307	biological_process	DNA alkylation repair
H	0006417	biological_process	regulation of translation
H	0006446	biological_process	regulation of translational initiation
H	0006448	biological_process	regulation of translational elongation
H	0008198	molecular_function	ferrous iron binding
H	0010468	biological_process	regulation of gene expression
H	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
H	0016829	molecular_function	lyase activity
H	0030154	biological_process	cell differentiation
H	0031175	biological_process	neuron projection development
H	0035513	biological_process	oxidative RNA demethylation
H	0035515	molecular_function	oxidative RNA demethylase activity
H	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
H	0042056	molecular_function	chemoattractant activity
H	0042245	biological_process	RNA repair
H	0043524	biological_process	negative regulation of neuron apoptotic process
H	0046872	molecular_function	metal ion binding
H	0048589	biological_process	developmental growth
H	0050918	biological_process	positive chemotaxis
H	0051213	molecular_function	dioxygenase activity
H	0070129	biological_process	regulation of mitochondrial translation
H	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H	0141131	molecular_function	DNA N6-methyladenine demethylase activity
H	0141137	biological_process	positive regulation of gene expression, epigenetic
H	1990983	biological_process	regulation of translational initiation by tRNA modification
H	1990984	molecular_function	tRNA demethylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MN A 400

Chain	Residue
A	HIS231
A	ASP233
A	HIS287
A	AKG401

site_id	AC2
Number of Residues	12
Details	binding site for residue AKG A 401

Chain	Residue
A	SER245
A	HIS287
A	VAL289
A	ARG338
A	ASN340
A	ARG344
A	MN400
A	ASN220
A	TYR222
A	LEU228
A	HIS231
A	ASP233

site_id	AC3
Number of Residues	4
Details	binding site for residue MN B 400

Chain	Residue
B	HIS231
B	ASP233
B	HIS287
B	AKG401

site_id	AC4
Number of Residues	12
Details	binding site for residue AKG B 401

Chain	Residue
B	ASN220
B	TYR222
B	HIS231
B	ASP233
B	SER245
B	HIS287
B	VAL289
B	ARG338
B	ASN340
B	THR342
B	ARG344
B	MN400

site_id	AC5
Number of Residues	4
Details	binding site for residue MN C 400

Chain	Residue
C	HIS231
C	ASP233
C	HIS287
C	AKG401

site_id	AC6
Number of Residues	11
Details	binding site for residue AKG C 401

Chain	Residue
C	ASN220
C	TYR222
C	LEU228
C	HIS231
C	ASP233
C	HIS287
C	VAL289
C	ARG338
C	ASN340
C	ARG344
C	MN400

site_id	AC7
Number of Residues	4
Details	binding site for residue MN D 400

Chain	Residue
D	HIS231
D	ASP233
D	HIS287
D	AKG401

site_id	AC8
Number of Residues	12
Details	binding site for residue AKG D 401

Chain	Residue
D	ASN220
D	TYR222
D	LEU228
D	HIS231
D	ASP233
D	MET270
D	HIS287
D	ARG338
D	ASN340
D	THR342
D	ARG344
D	MN400

site_id	AC9
Number of Residues	4
Details	binding site for residue MN E 400

Chain	Residue
E	HIS231
E	ASP233
E	HIS287
E	AKG401

site_id	AD1
Number of Residues	14
Details	binding site for residue AKG E 401

Chain	Residue
E	ASN220
E	TYR222
E	HIS231
E	ASP233
E	SER245
E	MET270
E	HIS287
E	VAL289
E	ARG338
E	ASN340
E	THR342
E	ARG344
E	MN400
E	HOH512

site_id	AD2
Number of Residues	4
Details	binding site for residue MN F 400

Chain	Residue
F	HIS231
F	ASP233
F	HIS287
F	AKG401

site_id	AD3
Number of Residues	12
Details	binding site for residue AKG F 401

Chain	Residue
F	ASN220
F	TYR222
F	LEU228
F	HIS231
F	ASP233
F	MET270
F	HIS287
F	VAL289
F	ARG338
F	ASN340
F	ARG344
F	MN400

site_id	AD4
Number of Residues	4
Details	binding site for residue MN G 400

Chain	Residue
G	HIS287
G	AKG401
G	HIS231
G	ASP233

site_id	AD5
Number of Residues	11
Details	binding site for residue AKG G 401

Chain	Residue
G	ASN220
G	TYR222
G	HIS231
G	ASP233
G	SER245
G	HIS287
G	VAL289
G	ARG338
G	ASN340
G	ARG344
G	MN400

site_id	AD6
Number of Residues	4
Details	binding site for residue MN H 400

Chain	Residue
H	HIS231
H	ASP233
H	HIS287
H	AKG401

site_id	AD7
Number of Residues	15
Details	binding site for residue AKG H 401

Chain	Residue
H	ASN220
H	TYR222
H	LEU228
H	HIS231
H	ASP233
H	SER245
H	MET270
H	MET276
H	HIS287
H	VAL289
H	ARG338
H	ASN340
H	THR342
H	ARG344
H	MN400

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q6NS38

Chain	Residue	Details
A	TRP144
D	TRP144
D	TYR175
D	ASP233
E	TRP144
E	TYR175
E	ASP233
F	TRP144
F	TYR175
F	ASP233
G	TRP144
A	TYR175
G	TYR175
G	ASP233
H	TRP144
H	TYR175
H	ASP233
A	ASP233
B	TRP144
B	TYR175
B	ASP233
C	TRP144
C	TYR175
C	ASP233

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q96Q83

Chain	Residue	Details
A	ASN220
E	ARG338
F	ASN220
F	ARG338
G	ASN220
G	ARG338
H	ASN220
H	ARG338
A	ARG338
B	ASN220
B	ARG338
C	ASN220
C	ARG338
D	ASN220
D	ARG338
E	ASN220

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00805, ECO:0000305\|PubMed:19959401, ECO:0000305\|PubMed:27745969

Chain	Residue	Details
A	HIS231
B	HIS231
C	HIS231
D	HIS231
E	HIS231
F	HIS231
G	HIS231
H	HIS231

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00805

Chain	Residue	Details
A	HIS287
B	HIS287
C	HIS287
D	HIS287
E	HIS287
F	HIS287
G	HIS287
H	HIS287

site_id	SWS_FT_FI5
Number of Residues	8
Details	SITE: Secondary catalytic residue forming the imine linkage with DNA => ECO:0000269\|PubMed:23577621

Chain	Residue	Details
A	LYS133
B	LYS133
C	LYS133
D	LYS133
E	LYS133
F	LYS133
G	LYS133
H	LYS133

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)