6IB5
Mutant of flavin-dependent tryptophan halogenase Thal with altered regioselectivity (Thal-RebH5)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0016491 | molecular_function | oxidoreductase activity |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | binding site for residue PO4 A 601 |
Chain | Residue |
A | ARG158 |
A | ARG164 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue GOL A 602 |
Chain | Residue |
A | ARG44 |
A | ASN327 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue GOL A 603 |
Chain | Residue |
A | HIS263 |
A | ASP264 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue GOL A 604 |
Chain | Residue |
A | GLY361 |
A | ILE362 |
A | HOH827 |
A | THR15 |
A | GLU49 |
A | LEU349 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue GOL A 605 |
Chain | Residue |
A | ARG337 |
A | ARG338 |
B | VAL186 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue GOL A 606 |
Chain | Residue |
A | ASP301 |
A | HIS302 |
A | PHE303 |
A | ALA304 |
A | THR305 |
A | GLU308 |
A | HOH866 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue GOL A 607 |
Chain | Residue |
A | HIS250 |
A | ASP398 |
A | ARG401 |
site_id | AC8 |
Number of Residues | 1 |
Details | binding site for residue PO4 B 601 |
Chain | Residue |
B | ARG338 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue PO4 B 602 |
Chain | Residue |
B | HIS250 |
B | ARG401 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue PO4 B 603 |
Chain | Residue |
B | ARG439 |
B | ARG483 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue GOL B 604 |
Chain | Residue |
A | LYS432 |
A | ARG439 |
B | GLU205 |
site_id | AD3 |
Number of Residues | 3 |
Details | binding site for residue GOL B 605 |
Chain | Residue |
B | THR15 |
B | GLU49 |
B | GLY361 |
site_id | AD4 |
Number of Residues | 2 |
Details | binding site for residue GOL B 606 |
Chain | Residue |
B | LEU202 |
B | THR203 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue GOL B 607 |
Chain | Residue |
A | ARG206 |
B | ARG4 |
B | LYS6 |
B | THR31 |
site_id | AD6 |
Number of Residues | 6 |
Details | binding site for residue GOL B 608 |
Chain | Residue |
A | GLU205 |
A | ARG206 |
A | GLY207 |
B | LYS33 |
B | HOH719 |
B | HOH820 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:30559288, ECO:0000305|PubMed:33465708 |
Chain | Residue | Details |
A | LYS79 | |
B | LYS79 |
site_id | SWS_FT_FI2 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:31589794, ECO:0000269|PubMed:33465708, ECO:0007744|PDB:6SLS, ECO:0007744|PDB:6SLT, ECO:0007744|PDB:7CU1 |
Chain | Residue | Details |
A | GLY13 | |
B | ALA16 | |
B | ILE42 | |
B | ILE45 | |
B | ALA50 | |
B | MET198 | |
B | LEU349 | |
B | ILE362 | |
A | ALA16 | |
A | ILE42 | |
A | ILE45 | |
A | ALA50 | |
A | MET198 | |
A | LEU349 | |
A | ILE362 | |
B | GLY13 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33465708, ECO:0007744|PDB:7CU1 |
Chain | Residue | Details |
A | THR15 | |
B | THR15 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:31589794, ECO:0007744|PDB:6SLS |
Chain | Residue | Details |
A | ALA39 | |
B | ALA39 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:31589794, ECO:0007744|PDB:6SLS, ECO:0007744|PDB:6SLT |
Chain | Residue | Details |
A | VAL47 | |
B | VAL47 |
site_id | SWS_FT_FI6 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30559288, ECO:0000269|PubMed:31589794, ECO:0000269|PubMed:33465708, ECO:0007744|PDB:6H44, ECO:0007744|PDB:6SLT, ECO:0007744|PDB:7CU0 |
Chain | Residue | Details |
A | PRO111 | |
B | PHE465 | |
A | TYR454 | |
A | TYR455 | |
A | GLU461 | |
A | PHE465 | |
B | PRO111 | |
B | TYR454 | |
B | TYR455 | |
B | GLU461 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:E9P162 |
Chain | Residue | Details |
A | THR360 | |
A | GLY361 | |
B | THR360 | |
B | GLY361 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | SITE: Important for activity => ECO:0000250|UniProtKB:P95480 |
Chain | Residue | Details |
A | GLU358 | |
B | GLU358 |