6IB5
Mutant of flavin-dependent tryptophan halogenase Thal with altered regioselectivity (Thal-RebH5)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 A 601 |
| Chain | Residue |
| A | ARG158 |
| A | ARG164 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | ARG44 |
| A | ASN327 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | HIS263 |
| A | ASP264 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | GLY361 |
| A | ILE362 |
| A | HOH827 |
| A | THR15 |
| A | GLU49 |
| A | LEU349 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 605 |
| Chain | Residue |
| A | ARG337 |
| A | ARG338 |
| B | VAL186 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 606 |
| Chain | Residue |
| A | ASP301 |
| A | HIS302 |
| A | PHE303 |
| A | ALA304 |
| A | THR305 |
| A | GLU308 |
| A | HOH866 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 607 |
| Chain | Residue |
| A | HIS250 |
| A | ASP398 |
| A | ARG401 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 B 601 |
| Chain | Residue |
| B | ARG338 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 602 |
| Chain | Residue |
| B | HIS250 |
| B | ARG401 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 603 |
| Chain | Residue |
| B | ARG439 |
| B | ARG483 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| A | LYS432 |
| A | ARG439 |
| B | GLU205 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | THR15 |
| B | GLU49 |
| B | GLY361 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 606 |
| Chain | Residue |
| B | LEU202 |
| B | THR203 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 607 |
| Chain | Residue |
| A | ARG206 |
| B | ARG4 |
| B | LYS6 |
| B | THR31 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 608 |
| Chain | Residue |
| A | GLU205 |
| A | ARG206 |
| A | GLY207 |
| B | LYS33 |
| B | HOH719 |
| B | HOH820 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"30559288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CU1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CU1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SLS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SLT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30559288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H44","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CU0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"E9P162","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for activity","evidences":[{"source":"UniProtKB","id":"P95480","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
