6I8B
Crystal structure of Spindlin1 in complex with the inhibitor VinSpinIn
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue H7T B 301 |
| Chain | Residue |
| B | TRP62 |
| B | TYR170 |
| B | TYR177 |
| B | TYR179 |
| B | ASP184 |
| B | DMS303 |
| B | TRP72 |
| B | TYR91 |
| B | PHE94 |
| B | ASP95 |
| B | TYR98 |
| B | HIS139 |
| B | PHE141 |
| B | TRP151 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue DMS B 302 |
| Chain | Residue |
| B | PRO81 |
| B | TYR185 |
| B | LYS186 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 303 |
| Chain | Residue |
| B | PHE94 |
| B | ASP95 |
| B | CYS96 |
| B | TYR98 |
| B | H7T301 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue DMS B 304 |
| Chain | Residue |
| B | LYS260 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue DMS B 305 |
| Chain | Residue |
| B | GLU64 |
| B | THR70 |
| E | ASN52 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue GLY B 306 |
| Chain | Residue |
| B | MET154 |
| B | GLU171 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 E 301 |
| Chain | Residue |
| E | PRO81 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | binding site for residue H7T E 302 |
| Chain | Residue |
| B | ARG51 |
| B | VAL118 |
| B | ALA119 |
| E | TRP62 |
| E | TRP72 |
| E | TYR91 |
| E | ASP95 |
| E | TYR98 |
| E | HIS139 |
| E | PHE141 |
| E | GLU142 |
| E | TRP151 |
| E | TYR170 |
| E | TYR177 |
| E | TYR179 |
| E | ASP184 |
| E | DMS303 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue DMS E 303 |
| Chain | Residue |
| E | PHE94 |
| E | ASP95 |
| E | CYS96 |
| E | TYR98 |
| E | H7T302 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue GLY E 304 |
| Chain | Residue |
| E | MET154 |
| E | GLU171 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 126 |
| Details | Region: {"description":"Tudor-like domain 1","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Site: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKA","evidences":[{"source":"PubMed","id":"22258766","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 61 |
| Details | Region: {"description":"Tudor-like domain 2","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
