6I8B

Crystal structure of Spindlin1 in complex with the inhibitor VinSpinIn

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0007276	biological_process	gamete generation
E	0007276	biological_process	gamete generation

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue H7T B 301

Chain	Residue
B	TRP62
B	TYR170
B	TYR177
B	TYR179
B	ASP184
B	DMS303
B	TRP72
B	TYR91
B	PHE94
B	ASP95
B	TYR98
B	HIS139
B	PHE141
B	TRP151

---

site_id	AC2
Number of Residues	3
Details	binding site for residue DMS B 302

Chain	Residue
B	PRO81
B	TYR185
B	LYS186

---

site_id	AC3
Number of Residues	5
Details	binding site for residue DMS B 303

Chain	Residue
B	PHE94
B	ASP95
B	CYS96
B	TYR98
B	H7T301

---

site_id	AC4
Number of Residues	1
Details	binding site for residue DMS B 304

Chain	Residue
B	LYS260

---

site_id	AC5
Number of Residues	3
Details	binding site for residue DMS B 305

Chain	Residue
B	GLU64
B	THR70
E	ASN52

---

site_id	AC6
Number of Residues	2
Details	binding site for residue GLY B 306

Chain	Residue
B	MET154
B	GLU171

---

site_id	AC7
Number of Residues	1
Details	binding site for residue PO4 E 301

Chain	Residue
E	PRO81

---

site_id	AC8
Number of Residues	17
Details	binding site for residue H7T E 302

Chain	Residue
B	ARG51
B	VAL118
B	ALA119
E	TRP62
E	TRP72
E	TYR91
E	ASP95
E	TYR98
E	HIS139
E	PHE141
E	GLU142
E	TRP151
E	TYR170
E	TYR177
E	TYR179
E	ASP184
E	DMS303

---

site_id	AC9
Number of Residues	5
Details	binding site for residue DMS E 303

Chain	Residue
E	PHE94
E	ASP95
E	CYS96
E	TYR98
E	H7T302

---

site_id	AD1
Number of Residues	2
Details	binding site for residue GLY E 304

Chain	Residue
E	MET154
E	GLU171

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	SITE: Histone H3K4me3 and H3R8me2a binding

Chain	Residue	Details
B	ASP173
B	GLN180
B	ASP184
E	ASP173
E	GLN180
E	ASP184

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by AURKA => ECO:0000269|PubMed:22258766

Chain	Residue	Details
B	SER109
E	SER109

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by AURKA => ECO:0000269|PubMed:22258766, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER124
E	SER124

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER199
E	SER199

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