6I80
Crystal Structure of the second bromodomain of BRD2 in complex with RT53
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue H7B A 501 |
| Chain | Residue |
| A | TRP370 |
| A | HOH617 |
| A | HOH703 |
| A | HOH710 |
| A | PRO371 |
| A | TYR428 |
| A | ASN429 |
| A | HIS433 |
| A | VAL435 |
| A | EDO502 |
| A | EDO502 |
| A | HOH608 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | TRP370 |
| A | ASP377 |
| A | ALA380 |
| A | H7B501 |
| A | H7B501 |
| A | HOH632 |
| A | HOH660 |
| A | HOH751 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue H7B B 501 |
| Chain | Residue |
| A | ARG401 |
| A | HOH761 |
| B | TRP370 |
| B | PRO371 |
| B | ASN429 |
| B | HIS433 |
| B | VAL435 |
| B | MET438 |
| B | HOH613 |
| B | HOH645 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFykpvDasalglhDYHdiIkhpMdlstVkrkmenrd..Yrdaqefaadvrl.MfsNCykY |
| Chain | Residue | Details |
| A | ALA369-TYR428 |
