6I7S
Microsomal triglyceride transfer protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003756 | molecular_function | protein disulfide isomerase activity |
| A | 0003779 | molecular_function | actin binding |
| A | 0004656 | molecular_function | procollagen-proline 4-dioxygenase activity |
| A | 0005178 | molecular_function | integrin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006457 | biological_process | protein folding |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0015035 | molecular_function | protein-disulfide reductase activity |
| A | 0016222 | cellular_component | procollagen-proline 4-dioxygenase complex |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016972 | molecular_function | thiol oxidase activity |
| A | 0018401 | biological_process | peptidyl-proline hydroxylation to 4-hydroxy-L-proline |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030027 | cellular_component | lamellipodium |
| A | 0030070 | biological_process | insulin processing |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034663 | cellular_component | endoplasmic reticulum chaperone complex |
| A | 0034975 | biological_process | protein folding in endoplasmic reticulum |
| A | 0034976 | biological_process | response to endoplasmic reticulum stress |
| A | 0035722 | biological_process | interleukin-12-mediated signaling pathway |
| A | 0038155 | biological_process | interleukin-23-mediated signaling pathway |
| A | 0042470 | cellular_component | melanosome |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045785 | biological_process | positive regulation of cell adhesion |
| A | 0046598 | biological_process | positive regulation of viral entry into host cell |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071456 | biological_process | cellular response to hypoxia |
| A | 1900026 | biological_process | positive regulation of substrate adhesion-dependent cell spreading |
| A | 1902175 | biological_process | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| A | 2000406 | biological_process | positive regulation of T cell migration |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003756 | molecular_function | protein disulfide isomerase activity |
| B | 0003779 | molecular_function | actin binding |
| B | 0004656 | molecular_function | procollagen-proline 4-dioxygenase activity |
| B | 0005178 | molecular_function | integrin binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
| B | 0005829 | cellular_component | cytosol |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0006457 | biological_process | protein folding |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0015035 | molecular_function | protein-disulfide reductase activity |
| B | 0016222 | cellular_component | procollagen-proline 4-dioxygenase complex |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016972 | molecular_function | thiol oxidase activity |
| B | 0018401 | biological_process | peptidyl-proline hydroxylation to 4-hydroxy-L-proline |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0030027 | cellular_component | lamellipodium |
| B | 0030070 | biological_process | insulin processing |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0034663 | cellular_component | endoplasmic reticulum chaperone complex |
| B | 0034975 | biological_process | protein folding in endoplasmic reticulum |
| B | 0034976 | biological_process | response to endoplasmic reticulum stress |
| B | 0035722 | biological_process | interleukin-12-mediated signaling pathway |
| B | 0038155 | biological_process | interleukin-23-mediated signaling pathway |
| B | 0042470 | cellular_component | melanosome |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045785 | biological_process | positive regulation of cell adhesion |
| B | 0046598 | biological_process | positive regulation of viral entry into host cell |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071456 | biological_process | cellular response to hypoxia |
| B | 1900026 | biological_process | positive regulation of substrate adhesion-dependent cell spreading |
| B | 1902175 | biological_process | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| B | 2000406 | biological_process | positive regulation of T cell migration |
| G | 0005319 | molecular_function | lipid transporter activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005548 | molecular_function | phospholipid transporter activity |
| G | 0005783 | cellular_component | endoplasmic reticulum |
| G | 0005788 | cellular_component | endoplasmic reticulum lumen |
| G | 0005794 | cellular_component | Golgi apparatus |
| G | 0006629 | biological_process | lipid metabolic process |
| G | 0006869 | biological_process | lipid transport |
| G | 0007623 | biological_process | circadian rhythm |
| G | 0008289 | molecular_function | lipid binding |
| G | 0009306 | biological_process | protein secretion |
| G | 0015914 | biological_process | phospholipid transport |
| G | 0015918 | biological_process | sterol transport |
| G | 0016323 | cellular_component | basolateral plasma membrane |
| G | 0031526 | cellular_component | brush border membrane |
| G | 0031528 | cellular_component | microvillus membrane |
| G | 0031982 | cellular_component | vesicle |
| G | 0034185 | molecular_function | apolipoprotein binding |
| G | 0034197 | biological_process | triglyceride transport |
| G | 0034377 | biological_process | plasma lipoprotein particle assembly |
| G | 0034378 | biological_process | chylomicron assembly |
| G | 0034379 | biological_process | very-low-density lipoprotein particle assembly |
| G | 0042157 | biological_process | lipoprotein metabolic process |
| G | 0042632 | biological_process | cholesterol homeostasis |
| G | 0043235 | cellular_component | receptor complex |
| G | 0044877 | molecular_function | protein-containing complex binding |
| G | 0046982 | molecular_function | protein heterodimerization activity |
| G | 0051592 | biological_process | response to calcium ion |
| G | 0120009 | biological_process | intermembrane lipid transfer |
| G | 0120014 | molecular_function | phospholipid transfer activity |
| G | 0120019 | molecular_function | phosphatidylcholine transfer activity |
| G | 0120020 | molecular_function | cholesterol transfer activity |
| G | 0140344 | molecular_function | triglyceride transfer activity |
| G | 1902388 | molecular_function | ceramide 1-phosphate transfer activity |
| G | 1902389 | biological_process | ceramide 1-phosphate transport |
| G | 1904121 | molecular_function | phosphatidylethanolamine transfer activity |
| H | 0005319 | molecular_function | lipid transporter activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005548 | molecular_function | phospholipid transporter activity |
| H | 0005783 | cellular_component | endoplasmic reticulum |
| H | 0005788 | cellular_component | endoplasmic reticulum lumen |
| H | 0005794 | cellular_component | Golgi apparatus |
| H | 0006629 | biological_process | lipid metabolic process |
| H | 0006869 | biological_process | lipid transport |
| H | 0007623 | biological_process | circadian rhythm |
| H | 0008289 | molecular_function | lipid binding |
| H | 0009306 | biological_process | protein secretion |
| H | 0015914 | biological_process | phospholipid transport |
| H | 0015918 | biological_process | sterol transport |
| H | 0016323 | cellular_component | basolateral plasma membrane |
| H | 0031526 | cellular_component | brush border membrane |
| H | 0031528 | cellular_component | microvillus membrane |
| H | 0031982 | cellular_component | vesicle |
| H | 0034185 | molecular_function | apolipoprotein binding |
| H | 0034197 | biological_process | triglyceride transport |
| H | 0034377 | biological_process | plasma lipoprotein particle assembly |
| H | 0034378 | biological_process | chylomicron assembly |
| H | 0034379 | biological_process | very-low-density lipoprotein particle assembly |
| H | 0042157 | biological_process | lipoprotein metabolic process |
| H | 0042632 | biological_process | cholesterol homeostasis |
| H | 0043235 | cellular_component | receptor complex |
| H | 0044877 | molecular_function | protein-containing complex binding |
| H | 0046982 | molecular_function | protein heterodimerization activity |
| H | 0051592 | biological_process | response to calcium ion |
| H | 0120009 | biological_process | intermembrane lipid transfer |
| H | 0120014 | molecular_function | phospholipid transfer activity |
| H | 0120019 | molecular_function | phosphatidylcholine transfer activity |
| H | 0120020 | molecular_function | cholesterol transfer activity |
| H | 0140344 | molecular_function | triglyceride transfer activity |
| H | 1902388 | molecular_function | ceramide 1-phosphate transfer activity |
| H | 1902389 | biological_process | ceramide 1-phosphate transport |
| H | 1904121 | molecular_function | phosphatidylethanolamine transfer activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 601 |
| Chain | Residue |
| A | ALA381 |
| A | ASP383 |
| A | LYS386 |
| A | PHE446 |
| A | PRO447 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | LYS162 |
| A | SER190 |
| A | ASP199 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 603 |
| Chain | Residue |
| A | SER153 |
| A | GLU154 |
| A | PHE206 |
| A | LYS207 |
| A | LYS208 |
| A | VAL150 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 604 |
| Chain | Residue |
| A | LYS276 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 605 |
| Chain | Residue |
| A | LYS415 |
| A | HOH714 |
| G | LYS195 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | GLY349 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 601 |
| Chain | Residue |
| B | ALA381 |
| B | ASP383 |
| B | LYS386 |
| B | PHE446 |
| B | PRO447 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue PGE B 602 |
| Chain | Residue |
| B | ALA118 |
| B | ARG120 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue PGE B 603 |
| Chain | Residue |
| B | TYR327 |
| B | GLY349 |
| G | LYS103 |
| G | LYS105 |
| G | LYS109 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 604 |
| Chain | Residue |
| B | GLU322 |
| B | GLU323 |
| B | MET324 |
| B | HOH708 |
| H | ARG594 |
| H | HIS603 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 605 |
| Chain | Residue |
| B | VAL237 |
| B | LYS276 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 606 |
| Chain | Residue |
| B | TYR49 |
| B | CYS56 |
| B | LYS81 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 607 |
| Chain | Residue |
| B | ASN419 |
| G | LYS278 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 608 |
| Chain | Residue |
| B | GLU177 |
| B | ALA178 |
| B | LYS222 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 609 |
| Chain | Residue |
| B | HIS438 |
| G | GLN95 |
| H | HOH1039 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue PE5 G 901 |
| Chain | Residue |
| G | SER646 |
| G | SER662 |
| G | ASN780 |
| G | ALA809 |
| G | PHE813 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue PGE G 902 |
| Chain | Residue |
| G | GLU391 |
| G | TYR395 |
| G | VAL728 |
| G | HOH1003 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue TRS G 903 |
| Chain | Residue |
| G | VAL227 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 G 904 |
| Chain | Residue |
| G | GLY850 |
| G | ARG851 |
| G | GLY852 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 G 905 |
| Chain | Residue |
| G | GLU90 |
| G | ASN91 |
| G | PHE102 |
| G | HOH1006 |
| G | HOH1012 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 G 906 |
| Chain | Residue |
| G | GLU536 |
| G | LYS537 |
| G | THR538 |
| G | ARG644 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 G 907 |
| Chain | Residue |
| G | SER39 |
| G | ARG58 |
| G | LYS255 |
| G | HOH1016 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 G 908 |
| Chain | Residue |
| G | SER768 |
| G | LEU769 |
| G | TRP770 |
| H | ILE196 |
| H | ALA197 |
| H | ARG198 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 G 909 |
| Chain | Residue |
| A | ARG300 |
| G | GLN569 |
| G | ARG610 |
| G | SER611 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 G 910 |
| Chain | Residue |
| G | ILE188 |
| G | ALA190 |
| site_id | AE8 |
| Number of Residues | 1 |
| Details | binding site for residue EDO G 911 |
| Chain | Residue |
| G | ARG623 |
| site_id | AE9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO G 912 |
| Chain | Residue |
| G | ARG121 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO G 913 |
| Chain | Residue |
| G | ASN140 |
| G | GLU141 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO G 914 |
| Chain | Residue |
| G | SER296 |
| G | LYS748 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO G 915 |
| Chain | Residue |
| G | ARG312 |
| G | ASN352 |
| site_id | AF4 |
| Number of Residues | 9 |
| Details | binding site for residue EDO G 916 |
| Chain | Residue |
| G | PHE399 |
| G | ALA400 |
| G | SER401 |
| G | ILE732 |
| G | LEU733 |
| G | HOH1011 |
| G | SER365 |
| G | GLN367 |
| G | ALA396 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue PEG G 918 |
| Chain | Residue |
| G | GLN509 |
| G | ASN549 |
| G | HIS660 |
| G | GLN663 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue PE5 H 901 |
| Chain | Residue |
| H | SER646 |
| H | SER662 |
| H | ASN780 |
| H | PHE813 |
| site_id | AF7 |
| Number of Residues | 8 |
| Details | binding site for residue PE4 H 902 |
| Chain | Residue |
| H | LYS99 |
| H | THR849 |
| H | GLY850 |
| H | ARG851 |
| H | GLY852 |
| H | VAL854 |
| H | GLN856 |
| H | HOH1055 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue PGE H 903 |
| Chain | Residue |
| H | GLN509 |
| H | ARG510 |
| H | TYR511 |
| H | ASP512 |
| H | PHE651 |
| site_id | AF9 |
| Number of Residues | 1 |
| Details | binding site for residue PGE H 904 |
| Chain | Residue |
| H | TYR554 |
| site_id | AG1 |
| Number of Residues | 3 |
| Details | binding site for residue PGE H 905 |
| Chain | Residue |
| H | SER27 |
| H | PHE226 |
| H | VAL227 |
| site_id | AG2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 H 906 |
| Chain | Residue |
| G | ARG32 |
| G | ALA263 |
| H | THR517 |
| H | ASP518 |
| site_id | AG3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 H 907 |
| Chain | Residue |
| H | GLN569 |
| H | ARG610 |
| H | SER611 |
| H | HOH1005 |
| site_id | AG4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 H 908 |
| Chain | Residue |
| H | GLN530 |
| H | ARG540 |
| H | PRO568 |
| site_id | AG5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO H 909 |
| Chain | Residue |
| H | THR705 |
| H | HOH1040 |
| site_id | AG6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO H 910 |
| Chain | Residue |
| H | ARG312 |
| H | ASN352 |
| site_id | AG7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO H 911 |
| Chain | Residue |
| H | PRO204 |
| H | ASN205 |
| H | GLN441 |
| site_id | AG8 |
| Number of Residues | 1 |
| Details | binding site for residue EDO H 912 |
| Chain | Residue |
| H | TYR314 |
| site_id | AG9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO H 913 |
| Chain | Residue |
| H | THR165 |
| H | ASN166 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue PEG H 914 |
| Chain | Residue |
| H | TYR395 |
| H | PHE399 |
| H | LEU701 |
| H | VAL728 |
| H | GLY730 |
| site_id | AH2 |
| Number of Residues | 1 |
| Details | binding site for residue PEG H 915 |
| Chain | Residue |
| H | MET692 |
| site_id | AH3 |
| Number of Residues | 2 |
| Details | binding site for residue PEG H 916 |
| Chain | Residue |
| G | SER269 |
| H | LYS859 |
| site_id | AH4 |
| Number of Residues | 5 |
| Details | binding site for residue PEG H 917 |
| Chain | Residue |
| H | THR37 |
| H | TYR38 |
| H | SER39 |
| H | SER61 |
| H | LYS255 |
| site_id | AH5 |
| Number of Residues | 1 |
| Details | binding site for residue PEG H 918 |
| Chain | Residue |
| H | GLY200 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 252 |
| Details | Domain: {"description":"Thioredoxin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Contributes to redox potential value"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Lowers pKa of C-terminal Cys of first active site"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Contributes to redox potential value","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Site: {"description":"Lowers pKa of C-terminal Cys of second active site","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P09103","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P09103","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"32149426","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32149426","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1262 |
| Details | Domain: {"description":"Vitellogenin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00557","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 191 |
| Chain | Residue | Details |
| A | CYS53 | nucleofuge, nucleophile, proton acceptor, proton donor |
| A | GLY54 | activator, modifies pKa |
| A | HIS55 | modifies pKa, proton acceptor, proton donor |
| A | CYS56 |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 191 |
| Chain | Residue | Details |
| B | CYS53 | nucleofuge, nucleophile, proton acceptor, proton donor |
| B | GLY54 | activator, modifies pKa |
| B | HIS55 | modifies pKa, proton acceptor, proton donor |
| B | CYS56 |
