6I6X
New Irreversible a-l-Iduronidase Inhibitors and Activity-Based Probes
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS01027 |
| Number of Residues | 10 |
| Details | GLYCOSYL_HYDROL_F39 Glycosyl hydrolases family 39 active site. WnFEtWNEPD |
| Chain | Residue | Details |
| B | TRP175-ASP184 | |
| A | TRP175-ASP184 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10068, ECO:0000269|PubMed:24036510 |
| Chain | Residue | Details |
| B | GLU182 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:24036510 |
| Chain | Residue | Details |
| B | GLU299 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGL |
| Chain | Residue | Details |
| B | PRO54 | |
| B | LEU56 | |
| B | HIS58 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W82 |
| Chain | Residue | Details |
| B | HIS91 | |
| B | ASN181 | |
| B | GLU182 | |
| B | LYS264 | |
| B | GLU299 | |
| B | GLY305 | |
| B | ASP349 | |
| B | ARG363 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGJ, ECO:0007744|PDB:4KH2 |
| Chain | Residue | Details |
| B | TRP306 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82 |
| Chain | Residue | Details |
| B | ARG488 | |
| B | ARG492 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGJ, ECO:0007744|PDB:4KGL, ECO:0007744|PDB:4KH2, ECO:0007744|PDB:4MJ2, ECO:0007744|PDB:4MJ4 |
| Chain | Residue | Details |
| B | ASN110 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82 |
| Chain | Residue | Details |
| B | ASN190 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| B | ASN336 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGJ, ECO:0007744|PDB:4KGL, ECO:0007744|PDB:4KH2, ECO:0007744|PDB:4MJ2, ECO:0007744|PDB:4MJ4 |
| Chain | Residue | Details |
| B | ASN372 | |
| B | ASN415 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W81 |
| Chain | Residue | Details |
| B | ASN451 |
