6I34
Crystal structure of Neanderthal glycine decarboxylase (P-protein)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004375 | molecular_function | glycine dehydrogenase (decarboxylating) activity |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0005886 | cellular_component | plasma membrane |
A | 0005960 | cellular_component | glycine cleavage complex |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0006544 | biological_process | glycine metabolic process |
A | 0006546 | biological_process | glycine catabolic process |
A | 0009055 | molecular_function | electron transfer activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016594 | molecular_function | glycine binding |
A | 0016829 | molecular_function | lyase activity |
A | 0019464 | biological_process | glycine decarboxylation via glycine cleavage system |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0036255 | biological_process | response to methylamine |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0070280 | molecular_function | pyridoxal binding |
A | 1903442 | biological_process | response to lipoic acid |
A | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
B | 0004375 | molecular_function | glycine dehydrogenase (decarboxylating) activity |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0005886 | cellular_component | plasma membrane |
B | 0005960 | cellular_component | glycine cleavage complex |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0006544 | biological_process | glycine metabolic process |
B | 0006546 | biological_process | glycine catabolic process |
B | 0009055 | molecular_function | electron transfer activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016594 | molecular_function | glycine binding |
B | 0016829 | molecular_function | lyase activity |
B | 0019464 | biological_process | glycine decarboxylation via glycine cleavage system |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0036255 | biological_process | response to methylamine |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0070280 | molecular_function | pyridoxal binding |
B | 1903442 | biological_process | response to lipoic acid |
B | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
C | 0004375 | molecular_function | glycine dehydrogenase (decarboxylating) activity |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005739 | cellular_component | mitochondrion |
C | 0005759 | cellular_component | mitochondrial matrix |
C | 0005886 | cellular_component | plasma membrane |
C | 0005960 | cellular_component | glycine cleavage complex |
C | 0006520 | biological_process | amino acid metabolic process |
C | 0006544 | biological_process | glycine metabolic process |
C | 0006546 | biological_process | glycine catabolic process |
C | 0009055 | molecular_function | electron transfer activity |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016594 | molecular_function | glycine binding |
C | 0016829 | molecular_function | lyase activity |
C | 0019464 | biological_process | glycine decarboxylation via glycine cleavage system |
C | 0030170 | molecular_function | pyridoxal phosphate binding |
C | 0036255 | biological_process | response to methylamine |
C | 0042803 | molecular_function | protein homodimerization activity |
C | 0070280 | molecular_function | pyridoxal binding |
C | 1903442 | biological_process | response to lipoic acid |
C | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
D | 0004375 | molecular_function | glycine dehydrogenase (decarboxylating) activity |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005739 | cellular_component | mitochondrion |
D | 0005759 | cellular_component | mitochondrial matrix |
D | 0005886 | cellular_component | plasma membrane |
D | 0005960 | cellular_component | glycine cleavage complex |
D | 0006520 | biological_process | amino acid metabolic process |
D | 0006544 | biological_process | glycine metabolic process |
D | 0006546 | biological_process | glycine catabolic process |
D | 0009055 | molecular_function | electron transfer activity |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016594 | molecular_function | glycine binding |
D | 0016829 | molecular_function | lyase activity |
D | 0019464 | biological_process | glycine decarboxylation via glycine cleavage system |
D | 0030170 | molecular_function | pyridoxal phosphate binding |
D | 0036255 | biological_process | response to methylamine |
D | 0042803 | molecular_function | protein homodimerization activity |
D | 0070280 | molecular_function | pyridoxal binding |
D | 1903442 | biological_process | response to lipoic acid |
D | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | binding site for residue PLP A 1101 |
Chain | Residue |
A | TYR161 |
A | ASP727 |
A | ALA729 |
A | ASN751 |
A | HIS753 |
A | LYS754 |
A | GOL1106 |
A | HOH1211 |
A | CYS382 |
A | THR383 |
A | SER557 |
A | GLY618 |
A | ALA619 |
A | GLU622 |
A | HIS651 |
A | THR653 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue EDO A 1102 |
Chain | Residue |
A | HIS60 |
A | ARG66 |
A | GLU113 |
A | HOH1377 |
B | EDO1103 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue EDO A 1103 |
Chain | Residue |
A | ARG461 |
A | LEU462 |
A | VAL785 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue EDO A 1104 |
Chain | Residue |
A | ARG103 |
A | LYS106 |
A | GLU604 |
A | ARG739 |
site_id | AC5 |
Number of Residues | 10 |
Details | binding site for residue PEG A 1105 |
Chain | Residue |
A | ASN543 |
A | HIS550 |
A | ASN980 |
A | LYS981 |
A | PHE982 |
A | HOH1349 |
A | HOH1456 |
A | HOH1531 |
A | HOH1549 |
B | ASN543 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue GOL A 1106 |
Chain | Residue |
A | TYR164 |
A | CYS558 |
A | HIS651 |
A | LYS754 |
A | THR894 |
A | PLP1101 |
A | HOH1201 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue GOL A 1107 |
Chain | Residue |
A | ARG51 |
A | GLU54 |
A | LEU57 |
A | PRO58 |
A | ARG59 |
A | HOH1501 |
B | GLU478 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue EDO B 1102 |
Chain | Residue |
B | HIS60 |
B | ARG66 |
B | GLU113 |
B | HOH1379 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue EDO B 1103 |
Chain | Residue |
A | HIS60 |
A | ASP61 |
A | ARG66 |
A | EDO1102 |
B | HIS399 |
B | GLY403 |
B | HIS406 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue EDO B 1104 |
Chain | Residue |
B | HIS399 |
B | HIS402 |
site_id | AD2 |
Number of Residues | 8 |
Details | binding site for residue PEG B 1105 |
Chain | Residue |
A | ASN543 |
A | HOH1531 |
B | ASN980 |
B | LYS981 |
B | PHE982 |
B | TRP983 |
B | HOH1243 |
B | HOH1440 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue EDO C 1102 |
Chain | Residue |
C | ASN140 |
C | CYS141 |
C | LEU297 |
C | ARG319 |
C | ASP473 |
C | GLU474 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue EDO C 1103 |
Chain | Residue |
C | ARG461 |
C | LEU462 |
C | VAL785 |
site_id | AD5 |
Number of Residues | 7 |
Details | binding site for residue EDO C 1104 |
Chain | Residue |
C | GLN208 |
C | ASP375 |
C | ALA377 |
C | SER379 |
C | ALA656 |
C | HIS659 |
C | MET660 |
site_id | AD6 |
Number of Residues | 7 |
Details | binding site for residue PEG C 1105 |
Chain | Residue |
C | ASN543 |
C | ASN980 |
C | LYS981 |
C | PHE982 |
C | HOH1452 |
C | HOH1483 |
D | ASN543 |
site_id | AD7 |
Number of Residues | 10 |
Details | binding site for residue PEG C 1106 |
Chain | Residue |
C | ASN114 |
C | HOH1246 |
C | HOH1324 |
D | SER142 |
D | HIS399 |
D | EDO1103 |
D | HOH1239 |
C | ASP61 |
C | ARG66 |
C | GLU113 |
site_id | AD8 |
Number of Residues | 7 |
Details | binding site for residue GOL C 1107 |
Chain | Residue |
C | ARG51 |
C | GLU54 |
C | LEU57 |
C | ARG59 |
C | HOH1284 |
D | GLU478 |
D | HOH1379 |
site_id | AD9 |
Number of Residues | 9 |
Details | binding site for residue GOL C 1108 |
Chain | Residue |
C | TYR164 |
C | GLY556 |
C | SER557 |
C | CYS558 |
C | HIS651 |
C | LYS754 |
C | THR894 |
C | PLP1101 |
C | HOH1201 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue PEG D 1101 |
Chain | Residue |
C | ASN543 |
D | ASN543 |
D | LYS981 |
D | PHE982 |
D | HOH1336 |
D | HOH1415 |
site_id | AE2 |
Number of Residues | 6 |
Details | binding site for residue EDO D 1103 |
Chain | Residue |
C | HIS60 |
C | ASP61 |
C | ARG66 |
C | PEG1106 |
D | HIS399 |
D | GLY403 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue EDO D 1104 |
Chain | Residue |
D | ASP61 |
D | ARG66 |
D | GLU113 |
D | HOH1289 |
site_id | AE4 |
Number of Residues | 6 |
Details | binding site for residue GOL D 1105 |
Chain | Residue |
D | TYR164 |
D | GLN370 |
D | HIS371 |
D | HIS651 |
D | LYS754 |
D | PLP1102 |
site_id | AE5 |
Number of Residues | 20 |
Details | binding site for Di-peptide PLP B 1101 and LYS B 754 |
Chain | Residue |
B | CYS382 |
B | THR383 |
B | SER557 |
B | CYS558 |
B | THR559 |
B | SER617 |
B | GLY618 |
B | ALA619 |
B | GLU622 |
B | HIS651 |
B | THR653 |
B | ASP727 |
B | ALA729 |
B | ASN751 |
B | LEU752 |
B | HIS753 |
B | THR755 |
B | PHE756 |
B | HOH1206 |
B | HOH1410 |
site_id | AE6 |
Number of Residues | 21 |
Details | binding site for Di-peptide PLP C 1101 and LYS C 754 |
Chain | Residue |
C | CYS382 |
C | THR383 |
C | SER557 |
C | CYS558 |
C | THR559 |
C | SER617 |
C | GLY618 |
C | ALA619 |
C | GLU622 |
C | HIS651 |
C | THR653 |
C | ASP727 |
C | ALA729 |
C | ASN751 |
C | LEU752 |
C | HIS753 |
C | THR755 |
C | PHE756 |
C | GOL1108 |
C | HOH1237 |
C | HOH1509 |
site_id | AE7 |
Number of Residues | 21 |
Details | binding site for Di-peptide PLP D 1102 and LYS D 754 |
Chain | Residue |
D | CYS382 |
D | THR383 |
D | SER557 |
D | CYS558 |
D | THR559 |
D | SER617 |
D | GLY618 |
D | ALA619 |
D | GLU622 |
D | HIS651 |
D | THR653 |
D | ASP727 |
D | ALA729 |
D | ASN751 |
D | LEU752 |
D | HIS753 |
D | THR755 |
D | PHE756 |
D | GOL1105 |
D | HOH1249 |
D | HOH1429 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q91W43 |
Chain | Residue | Details |
A | LYS447 | |
A | LYS514 | |
A | LYS648 | |
A | LYS664 | |
B | LYS447 | |
B | LYS514 | |
B | LYS648 | |
B | LYS664 | |
C | LYS447 | |
C | LYS514 | |
C | LYS648 | |
C | LYS664 | |
D | LYS447 | |
D | LYS514 | |
D | LYS648 | |
D | LYS664 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250|UniProtKB:P15505 |
Chain | Residue | Details |
A | LYS754 | |
B | LYS754 | |
C | LYS754 | |
D | LYS754 |