Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HZW

THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL 2.22 resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ACT A 401

Chain	Residue
A	ARG77
A	ILE131
A	GLU181
E	PHE42
E	ARG105

site_id	AC2
Number of Residues	6
Details	binding site for residue PLC A 402

Chain	Residue
A	PHE315
A	PLC403
A	ARG118
A	TYR194
A	TYR254
A	ASN307

site_id	AC3
Number of Residues	1
Details	binding site for residue PLC A 403

Chain	Residue
A	PLC402

site_id	AC4
Number of Residues	4
Details	binding site for residue CL A 404

Chain	Residue
A	PHE78
A	ARG85
A	HOH570
A	HOH594

site_id	AC5
Number of Residues	4
Details	binding site for residue CL A 405

Chain	Residue
A	ASN139
A	LEU180
D	ALA175
D	HOH573

site_id	AC6
Number of Residues	2
Details	binding site for residue CL A 406

Chain	Residue
A	ALA175
D	LEU180

site_id	AC7
Number of Residues	2
Details	binding site for residue NA A 407

Chain	Residue
A	PRO68
A	ILE71

site_id	AC8
Number of Residues	4
Details	binding site for residue ACT A 408

Chain	Residue
A	ILE73
A	PRO74
A	ILE76
A	ARG85

site_id	AC9
Number of Residues	3
Details	binding site for residue LMT A 411

Chain	Residue
A	ARG118
A	LEU313
A	PHE314

site_id	AD1
Number of Residues	6
Details	binding site for residue PLC A 412

Chain	Residue
A	VAL275
A	TYR278
A	GLU282
A	GLN284
A	ARG287
E	TRP217

site_id	AD2
Number of Residues	6
Details	binding site for residue PLC B 401

Chain	Residue
A	TRP217
B	THR274
B	VAL275
B	GLU282
B	GLN284
B	ARG287

site_id	AD3
Number of Residues	5
Details	binding site for residue ACT B 402

Chain	Residue
A	PHE42
A	ARG105
B	ARG77
B	ILE131
B	GLU181

site_id	AD4
Number of Residues	7
Details	binding site for residue PLC B 403

Chain	Residue
B	ARG118
B	PHE121
B	TYR194
B	TYR254
B	ILE258
B	ASN307
B	PHE315

site_id	AD5
Number of Residues	3
Details	binding site for residue CL B 405

Chain	Residue
B	PHE78
B	ARG85
B	HOH595

site_id	AD6
Number of Residues	2
Details	binding site for residue NA B 406

Chain	Residue
B	PRO68
B	ILE71

site_id	AD7
Number of Residues	4
Details	binding site for residue ACT B 407

Chain	Residue
B	PRO74
B	ILE76
B	ARG85
B	TYR102

site_id	AD8
Number of Residues	4
Details	binding site for residue LMT B 409

Chain	Residue
B	ARG118
B	MET261
B	LEU313
B	PHE314

site_id	AD9
Number of Residues	1
Details	binding site for residue NA C 401

Chain	Residue
C	THR226

site_id	AE1
Number of Residues	6
Details	binding site for residue PLC C 402

Chain	Residue
B	TRP217
C	VAL275
C	TYR278
C	GLU282
C	GLN284
C	ARG287

site_id	AE2
Number of Residues	5
Details	binding site for residue ACT C 403

Chain	Residue
B	PHE42
B	ARG105
C	ARG77
C	ILE131
C	GLU181

site_id	AE3
Number of Residues	5
Details	binding site for residue PLC C 404

Chain	Residue
C	PHE121
C	TYR194
C	TYR254
C	ASN307
C	PHE315

site_id	AE4
Number of Residues	3
Details	binding site for residue CL C 406

Chain	Residue
C	PHE78
C	ARG85
C	HOH577

site_id	AE5
Number of Residues	2
Details	binding site for residue NA C 407

Chain	Residue
C	PRO68
C	ILE71

site_id	AE6
Number of Residues	5
Details	binding site for residue ACT C 408

Chain	Residue
C	ILE73
C	PRO74
C	ILE76
C	ARG85
C	TYR102

site_id	AE7
Number of Residues	4
Details	binding site for residue LMT C 410

Chain	Residue
C	ARG118
C	LEU313
C	PHE314
C	HOH514

site_id	AE8
Number of Residues	5
Details	binding site for residue PLC D 401

Chain	Residue
C	TRP217
D	TYR278
D	GLU282
D	GLN284
D	ARG287

site_id	AE9
Number of Residues	5
Details	binding site for residue ACT D 402

Chain	Residue
C	PHE42
C	ARG105
D	ARG77
D	ILE131
D	GLU181

site_id	AF1
Number of Residues	4
Details	binding site for residue PLC D 403

Chain	Residue
D	ARG118
D	TYR194
D	TYR254
D	PHE315

site_id	AF2
Number of Residues	3
Details	binding site for residue CL D 405

Chain	Residue
D	PHE78
D	ARG85
D	HOH581

site_id	AF3
Number of Residues	3
Details	binding site for residue NA D 406

Chain	Residue
D	PRO68
D	ILE71
D	ILE73

site_id	AF4
Number of Residues	5
Details	binding site for residue ACT D 407

Chain	Residue
D	ILE73
D	PRO74
D	ILE76
D	ARG85
D	TYR102

site_id	AF5
Number of Residues	1
Details	binding site for residue LMT D 408

Chain	Residue
D	ALA237

site_id	AF6
Number of Residues	2
Details	binding site for residue LMT D 409

Chain	Residue
D	ARG118
D	LEU313

site_id	AF7
Number of Residues	5
Details	binding site for residue PLC E 401

Chain	Residue
D	TRP217
E	TYR278
E	GLU282
E	GLN284
E	ARG287

site_id	AF8
Number of Residues	5
Details	binding site for residue ACT E 402

Chain	Residue
D	PHE42
D	ARG105
E	ARG77
E	ILE131
E	GLU181

site_id	AF9
Number of Residues	5
Details	binding site for residue PLC E 403

Chain	Residue
E	ARG118
E	TYR194
E	TYR254
E	ASN307
E	PHE315

site_id	AG1
Number of Residues	3
Details	binding site for residue CL E 405

Chain	Residue
E	PHE78
E	ARG85
E	HOH578

site_id	AG2
Number of Residues	2
Details	binding site for residue NA E 406

Chain	Residue
E	PRO68
E	ILE71

site_id	AG3
Number of Residues	4
Details	binding site for residue ACT E 407

Chain	Residue
E	PRO74
E	ILE76
E	ARG85
E	TYR102

site_id	AG4
Number of Residues	3
Details	binding site for residue LMT E 409

Chain	Residue
E	ARG118
E	LEU313
E	PHE314

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	990
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN2-GLN193
E	ASN245-MET252
A	ASN245-MET252
B	GLN2-GLN193
B	ASN245-MET252
C	GLN2-GLN193
C	ASN245-MET252
D	GLN2-GLN193
D	ASN245-MET252
E	GLN2-GLN193

site_id	SWS_FT_FI2
Number of Residues	530
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR194-PHE216
C	SER220-THR244
C	THR253-VAL281
C	PRO285-PHE317
D	TYR194-PHE216
D	SER220-THR244
D	THR253-VAL281
D	PRO285-PHE317
E	TYR194-PHE216
E	SER220-THR244
E	THR253-VAL281
A	SER220-THR244
E	PRO285-PHE317
A	THR253-VAL281
A	PRO285-PHE317
B	TYR194-PHE216
B	SER220-THR244
B	THR253-VAL281
B	PRO285-PHE317
C	TYR194-PHE216

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP217-THR219
E	GLU282-GLN284
A	GLU282-GLN284
B	TRP217-THR219
B	GLU282-GLN284
C	TRP217-THR219
C	GLU282-GLN284
D	TRP217-THR219
D	GLU282-GLN284
E	TRP217-THR219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)