6HZ1
THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 1902495 | cellular_component | transmembrane transporter complex |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005272 | molecular_function | sodium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 1902495 | cellular_component | transmembrane transporter complex |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0005267 | molecular_function | potassium channel activity |
| C | 0005272 | molecular_function | sodium channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006814 | biological_process | sodium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0035725 | biological_process | sodium ion transmembrane transport |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0071805 | biological_process | potassium ion transmembrane transport |
| C | 1902495 | cellular_component | transmembrane transporter complex |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0005267 | molecular_function | potassium channel activity |
| D | 0005272 | molecular_function | sodium channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006814 | biological_process | sodium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0035725 | biological_process | sodium ion transmembrane transport |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0071805 | biological_process | potassium ion transmembrane transport |
| D | 1902495 | cellular_component | transmembrane transporter complex |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0005267 | molecular_function | potassium channel activity |
| E | 0005272 | molecular_function | sodium channel activity |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0006814 | biological_process | sodium ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0035725 | biological_process | sodium ion transmembrane transport |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0071805 | biological_process | potassium ion transmembrane transport |
| E | 1902495 | cellular_component | transmembrane transporter complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 401 |
| Chain | Residue |
| A | ARG77 |
| A | ILE131 |
| A | GLU181 |
| E | PHE42 |
| E | ARG105 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PLC A 402 |
| Chain | Residue |
| A | PHE315 |
| A | PLC403 |
| A | ARG118 |
| A | PHE121 |
| A | TYR254 |
| A | ASN307 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue PLC A 403 |
| Chain | Residue |
| A | PLC402 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 404 |
| Chain | Residue |
| A | PHE78 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 405 |
| Chain | Residue |
| A | ASN139 |
| A | LEU180 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 406 |
| Chain | Residue |
| A | ALA175 |
| D | ASN139 |
| D | LEU180 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 407 |
| Chain | Residue |
| A | PRO68 |
| A | ILE71 |
| A | TRP72 |
| A | ILE73 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 409 |
| Chain | Residue |
| A | ILE73 |
| A | PRO74 |
| A | ILE76 |
| A | ARG85 |
| A | TYR102 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue LMT A 411 |
| Chain | Residue |
| B | THR244 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue PLC A 412 |
| Chain | Residue |
| E | PHE210 |
| E | TRP217 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue PLC B 401 |
| Chain | Residue |
| A | PHE210 |
| A | TRP217 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 402 |
| Chain | Residue |
| A | PHE42 |
| A | ARG105 |
| B | ARG77 |
| B | ILE131 |
| B | GLU181 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue PLC B 403 |
| Chain | Residue |
| B | ARG118 |
| B | PHE121 |
| B | TYR254 |
| B | ASN307 |
| B | PHE315 |
| B | PLC404 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue PLC B 404 |
| Chain | Residue |
| B | PLC403 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 405 |
| Chain | Residue |
| B | PHE78 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue NA B 406 |
| Chain | Residue |
| B | PRO68 |
| B | ILE71 |
| B | ILE73 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 407 |
| Chain | Residue |
| B | ILE73 |
| B | PRO74 |
| B | ILE76 |
| B | ARG85 |
| B | TYR102 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue LMT B 408 |
| Chain | Residue |
| B | LEU241 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 409 |
| Chain | Residue |
| B | PHE42 |
| B | ARG105 |
| C | ARG77 |
| C | ILE131 |
| C | GLU181 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue PLC C 401 |
| Chain | Residue |
| B | PHE210 |
| B | TRP217 |
| C | TYR278 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue PLC C 402 |
| Chain | Residue |
| C | ARG118 |
| C | PHE121 |
| C | TYR254 |
| C | ASN307 |
| C | PHE315 |
| C | PLC403 |
| site_id | AE4 |
| Number of Residues | 1 |
| Details | binding site for residue PLC C 403 |
| Chain | Residue |
| C | PLC402 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 404 |
| Chain | Residue |
| C | PHE78 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue NA C 405 |
| Chain | Residue |
| C | PRO68 |
| C | ILE71 |
| C | ILE73 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue ACT C 406 |
| Chain | Residue |
| C | ILE73 |
| C | PRO74 |
| C | ILE76 |
| C | ARG85 |
| C | TYR102 |
| site_id | AE8 |
| Number of Residues | 1 |
| Details | binding site for residue LMT C 407 |
| Chain | Residue |
| B | ALA237 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue ACT C 408 |
| Chain | Residue |
| C | PHE42 |
| C | ARG105 |
| D | ARG77 |
| D | ILE131 |
| D | GLU181 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue PLC D 401 |
| Chain | Residue |
| C | PHE210 |
| C | TRP217 |
| D | TYR278 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue PLC D 402 |
| Chain | Residue |
| D | ARG118 |
| D | PHE121 |
| D | TYR254 |
| D | ASN307 |
| D | PHE315 |
| D | PLC403 |
| site_id | AF3 |
| Number of Residues | 1 |
| Details | binding site for residue PLC D 403 |
| Chain | Residue |
| D | PLC402 |
| site_id | AF4 |
| Number of Residues | 1 |
| Details | binding site for residue CL D 404 |
| Chain | Residue |
| D | PHE78 |
| site_id | AF5 |
| Number of Residues | 3 |
| Details | binding site for residue NA D 405 |
| Chain | Residue |
| D | PRO68 |
| D | ILE71 |
| D | ILE73 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT D 406 |
| Chain | Residue |
| D | PRO74 |
| D | ILE76 |
| D | ARG85 |
| D | TYR102 |
| D | ILE73 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue LMT D 407 |
| Chain | Residue |
| C | ALA237 |
| D | ALA237 |
| D | LMT408 |
| site_id | AF8 |
| Number of Residues | 3 |
| Details | binding site for residue LMT D 408 |
| Chain | Residue |
| D | ALA237 |
| D | LMT407 |
| E | ILE240 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue PLC E 401 |
| Chain | Residue |
| D | PHE210 |
| D | TRP217 |
| E | TYR278 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue ACT E 402 |
| Chain | Residue |
| D | PHE42 |
| D | ARG105 |
| E | ARG77 |
| E | ILE131 |
| E | GLU181 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue PLC E 403 |
| Chain | Residue |
| E | ARG118 |
| E | PHE121 |
| E | TYR254 |
| E | ASN307 |
| E | PHE315 |
| E | PLC404 |
| site_id | AG3 |
| Number of Residues | 1 |
| Details | binding site for residue PLC E 404 |
| Chain | Residue |
| E | PLC403 |
| site_id | AG4 |
| Number of Residues | 1 |
| Details | binding site for residue CL E 405 |
| Chain | Residue |
| E | PHE78 |
| site_id | AG5 |
| Number of Residues | 3 |
| Details | binding site for residue NA E 406 |
| Chain | Residue |
| E | PRO68 |
| E | ILE71 |
| E | ILE73 |
| site_id | AG6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT E 407 |
| Chain | Residue |
| E | ILE73 |
| E | PRO74 |
| E | ILE76 |
| E | ARG85 |
| E | TYR102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 990 |
| Details | TOPO_DOM: Periplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN2-GLN193 | |
| E | ASN245-MET252 | |
| A | ASN245-MET252 | |
| B | GLN2-GLN193 | |
| B | ASN245-MET252 | |
| C | GLN2-GLN193 | |
| C | ASN245-MET252 | |
| D | GLN2-GLN193 | |
| D | ASN245-MET252 | |
| E | GLN2-GLN193 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 530 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | TYR194-PHE216 | |
| C | SER220-THR244 | |
| C | THR253-VAL281 | |
| C | PRO285-PHE317 | |
| D | TYR194-PHE216 | |
| D | SER220-THR244 | |
| D | THR253-VAL281 | |
| D | PRO285-PHE317 | |
| E | TYR194-PHE216 | |
| E | SER220-THR244 | |
| E | THR253-VAL281 | |
| A | SER220-THR244 | |
| E | PRO285-PHE317 | |
| A | THR253-VAL281 | |
| A | PRO285-PHE317 | |
| B | TYR194-PHE216 | |
| B | SER220-THR244 | |
| B | THR253-VAL281 | |
| B | PRO285-PHE317 | |
| C | TYR194-PHE216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | TRP217-THR219 | |
| E | GLU282-GLN284 | |
| A | GLU282-GLN284 | |
| B | TRP217-THR219 | |
| B | GLU282-GLN284 | |
| C | TRP217-THR219 | |
| C | GLU282-GLN284 | |
| D | TRP217-THR219 | |
| D | GLU282-GLN284 | |
| E | TRP217-THR219 |
