Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HYR

THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193C+MMTS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
A	1902495	cellular_component	transmembrane transporter complex
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
B	1902495	cellular_component	transmembrane transporter complex
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
C	1902495	cellular_component	transmembrane transporter complex
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
D	1902495	cellular_component	transmembrane transporter complex
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport
E	1902495	cellular_component	transmembrane transporter complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for Di-peptide ARG B 192 and SCH B 193

Chain	Residue
B	ASP32
B	PHE195
B	TYR119
B	PRO120
B	ASP122
B	GLY159
B	TRP160
B	ASP161
B	SER191
B	TYR194

site_id	AC2
Number of Residues	11
Details	binding site for Di-peptide SCH B 193 and TYR B 194

Chain	Residue
B	TYR119
B	GLY159
B	ASP161
B	SER191
B	ARG192
B	PHE195
B	SER196
B	TYR197
B	ILE201
B	ASN245
C	PRO250

site_id	AC3
Number of Residues	11
Details	binding site for Di-peptide ARG C 192 and SCH C 193

Chain	Residue
C	ASP32
C	PHE116
C	TYR119
C	PRO120
C	ASP122
C	GLY159
C	TRP160
C	ASP161
C	SER191
C	TYR194
C	PHE195

site_id	AC4
Number of Residues	11
Details	binding site for Di-peptide SCH C 193 and TYR C 194

Chain	Residue
C	TYR119
C	GLY159
C	ASP161
C	SER191
C	ARG192
C	PHE195
C	SER196
C	TYR197
C	ILE201
C	ASN245
D	PRO250

site_id	AC5
Number of Residues	10
Details	binding site for Di-peptide ARG D 192 and SCH D 193

Chain	Residue
D	ASP32
D	TYR119
D	PRO120
D	ASP122
D	GLY159
D	TRP160
D	ASP161
D	SER191
D	TYR194
D	PHE195

site_id	AC6
Number of Residues	11
Details	binding site for Di-peptide SCH D 193 and TYR D 194

Chain	Residue
D	TYR119
D	GLY159
D	ASP161
D	SER191
D	ARG192
D	PHE195
D	SER196
D	TYR197
D	ILE201
D	ASN245
E	PRO250

site_id	AC7
Number of Residues	11
Details	binding site for Di-peptide ARG E 192 and SCH E 193

Chain	Residue
A	PRO250
E	ASP32
E	TYR119
E	PRO120
E	ASP122
E	GLY159
E	TRP160
E	ASP161
E	SER191
E	TYR194
E	PHE195

site_id	AC8
Number of Residues	12
Details	binding site for Di-peptide SCH E 193 and TYR E 194

Chain	Residue
A	THR249
A	PRO250
E	TYR119
E	GLY159
E	ASP161
E	SER191
E	ARG192
E	PHE195
E	SER196
E	TYR197
E	ILE201
E	ASN245

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR194-PHE216
D	TYR194-PHE216
D	SER220-THR244
D	THR253-VAL281
E	TYR194-PHE216
E	SER220-THR244
E	THR253-VAL281
A	SER220-THR244
A	THR253-VAL281
B	TYR194-PHE216
B	SER220-THR244
B	THR253-VAL281
C	TYR194-PHE216
C	SER220-THR244
C	THR253-VAL281

site_id	SWS_FT_FI2
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP217-THR219
E	GLU282-GLN284
A	GLU282-GLN284
B	TRP217-THR219
B	GLU282-GLN284
C	TRP217-THR219
C	GLU282-GLN284
D	TRP217-THR219
D	GLU282-GLN284
E	TRP217-THR219

site_id	SWS_FT_FI3
Number of Residues	35
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	ASN245-MET252
B	ASN245-MET252
C	ASN245-MET252
D	ASN245-MET252
E	ASN245-MET252

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)