6HYQ
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi bound to guanosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001932 | biological_process | regulation of protein phosphorylation |
| A | 0005952 | cellular_component | cAMP-dependent protein kinase complex |
| A | 0008603 | molecular_function | cAMP-dependent protein kinase regulator activity |
| B | 0001932 | biological_process | regulation of protein phosphorylation |
| B | 0005952 | cellular_component | cAMP-dependent protein kinase complex |
| B | 0008603 | molecular_function | cAMP-dependent protein kinase regulator activity |
| C | 0001932 | biological_process | regulation of protein phosphorylation |
| C | 0005952 | cellular_component | cAMP-dependent protein kinase complex |
| C | 0008603 | molecular_function | cAMP-dependent protein kinase regulator activity |
| D | 0001932 | biological_process | regulation of protein phosphorylation |
| D | 0005952 | cellular_component | cAMP-dependent protein kinase complex |
| D | 0008603 | molecular_function | cAMP-dependent protein kinase regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue GMP A 601 |
| Chain | Residue |
| A | MET272 |
| A | GLU312 |
| A | VAL320 |
| A | ALA321 |
| A | TYR371 |
| A | ILE292 |
| A | TYR300 |
| A | LYS302 |
| A | ALA307 |
| A | VAL308 |
| A | GLY309 |
| A | GLU310 |
| A | LEU311 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue GMP A 602 |
| Chain | Residue |
| A | VAL411 |
| A | CYS424 |
| A | PHE426 |
| A | ILE432 |
| A | GLY433 |
| A | GLU434 |
| A | LEU435 |
| A | GLU436 |
| A | VAL444 |
| A | ALA445 |
| A | VAL447 |
| A | LYS482 |
| A | TYR483 |
| A | TYR485 |
| A | TYR486 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue GMP B 601 |
| Chain | Residue |
| B | MET272 |
| B | ILE292 |
| B | LYS294 |
| B | TYR300 |
| B | LYS302 |
| B | ALA307 |
| B | VAL308 |
| B | GLY309 |
| B | GLU310 |
| B | LEU311 |
| B | GLU312 |
| B | VAL319 |
| B | VAL320 |
| B | ALA321 |
| B | TYR371 |
| B | HOH703 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue GMP B 602 |
| Chain | Residue |
| B | VAL411 |
| B | VAL423 |
| B | CYS424 |
| B | PHE426 |
| B | ILE432 |
| B | GLY433 |
| B | GLU434 |
| B | LEU435 |
| B | GLU436 |
| B | VAL444 |
| B | ALA445 |
| B | VAL447 |
| B | LYS482 |
| B | TYR483 |
| B | TYR485 |
| B | TYR486 |
| B | HOH713 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 603 |
| Chain | Residue |
| B | GLU397 |
| B | TYR499 |
| B | VAL500 |
| B | ASP501 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue GMP C 601 |
| Chain | Residue |
| C | ILE292 |
| C | LYS294 |
| C | TYR300 |
| C | LYS302 |
| C | ALA307 |
| C | VAL308 |
| C | GLY309 |
| C | GLU310 |
| C | LEU311 |
| C | GLU312 |
| C | VAL320 |
| C | ALA321 |
| C | TYR371 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue GMP C 602 |
| Chain | Residue |
| C | VAL411 |
| C | VAL423 |
| C | CYS424 |
| C | PHE426 |
| C | ILE432 |
| C | GLY433 |
| C | GLU434 |
| C | LEU435 |
| C | GLU436 |
| C | VAL444 |
| C | ALA445 |
| C | VAL447 |
| C | LYS482 |
| C | TYR483 |
| C | TYR485 |
| C | TYR486 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue GMP D 601 |
| Chain | Residue |
| D | ALA307 |
| D | VAL308 |
| D | GLY309 |
| D | GLU310 |
| D | LEU311 |
| D | GLU312 |
| D | VAL320 |
| D | ALA321 |
| D | TYR371 |
| D | HOH730 |
| D | MET272 |
| D | ILE292 |
| D | LYS294 |
| D | TYR300 |
| D | LYS302 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | binding site for residue GMP D 602 |
| Chain | Residue |
| D | VAL411 |
| D | VAL423 |
| D | CYS424 |
| D | PHE426 |
| D | ILE432 |
| D | GLY433 |
| D | GLU434 |
| D | LEU435 |
| D | GLU436 |
| D | VAL444 |
| D | ALA445 |
| D | VAL447 |
| D | LYS482 |
| D | TYR483 |
| D | TYR485 |
| D | TYR486 |
| D | HOH707 |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIhYGEeGEwLYIImeG |
| Chain | Residue | Details |
| A | ILE391-GLY407 |
