6HY1

Plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and N,N'-Bis(3-aminopropyl)-1,4-cyclohexanediamine after catalysis in crystal

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity
C	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue GXQ A 401

Chain	Residue
A	TRP51
A	GLN229
A	GLU231
A	TYR264
A	MTA402
A	HOH550
A	ILE92
A	GLN93
A	TYR102
A	HIS103
A	ASP127
A	ASP196
A	SER197
A	ASP199

---

site_id	AC2
Number of Residues	18
Details	binding site for residue MTA A 402

Chain	Residue
A	GLN72
A	GLN93
A	GLY124
A	GLY125
A	ASP127
A	CYS146
A	GLU147
A	ILE148
A	VAL152
A	ASP178
A	ALA179
A	ASP196
A	SER198
A	PRO203
A	ALA204
A	THR206
A	LEU207
A	GXQ401

---

site_id	AC3
Number of Residues	9
Details	binding site for residue 1PG A 403

Chain	Residue
A	TRP43
A	TRP43
A	SER45
A	SER45
A	PHE47
A	PHE47
A	SER57
A	HOH511
A	HOH511

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 404

Chain	Residue
A	LYS97
A	PHE100
A	TRP234
A	HOH577

---

site_id	AC5
Number of Residues	16
Details	binding site for residue GXQ B 401

Chain	Residue
B	ILE92
B	GLN93
B	TYR102
B	HIS103
B	ASP127
B	ASP196
B	SER197
B	ASP199
B	GLU231
B	SER232
B	TYR264
B	ILE269
B	MTA402
B	HOH503
B	HOH559
B	HOH577

---

site_id	AC6
Number of Residues	19
Details	binding site for residue MTA B 402

Chain	Residue
B	GLN72
B	GLY124
B	GLY125
B	ASP127
B	CYS146
B	GLU147
B	ILE148
B	VAL152
B	GLU177
B	ASP178
B	ALA179
B	ASP196
B	SER197
B	SER198
B	PRO203
B	ALA204
B	THR206
B	LEU207
B	GXQ401

---

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL B 403

Chain	Residue
B	LYS97
B	LYS297
B	HOH543
B	HOH565
B	HOH575
C	TRP234

---

site_id	AC8
Number of Residues	5
Details	binding site for residue 1PG B 404

Chain	Residue
B	PHE47
B	SER57
C	TRP43
C	PHE47
C	SER57

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL B 405

Chain	Residue
B	LYS286
B	LYS287
B	GLU289
B	SER290
B	PHE293

---

site_id	AD1
Number of Residues	4
Details	binding site for residue GOL B 406

Chain	Residue
B	LYS291
B	HIS236
B	VAL237
B	GLY238

---

site_id	AD2
Number of Residues	14
Details	binding site for residue JFQ C 401

Chain	Residue
C	ILE92
C	GLN93
C	TYR102
C	HIS103
C	ASP127
C	ASP196
C	SER197
C	ASP199
C	GLN229
C	TYR264
C	ILE269
C	MTA402
C	HOH562
C	HOH594

---

site_id	AD3
Number of Residues	21
Details	binding site for residue MTA C 402

Chain	Residue
C	GLN72
C	GLN93
C	GLY124
C	GLY125
C	ASP127
C	CYS146
C	GLU147
C	ILE148
C	ASP149
C	VAL152
C	GLU177
C	ASP178
C	ALA179
C	ASP196
C	SER197
C	SER198
C	PRO203
C	ALA204
C	THR206
C	LEU207
C	JFQ401

---

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL C 403

Chain	Residue
B	TRP234
C	LYS97
C	LYS297
C	HOH522
C	HOH549
C	HOH584
C	HOH598

---

site_id	AD5
Number of Residues	5
Details	binding site for residue GOL C 404

Chain	Residue
C	PHE208
C	THR239
C	ASN242
C	TYR246
C	HOH645

---

site_id	AD6
Number of Residues	10
Details	binding site for residue GOL C 405

Chain	Residue
B	PHE56
B	PRO262
B	CYS266
C	PRO262
C	PRO265
C	CYS266
C	GLY267
C	HOH540
C	HOH629
C	HOH639

---

Functional Information from PROSITE/UniProt

site_id	PS01330
Number of Residues	14
Details	PABS_1 Polyamine biosynthesis (PABS) domain signature. VLVVGGGdGgiIrE

Chain	Residue	Details
A	VAL120-GLU133

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