6HXU
Crystal structure of Human RHOB Q63L in complex with GTP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000281 | biological_process | mitotic cytokinesis |
| A | 0001525 | biological_process | angiogenesis |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005768 | cellular_component | endosome |
| A | 0005769 | cellular_component | early endosome |
| A | 0005770 | cellular_component | late endosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007015 | biological_process | actin filament organization |
| A | 0007155 | biological_process | cell adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0007266 | biological_process | Rho protein signal transduction |
| A | 0008333 | biological_process | endosome to lysosome transport |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010595 | biological_process | positive regulation of endothelial cell migration |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0019003 | molecular_function | GDP binding |
| A | 0030154 | biological_process | cell differentiation |
| A | 0030334 | biological_process | regulation of cell migration |
| A | 0030335 | biological_process | positive regulation of cell migration |
| A | 0030336 | biological_process | negative regulation of cell migration |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0032154 | cellular_component | cleavage furrow |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0045202 | cellular_component | synapse |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0045786 | biological_process | negative regulation of cell cycle |
| A | 0061154 | biological_process | endothelial tube morphogenesis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070301 | biological_process | cellular response to hydrogen peroxide |
| A | 0071479 | biological_process | cellular response to ionizing radiation |
| A | 0098685 | cellular_component | Schaffer collateral - CA1 synapse |
| A | 0099159 | biological_process | regulation of modification of postsynaptic structure |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | binding site for residue GTP A 201 |
| Chain | Residue |
| A | GLY14 |
| A | PRO36 |
| A | THR37 |
| A | GLY62 |
| A | LYS118 |
| A | ASP120 |
| A | LEU121 |
| A | SER160 |
| A | ALA161 |
| A | LYS162 |
| A | TYR183 |
| A | ALA15 |
| A | MG202 |
| A | HOH323 |
| A | HOH343 |
| A | HOH359 |
| A | HOH365 |
| A | HOH375 |
| A | HOH383 |
| A | HOH386 |
| A | HOH406 |
| A | HOH456 |
| A | CYS16 |
| A | HOH458 |
| A | HOH468 |
| A | GLY17 |
| A | LYS18 |
| A | THR19 |
| A | CYS20 |
| A | PHE30 |
| A | TYR34 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | THR19 |
| A | THR37 |
| A | GTP201 |
| A | HOH323 |
| A | HOH375 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 203 |
| Chain | Residue |
| A | ASN94 |
| A | GLU97 |
| A | HOH335 |
| A | HOH338 |
| A | HOH354 |
| A | HOH457 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylasparagine; by botulinum toxin","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62746","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
