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6HXU

Crystal structure of Human RHOB Q63L in complex with GTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000281biological_processmitotic cytokinesis
A0001525biological_processangiogenesis
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006886biological_processintracellular protein transport
A0006915biological_processapoptotic process
A0007015biological_processactin filament organization
A0007155biological_processcell adhesion
A0007165biological_processsignal transduction
A0007264biological_processsmall GTPase-mediated signal transduction
A0007266biological_processRho protein signal transduction
A0008333biological_processendosome to lysosome transport
A0010008cellular_componentendosome membrane
A0010595biological_processpositive regulation of endothelial cell migration
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0019003molecular_functionGDP binding
A0019901molecular_functionprotein kinase binding
A0030154biological_processcell differentiation
A0030334biological_processregulation of cell migration
A0030336biological_processnegative regulation of cell migration
A0031902cellular_componentlate endosome membrane
A0032154cellular_componentcleavage furrow
A0043065biological_processpositive regulation of apoptotic process
A0045766biological_processpositive regulation of angiogenesis
A0045786biological_processnegative regulation of cell cycle
A0061154biological_processendothelial tube morphogenesis
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0071479biological_processcellular response to ionizing radiation
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0099159biological_processregulation of modification of postsynaptic structure
Functional Information from PDB Data
site_idAC1
Number of Residues31
Detailsbinding site for residue GTP A 201
ChainResidue
AGLY14
APRO36
ATHR37
AGLY62
ALYS118
AASP120
ALEU121
ASER160
AALA161
ALYS162
ATYR183
AALA15
AMG202
AHOH323
AHOH343
AHOH359
AHOH365
AHOH375
AHOH383
AHOH386
AHOH406
AHOH456
ACYS16
AHOH458
AHOH468
AGLY17
ALYS18
ATHR19
ACYS20
APHE30
ATYR34

site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 202
ChainResidue
ATHR19
ATHR37
AGTP201
AHOH323
AHOH375

site_idAC3
Number of Residues6
Detailsbinding site for residue MG A 203
ChainResidue
AASN94
AGLU97
AHOH335
AHOH338
AHOH354
AHOH457

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY12
AASP59
AASN117

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: ADP-ribosylasparagine; by botulinum toxin => ECO:0000250
ChainResidueDetails
AASN41

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62746
ChainResidueDetails
ATYR154

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR34

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB => ECO:0000269|PubMed:24905543
ChainResidueDetails
ATHR37

218853

PDB entries from 2024-04-24

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