6HXM
Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH in space group C2221
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue COA B 1200 |
| Chain | Residue |
| B | ALA938 |
| B | LYS1017 |
| B | LYS1018 |
| B | ASN1020 |
| B | LEU1021 |
| B | ASN1024 |
| B | ASP1026 |
| B | HOH1328 |
| B | HOH1377 |
| B | HOH1396 |
| B | HOH1418 |
| B | LYS964 |
| B | HOH1442 |
| B | HOH1460 |
| B | HOH1469 |
| B | HOH1514 |
| B | LYS965 |
| B | LEU969 |
| B | ILE970 |
| B | MET971 |
| B | GLY972 |
| B | ILE973 |
| B | GLY974 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue FLC B 1201 |
| Chain | Residue |
| B | HIS900 |
| B | VAL904 |
| B | PHE935 |
| B | GLY936 |
| B | ASP1026 |
| B | PHE1061 |
| B | ARG1065 |
| B | ARG1085 |
| B | HOH1301 |
| B | HOH1355 |
| B | HOH1402 |
| B | HOH1410 |
| B | HOH1469 |
| site_id | AC3 |
| Number of Residues | 37 |
| Details | binding site for residues COA A 1200 and FLC A 1201 |
| Chain | Residue |
| A | HIS900 |
| A | VAL904 |
| A | ASP933 |
| A | ARG934 |
| A | PHE935 |
| A | GLY936 |
| A | ALA938 |
| A | LYS964 |
| A | LEU969 |
| A | ILE970 |
| A | GLY972 |
| A | ILE973 |
| A | GLY974 |
| A | HIS975 |
| A | ARG976 |
| A | ARG986 |
| A | ASN1020 |
| A | LEU1021 |
| A | ASN1024 |
| A | VAL1025 |
| A | ASP1026 |
| A | ARG1065 |
| A | ARG1085 |
| A | HOH1303 |
| A | HOH1305 |
| A | HOH1307 |
| A | HOH1311 |
| A | HOH1337 |
| A | HOH1349 |
| A | HOH1352 |
| A | HOH1356 |
| A | HOH1358 |
| A | HOH1385 |
| A | HOH1399 |
| A | HOH1403 |
| A | HOH1417 |
| A | HOH1460 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91V92","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
