Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HXG

PDX1.2/PDX1.3 complex (intermediate)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0042819	biological_process	vitamin B6 biosynthetic process
A	0042823	biological_process	pyridoxal phosphate biosynthetic process
A	0046982	molecular_function	protein heterodimerization activity
B	0042819	biological_process	vitamin B6 biosynthetic process
B	0042823	biological_process	pyridoxal phosphate biosynthetic process
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0042819	biological_process	vitamin B6 biosynthetic process
C	0042823	biological_process	pyridoxal phosphate biosynthetic process
C	0046982	molecular_function	protein heterodimerization activity
D	0042819	biological_process	vitamin B6 biosynthetic process
D	0042823	biological_process	pyridoxal phosphate biosynthetic process
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0042819	biological_process	vitamin B6 biosynthetic process
E	0042823	biological_process	pyridoxal phosphate biosynthetic process
E	0046982	molecular_function	protein heterodimerization activity
F	0042819	biological_process	vitamin B6 biosynthetic process
F	0042823	biological_process	pyridoxal phosphate biosynthetic process
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0042819	biological_process	vitamin B6 biosynthetic process
G	0042823	biological_process	pyridoxal phosphate biosynthetic process
G	0046982	molecular_function	protein heterodimerization activity
H	0042819	biological_process	vitamin B6 biosynthetic process
H	0042823	biological_process	pyridoxal phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue SO4 A 401

Chain	Residue
A	PHE135
D	LYS203
A	GLU154
A	ARG157
A	ARG158
B	HIS131
B	ARG153
B	ARG154
C	LYS208
C	HOH506

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 C 401

Chain	Residue
C	PHE135
C	GLU154
C	ARG157
C	ARG158
C	HOH518
D	HIS131
D	ARG153
D	ARG154

site_id	AC3
Number of Residues	11
Details	binding site for residue SO4 E 401

Chain	Residue
E	PHE135
E	GLU154
E	ARG157
E	ARG158
E	HOH526
E	HOH539
F	GLU150
F	ARG153
F	ARG154
G	LYS208
H	LYS203

site_id	AC4
Number of Residues	10
Details	binding site for residue SO4 B 301

Chain	Residue
A	GLY235
A	GLY256
B	PRO65
B	LYS165
B	ALA168
B	GLY169
B	GLY230
B	GLY251
B	HOH408
B	HOH410

site_id	AC5
Number of Residues	10
Details	binding site for residue SO4 D 301

Chain	Residue
C	GLY234
C	GLY235
C	GLY256
D	LYS165
D	GLU167
D	ALA168
D	GLY169
D	GLY229
D	GLY230
D	GLY251

site_id	AC6
Number of Residues	10
Details	binding site for residue SO4 F 301

Chain	Residue
E	GLY235
E	GLY256
E	HOH514
F	LYS165
F	ALA168
F	GLY169
F	GLY229
F	GLY230
F	GLY251
F	HOH402

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 H 301

Chain	Residue
G	PHE135
G	ARG157
G	ARG158
H	HIS131
H	GLU150
H	ARG153
H	ARG154

site_id	AC8
Number of Residues	7
Details	binding site for residue SO4 H 302

Chain	Residue
G	GLY235
G	GLY256
H	LYS165
H	GLY169
H	GLY230
H	GLY251
H	HOH405

site_id	AC9
Number of Residues	19
Details	binding site for Di-peptide LEU F 287 and LEU E 292

Chain	Residue
E	HIS283
E	VAL284
E	LEU285
E	ALA286
E	MET288
E	SER289
E	SER290
E	GLY291
E	GLU293
F	GLU278
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	GLY288

site_id	AD1
Number of Residues	19
Details	binding site for Di-peptide LEU F 287 and LEU E 292

Chain	Residue
E	GLY291
E	GLU293
F	GLU278
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	GLY288
E	HIS283
E	VAL284
E	LEU285
E	ALA286
E	MET288
E	SER289
E	SER290

site_id	AD2
Number of Residues	19
Details	binding site for Di-peptide LEU F 287 and LEU E 292

Chain	Residue
E	HIS283
E	VAL284
E	LEU285
E	ALA286
E	MET288
E	SER289
E	SER290
E	GLY291
E	GLU293
F	GLU278
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	GLY288

site_id	AD3
Number of Residues	19
Details	binding site for Di-peptide LEU F 287 and LEU E 292

Chain	Residue
E	HIS283
E	VAL284
E	LEU285
E	ALA286
E	MET288
E	SER289
E	SER290
E	GLY291
E	GLU293
F	GLU278
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	GLY288

site_id	AD4
Number of Residues	19
Details	binding site for Di-peptide LEU F 287 and LEU E 292

Chain	Residue
E	HIS283
E	VAL284
E	LEU285
E	ALA286
E	MET288
E	SER289
E	SER290
E	GLY291
E	GLU293
F	GLU278
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	GLY288

site_id	AD5
Number of Residues	19
Details	binding site for Di-peptide LEU F 287 and LEU E 292

Chain	Residue
E	HIS283
E	VAL284
E	LEU285
E	ALA286
E	MET288
E	SER289
E	SER290
E	GLY291
E	GLU293
F	GLU278
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	GLY288

site_id	AD6
Number of Residues	19
Details	binding site for Di-peptide LEU F 287 and LEU E 292

Chain	Residue
E	HIS283
E	VAL284
E	LEU285
E	ALA286
E	MET288
E	SER289
E	SER290
E	GLY291
E	GLU293
F	GLU278
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	GLY288

site_id	AD7
Number of Residues	19
Details	binding site for Di-peptide LEU F 287 and LEU E 292

Chain	Residue
E	HIS283
E	VAL284
E	LEU285
E	ALA286
E	MET288
E	SER289
E	SER290
E	GLY291
E	GLU293
F	GLU278
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	GLY288

site_id	AD8
Number of Residues	25
Details	binding site for Di-peptide GLY F 288 and GLU E 293

Chain	Residue
E	SER271
E	GLN274
E	VAL284
E	LEU285
E	ALA286
E	GLU287
E	SER289
E	SER290
E	GLY291
E	LEU292
E	ASN294
E	ALA295
F	ALA266
F	GLN269
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	LEU287
F	GLU289
F	ALA290

site_id	AD9
Number of Residues	25
Details	binding site for Di-peptide GLY F 288 and GLU E 293

Chain	Residue
E	SER271
E	GLN274
E	VAL284
E	LEU285
E	ALA286
E	GLU287
E	SER289
E	SER290
E	GLY291
E	LEU292
E	ASN294
E	ALA295
F	ALA266
F	GLN269
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	LEU287
F	GLU289
F	ALA290

site_id	AE1
Number of Residues	25
Details	binding site for Di-peptide GLY F 288 and GLU E 293

Chain	Residue
E	SER271
E	GLN274
E	VAL284
E	LEU285
E	ALA286
E	GLU287
E	SER289
E	SER290
E	GLY291
E	LEU292
E	ASN294
E	ALA295
F	ALA266
F	GLN269
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	LEU287
F	GLU289
F	ALA290

site_id	AE2
Number of Residues	25
Details	binding site for Di-peptide GLY F 288 and GLU E 293

Chain	Residue
E	SER271
E	GLN274
E	VAL284
E	LEU285
E	ALA286
E	GLU287
E	SER289
E	SER290
E	GLY291
E	LEU292
E	ASN294
E	ALA295
F	ALA266
F	GLN269
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	LEU287
F	GLU289
F	ALA290

site_id	AE3
Number of Residues	25
Details	binding site for Di-peptide GLY F 288 and GLU E 293

Chain	Residue
E	SER271
E	GLN274
E	VAL284
E	LEU285
E	ALA286
E	GLU287
E	SER289
E	SER290
E	GLY291
E	LEU292
E	ASN294
E	ALA295
F	ALA266
F	GLN269
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	LEU287
F	GLU289
F	ALA290

site_id	AE4
Number of Residues	25
Details	binding site for Di-peptide GLY F 288 and GLU E 293

Chain	Residue
E	SER271
E	GLN274
E	VAL284
E	LEU285
E	ALA286
E	GLU287
E	SER289
E	SER290
E	GLY291
E	LEU292
E	ASN294
E	ALA295
F	ALA266
F	GLN269
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	LEU287
F	GLU289
F	ALA290

site_id	AE5
Number of Residues	25
Details	binding site for Di-peptide GLY F 288 and GLU E 293

Chain	Residue
E	SER271
E	GLN274
E	VAL284
E	LEU285
E	ALA286
E	GLU287
E	SER289
E	SER290
E	GLY291
E	LEU292
E	ASN294
E	ALA295
F	ALA266
F	GLN269
F	MET279
F	LEU280
F	VAL281
F	GLU282
F	VAL283
F	SER284
F	CYS285
F	GLY286
F	LEU287
F	GLU289
F	ALA290

Functional Information from PROSITE/UniProt

site_id	PS01235
Number of Residues	19
Details	PDXS_SNZ_1 PdxS/SNZ family signature. VPVVQFASGGITTPADAAL

Chain	Residue	Details
A	VAL226-LEU244
B	LEU221-LEU239

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with D-ribose 5-phosphate => ECO:0000250\|UniProtKB:O59080

Chain	Residue	Details
B	LYS97
D	LYS97
F	LYS97
H	LYS97

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:O59080

Chain	Residue	Details
B	ASP40
F	GLY169
F	GLY230
F	GLY251
H	ASP40
H	GLY169
H	GLY230
H	GLY251
B	GLY169
B	GLY230
B	GLY251
D	ASP40
D	GLY169
D	GLY230
D	GLY251
F	ASP40

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q03148

Chain	Residue	Details
B	ARG181
D	ARG181
F	ARG181
H	ARG181

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)