6HXF
Human STK10 bound to a maleimide inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004674 | molecular_function | protein serine/threonine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004674 | molecular_function | protein serine/threonine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue R70 B 401 |
| Chain | Residue |
| B | LEU42 |
| B | GLY161 |
| B | ASN162 |
| B | LEU164 |
| B | ALA174 |
| B | EDO402 |
| B | HOH587 |
| B | HOH627 |
| B | GLY43 |
| B | PHE47 |
| B | VAL50 |
| B | ALA63 |
| B | ILE110 |
| B | GLU111 |
| B | PHE112 |
| B | CYS113 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| B | ASP119 |
| B | GLY161 |
| B | R70401 |
| B | HOH527 |
| B | HOH619 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 403 |
| Chain | Residue |
| B | ASP157 |
| B | LYS159 |
| B | ILE193 |
| B | THR195 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 404 |
| Chain | Residue |
| B | HIS149 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | TYR92 |
| B | GLN140 |
| B | GLU143 |
| B | HOH571 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue R70 A 401 |
| Chain | Residue |
| A | LEU42 |
| A | GLY43 |
| A | ASP44 |
| A | ALA63 |
| A | ILE110 |
| A | GLU111 |
| A | PHE112 |
| A | CYS113 |
| A | GLY161 |
| A | LEU164 |
| A | ALA174 |
| A | HOH579 |
| A | HOH594 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | HIS149 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | binding site for residue R70 C 401 |
| Chain | Residue |
| C | LEU42 |
| C | GLY43 |
| C | ASP44 |
| C | VAL50 |
| C | ALA63 |
| C | ILE110 |
| C | GLU111 |
| C | PHE112 |
| C | CYS113 |
| C | GLY161 |
| C | LEU164 |
| C | ALA174 |
| C | ASP175 |
| C | EDO402 |
| C | HOH580 |
| C | HOH588 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 402 |
| Chain | Residue |
| C | ASP119 |
| C | GLY161 |
| C | R70401 |
| C | HOH525 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for residue R70 D 401 |
| Chain | Residue |
| D | LEU42 |
| D | GLY43 |
| D | ASP44 |
| D | ALA63 |
| D | ILE110 |
| D | GLU111 |
| D | PHE112 |
| D | CYS113 |
| D | GLY161 |
| D | LEU164 |
| D | ALA174 |
| D | ASP175 |
| D | EDO404 |
| D | HOH572 |
| D | HOH574 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 402 |
| Chain | Residue |
| D | ASP157 |
| D | LYS159 |
| D | ILE193 |
| D | THR195 |
| D | EDO403 |
| D | HOH596 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 403 |
| Chain | Residue |
| D | ARG156 |
| D | PHE192 |
| D | MET199 |
| D | EDO402 |
| D | HOH505 |
| D | HOH539 |
| D | HOH585 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 404 |
| Chain | Residue |
| D | ASP119 |
| D | GLY161 |
| D | R70401 |
| D | HOH588 |
| D | HOH613 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGDGAFGKVYkAknketgal..........AAAK |
| Chain | Residue | Details |
| B | LEU42-LYS65 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKagNVLM |
| Chain | Residue | Details |
| B | ILE153-MET165 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
